About: Olfactory and Gustatory Dysfunction as An Early Identifier of COVID-19 in Adults and Children: An International Multicenter Study

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About: Olfactory and Gustatory Dysfunction as An Early Identifier of COVID-19 in Adults and Children: An International Multicenter Study Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Olfactory and Gustatory Dysfunction as An Early Identifier of COVID-19 in Adults and Children: An International Multicenter Study
Creator	Chen, Bing Lu, Hongzhou Zhao, Qi Liu, Li Zhao, Jun Herman, Philippe Zeng, Mei Zhang, Di Zeng, Hui Shu, Yilai Dai, Qi Liu, Zhao, ; Antje, ; Casiano, ; Casiano, Roy Cejas, Ivette Cejas, Qi Chen, Dushyantha Clement Jourdaine, ; Cui, Chong Dai, Katja De With, Julia Denneny, C Draf, Bing Draf, Julia Eshraghi, Adrien Haehner, Antje Haehner, Jun Hautefort, Charlotte Hummel, Thomas James, ; Jayaweera, Dushyantha Jayaweera, James Katja De With, ; Levine, Corinna Liu, Xuezhong Nisenbaum, Li Qiu, Chenghao Yao, Yao, Qi Yu, Hongmeng Zen, Hui
source	MedRxiv; Medline
abstract	Abstract Objective: Evaluate the prevalence and characteristics of olfactory or gustatory dysfunction in COVID-19 patients Study Design: Multicenter Case Series Setting: 5 tertiary care hospitals (3 in China, 1 in France, 1 in Germany) Subjects and Methods: 394 PCR confirmed COVID-19 positive patients were screened, and those with olfactory or gustatory dysfunction were included. Data including demographics, COVID-19 severity, patient outcome, and the incidence and degree of olfactory and/or gustatory dysfunction were collected and analyzed. The Questionnaire of Olfactory Disorders (QOD) and Visual Analogue Scale (VAS) were used to quantify olfactory and gustatory dysfunction respectively. All subjects at one hospital (Shanghai) without subjective olfactory complaints underwent objective testing. Results: Of 394 screened subjects, 161 (41%) reported olfactory and/or gustatory dysfunction and were included. Incidence of olfactory and/or gustatory disorders in Chinese (n=239), German (n=39) and French (n=116) cohorts were 32%, 69%, and 49% 138 respectively. The median age of included subjects was 39 years old, 92/161 (57%) were male, and 10/161 (6%) were children. Of included subjects, 10% had only olfactory or gustatory symptoms, and 19% had olfactory and/or gustatory complaints prior to any other COVID-19 symptom. Of subjects with objective olfactory testing, 10/90 demonstrated abnormal chemosensory function despite reporting normal subjective olfaction. 43% (44/102) of subjects with follow-up showed symptomatic improvement in olfaction or gustation. Conclusions: Olfactory and/or gustatory disorders may represent early or isolated symptoms of SARS-CoV-2 infection. They may serve as a useful additional screening criterion, particularly for the identification of patients in the early stages of infection.
has issue date	2020-05-16(xsd:dateTime)
bibo:doi	10.1101/2020.05.13.20100198
bibo:pmid	32511546
has license	medrxiv
sha1sum (hex)	d3e7ec04c24315ed1f14b9bddd84ac091a8a22a8
schema:url	https://doi.org/10.1101/2020.05.13.20100198
resource representing a document's title	Olfactory and Gustatory Dysfunction as An Early Identifier of COVID-19 in Adults and Children: An International Multicenter Study
has PubMed identifier	32511546
schema:publication	medRxiv : the preprint server for health sciences
resource representing a document's body	covid:d3e7ec04c24315ed1f14b9bddd84ac091a8a22a8#body_text
is schema:about of	named entity 'Setting' named entity 'PCR' named entity 'Objective' named entity 'CHINA' named entity '103' named entity 'PREVALENCE' named entity 'INTEGRITY OF' named entity 'data' named entity 'Study' named entity 'tertiary care hospitals' named entity 'PCR' named entity 'China' named entity 'Case Series' named entity 'COVID-19' named entity 'rhinorrhea' named entity 'olfactory' named entity 'gustation' named entity 'medRxiv' named entity 'gustatory' named entity 'COVID' named entity 'organ' named entity 'peer review' named entity 'symptom' named entity 'China' named entity 'olfactory' named entity 'infection' named entity 'hearing loss' named entity 'peer review' named entity 'East Asia' named entity 'olfactory function' named entity 'olfactory' named entity 'ACE2' named entity 'Asymptomatic patients' named entity 'QOD' named entity 'fatigue' named entity 'low fever' named entity 'Olfactory' named entity 'May 16' named entity 'olfactory' named entity 'anosmia'

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