About: Direct molecular detection of a broad range of bacterial and viral organisms and Streptococcus pneumoniae vaccine serotypes in children with otitis media with effusion

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About: Direct molecular detection of a broad range of bacterial and viral organisms and Streptococcus pneumoniae vaccine serotypes in children with otitis media with effusion Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Direct molecular detection of a broad range of bacterial and viral organisms and Streptococcus pneumoniae vaccine serotypes in children with otitis media with effusion
Creator	Chan, Francis Slinger, Robert Bromwich, Matthew Duval, Melanie Langill, Jonathan Vaccani, Jean-Philippe Maccormick, Johnna
Source	Medline; PMC
abstract	BACKGROUND: Otitis media with effusion (OME) causes significant morbidity in children, but the causes of OME and methods for prevention are unclear. To look for potential infectious etiologies, we performed a pilot study using multiple-target real-time polymerase chain reaction (qPCR) for 27 infectious agents, including nine bacterial organisms and 18 respiratory viruses in middle ear fluids (MEFs) from children with OME. QPCR was also performed for the 13 Streptococcus pneumoniae serotypes contained in the current vaccine. RESULTS: Forty-eight MEF samples were obtained and qPCR detected bacterial nucleic acid (NA) in 39/48 (81 %) and viral NA in 7/48 (15 %). Alloiococcus otitidis and S. pneumoniae were both detected in 15/48 (31 %) MEFs, followed by M. catarrhalis in 14/48 (29 %), H. influenzae in 5/48 (10 %) and M. pneumoniae in 4/48 (8 %). Rhinoviruses were most common virus type detected, found in 4/48 (8 %) MEFs. Serotypes included in the current 13-serotype vaccine were detected in only 3/15 (20 %) S. pneumoniae qPCR-positive MEFs. CONCLUSIONS: Bacteria may play an important role in OME, since over 80 % of MEFs contained bacterial NA. Further research into the role of A. otitidis in OME will be helpful. Serotypes of S. pneumoniae not included in the current 13-serotype vaccine may be involved in OME. Larger studies of OME S. pneumoniae serotypes are needed to help determine which additional serotypes should be included in future vaccine formulations in order to try to prevent OME.
has issue date	2016-04-29(xsd:dateTime)
bibo:doi	10.1186/s13104-016-2040-4
bibo:pmid	27130295
has license	cc-by
sha1sum (hex)	d3ca5f2f620d495c747bac2a00b3446b392f7535
schema:url	https://doi.org/10.1186/s13104-016-2040-4
resource representing a document's title	Direct molecular detection of a broad range of bacterial and viral organisms and Streptococcus pneumoniae vaccine serotypes in children with otitis media with effusion
has PubMed Central identifier	PMC4850712
has PubMed identifier	27130295
schema:publication	BMC Res Notes
resource representing a document's body	covid:d3ca5f2f620d495c747bac2a00b3446b392f7535#body_text
is schema:about of	named entity 'SEROTYPES' named entity 'DIRECT' named entity 'pilot study' named entity 'RANGE' named entity 'PREVENTION' named entity 'QPCR' named entity 'MULTIPLE' named entity 'INFECTIOUS' named entity 'CHILDREN' named entity 'SEROTYPES' named entity 'SIGNIFICANT' named entity 'PILOT STUDY ' named entity 'BACTERIAL' named entity 'USING' named entity 'CONTAINED IN' named entity 'BACKGROUND' named entity 'OTITIS MEDIA WITH EFFUSION' named entity 'DETECTION' named entity 'INCLUDING' named entity 'RESPIRATORY VIRUSES' named entity 'ORGANISMS' named entity 'MORBIDITY' covid:arg/d3ca5f2f620d495c747bac2a00b3446b392f7535 named entity 'INFECTIOUS AGENTS' named entity 'FLUIDS' named entity 'UNCLEAR' named entity 'CHILDREN' named entity 'MOLECULAR' named entity 'BROAD' named entity 'OTITIS MEDIA WITH EFFUSION' named entity 'BACTERIAL' named entity 'VIRAL' named entity 'ORGANISMS' named entity 'METHODS' named entity 'MIDDLE EAR' named entity 'CURRENT' named entity 'PERFORMED' named entity 'CAUSES' named entity 'STREPTOCOCCUS PNEUMONIAE VACCINE' named entity 'POTENTIAL' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'VACCINE' named entity 'REAL-TIME POLYMERASE CHAIN REACTION' named entity 'TARGET' named entity 'BUT' named entity 'LOOK' named entity 'polymerase' named entity 'bacterial' named entity 'organisms' named entity 'viral' named entity 'morbidity' named entity 'etiologies' named entity 'infectious agents' named entity 'qPCR' named entity 'Streptococcus pneumoniae vaccine' named entity 'otitis media with effusion' named entity 'Studies examining' named entity 'pathogenicity' named entity 'vaccine' named entity 'pathogenicity' named entity 'hearing loss' named entity 'planktonic' named entity 'middle ear' named entity 'H. influenzae' named entity 'live bacteria' named entity 'fluorescein' named entity 'organism' named entity 'anaerobic bacteria' named entity 'culture-based' named entity 'Coralville' named entity 'bacterial culture' named entity 'bacteria' named entity 'virus' named entity 'MGB' named entity 'unable to perform'

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