About: Inhaled Nitric Oxide Therapy Fails to Improve Outcome in Experimental Severe Influenza

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhaled Nitric Oxide Therapy Fails to Improve Outcome in Experimental Severe Influenza
Creator	Miller, Chris Darwish, Ilyse Kain, Kevin Liles, W
Source	Medline; PMC
abstract	In vitro, nitric oxide (NO) has been shown to have antimicrobial activity against a wide range of viruses, including influenza A virus. Therefore, we hypothesized that inhaled nitric oxide (iNO) would increase survival in vivo by reducing the viral load in C57Bl/6 mice infected with a lethal dose of influenza A/WSN/33 (H1N1; WSN/33) virus. NO was delivered to influenza-infected mice either continuously or intermittently at 80 or 160 ppm, respectively, using both prophylactic and post-infection treatment strategies. Murine survival and weight loss were assessed, and lung viral load was quantified via plaque assay. Here, we report that iNO administered prophylactically or post-influenza infection failed to improve survival of infected mice. No difference in lung viral load was observed between experimental groups. Although NO has antiviral activity against influenza A virus in vitro, iNO therapy provided no apparent benefit when used for treatment of influenza A virus infection in vivo.
has issue date	2012-01-13(xsd:dateTime)
bibo:doi	10.7150/ijms.3880
bibo:pmid	22253563
has license	cc-by-nc-nd
sha1sum (hex)	d383ffc5115974fdaa97c744e2a579960a6c7cb2
schema:url	https://doi.org/10.7150/ijms.3880
resource representing a document's title	Inhaled Nitric Oxide Therapy Fails to Improve Outcome in Experimental Severe Influenza
has PubMed Central identifier	PMC3258558
has PubMed identifier	22253563
schema:publication	Int J Med Sci
resource representing a document's body	covid:d383ffc5115974fdaa97c744e2a579960a6c7cb2#body_text
is schema:about of	named entity 'USING' named entity 'LETHAL DOSE' named entity 'TREATMENT' named entity '160' named entity 'MICE' named entity 'INFLUENZA INFECTION' named entity 'THERAPY' named entity 'HERE' named entity 'REDUCING' named entity 'NITRIC OXIDE' named entity 'INFECTED' named entity 'ANTIMICROBIAL ACTIVITY' named entity 'EITHER' named entity 'INCLUDING' named entity 'PLAQUE ASSAY' named entity 'influenza A' named entity 'activity' named entity 'Here' named entity 'WSN' named entity 'delivered' named entity 'Nitric Oxide' named entity 'Influenza' named entity 'INHALED NITRIC OXIDE' named entity 'THERAPY' named entity 'IN VIVO' named entity 'GROUPS' named entity 'STRATEGIES' named entity 'FAILS' named entity 'EXPERIMENTAL' named entity 'PROPHYLACTIC' named entity 'INO' named entity 'VIRUS' named entity 'SEVERE' named entity 'USED' named entity 'VIRUSES' named entity 'INFLUENZA A VIRUS' named entity 'INCREASE' named entity 'VIRAL LOAD' named entity 'ASSESSED' named entity 'C57BL' named entity 'WSN' named entity 'BENEFIT' named entity 'LUNG' named entity 'FAILED' named entity 'REPORT' named entity 'PPM' named entity 'INHALED NITRIC OXIDE' named entity 'HAVE' named entity 'INFLUENZA' named entity 'DELIVERED' named entity 'WIDE' named entity 'MURINE' named entity 'WEIGHT LOSS' named entity 'EXPERIMENTAL' named entity 'APPARENT' named entity 'NO DIFFERENCE' named entity 'ADMINISTERED' named entity 'INFLUENZA' named entity 'OUTCOME' named entity 'SURVIVAL' named entity 'POST' named entity 'PROVIDED' named entity 'RANGE' named entity 'INFECTION' named entity 'INFLUENZA A VIRUS INFECTION' named entity 'IN VITRO' named entity 'INFLUENZA A' named entity 'ANTIVIRAL ACTIVITY' named entity 'OBSERVED' covid:arg/d383ffc5115974fdaa97c744e2a579960a6c7cb2 named entity 'prophylactic' named entity 'nitric oxide' named entity 'wide range' named entity 'In vitro' named entity 'influenza A virus' named entity 'activity' named entity 'viral load' named entity 'failed'

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