About: Mixing ratio optimization for functional complex extracts of Rhodiola crenulata, Panax quinquefolius, and Astragalus membranaceus using mixture design and verification of immune functional efficacy in animal models

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About: Mixing ratio optimization for functional complex extracts of Rhodiola crenulata, Panax quinquefolius, and Astragalus membranaceus using mixture design and verification of immune functional efficacy in animal models Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mixing ratio optimization for functional complex extracts of Rhodiola crenulata, Panax quinquefolius, and Astragalus membranaceus using mixture design and verification of immune functional efficacy in animal models
Creator	Cho, Chang-Won Hong, Hee-Do Jang, Mi Kim, Jong-Chan Lim, Tae-Gyu Song, Young-Ran
Source	Elsevier; Medline; PMC
abstract	We aimed to identify the optimum mixing ratio for various ingredients to obtain complex extracts with high extract yields and immune-enhancing activity in animals. The extract yield and amounts of nitric oxide (NO) and interleukin (IL)-6 were set to maximum for modeling predictions. The predicted optimum values for the mixing ratio were 49.5% for Rhodiola crenulata, 26.1% for Astragalus membranaceus, and 24.4% for Panax quinquefolius, and the predicted response values were 31.5% yield, 13.4% NO production, and 6.1% IL-6 production; actual values were 35.3% yield, 14.7% NO, and 6.6% IL-6. The optimum mixing ratio extract (OMRE) was used for the animal experiments. Treating mice with OMRE at 200 mg/kg produced significant increases in spleen indexes and T-cell/B-cell proliferation. OMRE treatment increased IL-10 and IL-6 production in concanavalin A- and lipopolysaccharide-induced T- and B- lymphocytes, respectively. These results provide a basis for the development of functional extracts and drinks.
has issue date	2017-11-28(xsd:dateTime)
bibo:doi	10.1016/j.jff.2017.11.038
bibo:pmid	32288793
has license	no-cc
sha1sum (hex)	d3bc2c45d22aa665acaf4e35abb2bb48b2ae4b6b
schema:url	https://doi.org/10.1016/j.jff.2017.11.038
resource representing a document's title	Mixing ratio optimization for functional complex extracts of Rhodiola crenulata, Panax quinquefolius, and Astragalus membranaceus using mixture design and verification of immune functional efficacy in animal models
has PubMed Central identifier	PMC7105012
has PubMed identifier	32288793
schema:publication	J Funct Foods
resource representing a document's body	covid:d3bc2c45d22aa665acaf4e35abb2bb48b2ae4b6b#body_text
is schema:about of	named entity 'EFFICACY' named entity 'USING' named entity 'THESE' named entity 'PREDICTIONS' named entity 'INDUCED' named entity 'VARIOUS' named entity 'FUNCTIONAL' named entity 'ANIMAL MODELS' named entity 'HIGH' named entity 'COMPLEX' named entity 'NO PRODUCTION' named entity 'MODELING' named entity 'INCREASED' named entity 'MG%' named entity '2FB' named entity 'IL-10' named entity 'INTERLEUKIN ' named entity 'OBTAIN' named entity '6.6' named entity 'DRINKS' named entity 'DEVELOPMENT' named entity 'IL-6' named entity 'ANIMALS' named entity 'EXTRACT' named entity 'MIXING RATIO' named entity 'IMMUNE' named entity 'RESULTS' named entity 'MAXIMUM' named entity 'DESIGN' named entity 'VERIFICATION' named entity 'OPTIMIZATION' named entity 'ASTRAGALUS MEMBRANACEUS' named entity 'COMPLEX' named entity 'ENHANCING' named entity 'IMMUNE' named entity 'EXTRACTS' named entity 'MIXING RATIO' named entity 'RHODIOLA CRENULATA' named entity 'NITRIC OXIDE' named entity 'ACTUAL' named entity 'ASTRAGALUS MEMBRANACEUS' named entity 'TREATING' named entity 'MIXTURE' named entity 'SPLEEN' named entity 'YIELD' named entity 'PANAX QUINQUEFOLIUS' named entity 'RHODIOLA CRENULATA' named entity '13.4' named entity 'LIPOPOLYSACCHARIDE' named entity 'CONCANAVALIN A' named entity 'TREATMENT' named entity 'AMOUNTS' named entity 'B-LYMPHOCYTES' named entity 'T-CELL' named entity 'FUNCTIONAL' named entity 'RESPONSE' named entity 'ANIMAL EXPERIMENTS' named entity 'SET' named entity 'PROVIDE' named entity 'CELL PROLIFERATION' named entity 'PREDICTED' named entity 'EXTRACTS' named entity 'PANAX QUINQUEFOLIUS' named entity 'SIGNIFICANT' named entity 'BASIS' named entity 'USED' named entity 'VALUES' named entity 'OPTIMUM' named entity 'IL-6 PRODUCTION' named entity 'ACTIVITY' named entity 'INCREASES' named entity '200' named entity 'TO IDENTIFY' named entity 'INDEXES' named entity 'MICE' covid:arg/d3bc2c45d22aa665acaf4e35abb2bb48b2ae4b6b

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