About: Up-regulation of carcinoembryonic antigen-related cell adhesion molecule 1 in gastrointestinal cancer and its clinical relevance

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About: Up-regulation of carcinoembryonic antigen-related cell adhesion molecule 1 in gastrointestinal cancer and its clinical relevance Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Up-regulation of carcinoembryonic antigen-related cell adhesion molecule 1 in gastrointestinal cancer and its clinical relevance
Creator	Gao, Feng Du, Yan Cao, Manlin Cui, Lian He, Yiqing Hu, Jiajie Jin, Zhiming Liu, Yiwen Wang, Yingzhi Yang, Cuixia Zhou, Muqing
Source	PMC
abstract	Serum carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is dysregulated in various malignant tumors and has been associated with tumor progression. However, the expression and regulatory mechanisms of serum CEACAM1 in gastrointestinal cancer are still unclear. The expression ratio of the CEACAM1-L and CEACAM1-S isoforms has seldom been investigated in gastrointestinal cancer. In this study, we intended to explore the expression and diagnostic value of CEACAM1 in gastrointestinal cancer. Serum CEACAM1 levels were measured by enzyme-linked immunosorbent assay. The protein expression and distribution of CEACAM1 in tumors were examined by immunohistochemical staining. The expression patterns and ratio of CEACAM1-L/S were analyzed by reverse transcription-polymerase chain reaction. The results showed that serum CEACAM1 levels were significantly higher in cancer patients than in healthy controls. CEACAM1 was found in secreted forms within the neoplastic glands, and its expression was more intense at the tumor invasion front. The CEACAM1-L/S (L:S) ratios were up-regulated during tumorigenesis. Our data suggest that the serum level of CEACAM1 may be used to discriminate gastrointestinal cancer patients from health controls.
has issue date	2017-06-24(xsd:dateTime)
bibo:doi	10.1093/abbs/gmx060
bibo:pmid	28655144
has license	no-cc
sha1sum (hex)	d3fd7a09ccd8419072c58707cc666c60e7207c5b
schema:url	https://doi.org/10.1093/abbs/gmx060
resource representing a document's title	Up-regulation of carcinoembryonic antigen-related cell adhesion molecule 1 in gastrointestinal cancer and its clinical relevance
has PubMed Central identifier	PMC7109844
has PubMed identifier	28655144
schema:publication	Acta Biochim Biophys Sin (Shanghai)
resource representing a document's body	covid:d3fd7a09ccd8419072c58707cc666c60e7207c5b#body_text
is schema:about of	named entity 'Our' named entity 'distribution' named entity 'gastrointestinal cancer' named entity 'intended' named entity 'However' named entity 'LEVELS' named entity 'STUDY' named entity 'USED' named entity 'SERUM CARCINOEMBRYONIC ANTIGEN' named entity 'PROTEIN EXPRESSION' named entity 'RATIO' named entity 'HEALTH' named entity 'CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1' named entity 'SERUM' named entity 'ITS' named entity 'WITH TUMOR' named entity 'TUMOR INVASION' named entity 'INTENSE' named entity 'FOUND' named entity 'RATIOS' named entity 'SECRETED' named entity 'OUR' named entity 'FORMS' named entity 'LEVEL' named entity 'NEOPLASTIC' named entity 'CANCER' named entity 'UP-REGULATION' named entity 'CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1' named entity 'MECHANISMS' named entity 'REGULATORY' named entity 'ITS' named entity 'GASTROINTESTINAL CANCER' named entity 'ASSAY' named entity 'TUMORIGENESIS' named entity 'VARIOUS' named entity 'SELDOM' named entity 'MAY BE' named entity 'SUGGEST' named entity 'REVERSE TRANSCRIPTION' named entity 'CLINICAL RELEVANCE' named entity 'EXAMINED' named entity 'EXPRESSION' named entity 'INTENDED' named entity 'ISOFORMS' named entity 'RESULTS' named entity 'PATTERNS' named entity 'IMMUNOHISTOCHEMICAL STAINING' named entity 'INVESTIGATED' named entity 'HIGHER' named entity 'GLANDS' named entity 'UNCLEAR' named entity 'ASSOCIATED WITH' named entity 'TUMORS' named entity 'POLYMERASE CHAIN REACTION' named entity 'GASTROINTESTINAL CANCER' named entity 'MEASURED' named entity 'DISCRIMINATE' named entity 'DISTRIBUTION' named entity 'VALUE' named entity 'DIAGNOSTIC' named entity 'UP-REGULATED' named entity 'PATIENTS' named entity 'IMMUNOSORBENT' named entity 'TUMOR PROGRESSION' named entity 'ANALYZED' named entity 'MALIGNANT TUMORS' named entity 'CEACAM1' named entity 'DATA' named entity 'HEALTHY' covid:arg/d3fd7a09ccd8419072c58707cc666c60e7207c5b named entity 'L/S'

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