About: Emerging complexity and new roles for the RIG-I-like receptors in innate antiviral immunity

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About: Emerging complexity and new roles for the RIG-I-like receptors in innate antiviral immunity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Emerging complexity and new roles for the RIG-I-like receptors in innate antiviral immunity
Creator	Cas, Springer-Verlag, Wiv, ©
Source	Medline; PMC
abstract	Innate immunity is critical for the control of virus infection and operates to restrict viral susceptibility and direct antiviral immunity for protection from acute or chronic viral-associated diseases including cancer. RIG-I like receptors (RLRs) are cytosolic RNA helicases that function as pathogen recognition receptors to detect RNA pathogen associated molecular patterns (PAMPs) of virus infection. The RLRs include RIG-I, MDA5, and LGP2. They function to recognize and bind to PAMP motifs within viral RNA in a process that directs the RLR to trigger downstream signaling cascades that induce innate immunity that controls viral replication and spread. Products of RLR signaling also serve to modulate the adaptive immune response to infection. Recent studies have additionally connected RLRs to signaling cascades that impart inflammatory and apoptotic responses to virus infection. Viral evasion of RLR signaling supports viral outgrowth and pathogenesis, including the onset of viral-associated cancer.
has issue date	2015-05-19(xsd:dateTime)
bibo:doi	10.1007/s12250-015-3604-5
bibo:pmid	25997992
has license	no-cc
sha1sum (hex)	d38449e1a1e5fb36468240e81086d45019e5af9a
schema:url	https://doi.org/10.1007/s12250-015-3604-5
resource representing a document's title	Emerging complexity and new roles for the RIG-I-like receptors in innate antiviral immunity
has PubMed Central identifier	PMC7090589
has PubMed identifier	25997992
schema:publication	Virol Sin
resource representing a document's body	covid:d38449e1a1e5fb36468240e81086d45019e5af9a#body_text
is schema:about of	named entity 'signaling' named entity 'Innate immunity' named entity 'infection' named entity 'onset' named entity 'acute' named entity 'PAMPs' named entity 'responses' named entity 'PRODUCTS' named entity 'INCLUDE' named entity 'ACUTE' named entity 'PATTERNS' named entity 'RECEPTORS' named entity 'RNA HELICASES' named entity 'RIG-I' named entity 'RESPONSES' named entity 'HAVE' named entity 'RECOGNIZE' named entity 'LGP2' named entity 'PAMP' named entity 'RESPONSE TO' named entity 'CYTOSOLIC' named entity 'PATHOGENESIS' named entity 'RECENT' named entity 'serve' named entity 'RIG-I' named entity 'virus' named entity 'LGP2' named entity 'function' named entity 'pathogen' named entity 'cancer' named entity 'RIG-I' named entity 'signaling cascades' named entity 'directs' named entity 'RNA' named entity 'signaling cascades' named entity 'viral RNA' named entity 'RLR' named entity 'apoptotic' named entity 'PAMP' named entity 'viral replication' named entity 'RIG-I' named entity 'innate antiviral immunity' named entity 'direct' named entity 'cancer' named entity 'transfection' named entity 'infection' named entity 'virus' named entity 'adaptive response' named entity 'MDA5' named entity 'cytosolic' named entity 'RLR' named entity 'WNV' named entity 'virus infection' named entity 'ligands' named entity 'infection' named entity 'RNAs' named entity 'chemokines' named entity 'NS3' named entity 'MDA5' named entity 'MAVS' named entity 'MAVS' named entity 'cofactors' named entity 'RIG-I' named entity 'uridine' named entity 'RLR' named entity 'RLR' named entity 'ligand' named entity 'antiviral' named entity 'innate immunity' named entity 'NF-κB' named entity 'MDA5' named entity 'PAMPs' named entity 'etiology' named entity 'phenotype' named entity 'Paramyxoviridae' named entity 'PRRs' named entity 'positive sense RNA viruses' named entity 'LGP2' named entity 'cell types'

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