About: Hepatitis C virus infection induces endoplasmic reticulum stress and apoptosis in human fetal liver stem cells

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About: Hepatitis C virus infection induces endoplasmic reticulum stress and apoptosis in human fetal liver stem cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hepatitis C virus infection induces endoplasmic reticulum stress and apoptosis in human fetal liver stem cells
Creator	Yang, Dong Jin, Min Li, Jun-Wen Liu, Wei-Li Shen, Zhi-Qiang Guo, Xuan Library, Wiley Qiu, Zhi-Gang
Source	Medline; PMC
abstract	The cellular mechanisms by which hepatitis C virus (HCV) replication might mediate cytopathic effects are controversial and not entirely clear. In this study, we found that blood‐borne HCV (bbHCV) infection could lead to endoplasmic reticulum (ER)‐stress and mitochondria‐related/caspase‐dependent apoptosis at the early stages of infection based on use of the highly efficient bbHCV cell culture model established previously. Sections of bbHCV‐infected human fetal liver stem cells (hFLSCs) revealed convolution and nonlinear ER, cell vacuolization, swelling of mitochondria, and numerous double membrane vesicles (DMVs). The percentage of apoptotic hFLSCs infected by bbHCV reached 29.8% at 16 h postinfection, and the amount of cytochrome c increased remarkably in the cytosolic protein fraction. However, over time, apoptosis was inhibited due to the activation of NF‐κB. The expression of NF‐κB‐p65, Bcl‐xL, XIAP, and c‐FLIPL in hFLSCs was increased significantly 24 h after in infection by bbHCV. The accelerated cell death cycles involving apoptosis, regeneration and repair by bbHCV infection might give rise to the development of cirrhosis, and ultimately to hepatocellular carcinogenesis. Copyright © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
has issue date	2019-02-20(xsd:dateTime)
bibo:doi	10.1002/path.5240
bibo:pmid	30680725
has license	no-cc
sha1sum (hex)	d400f217efaa55e7de90befa8580ef409ff5c2a5
schema:url	https://doi.org/10.1002/path.5240
resource representing a document's title	Hepatitis C virus infection induces endoplasmic reticulum stress and apoptosis in human fetal liver stem cells
has PubMed Central identifier	PMC7167977
has PubMed identifier	30680725
schema:publication	J Pathol
resource representing a document's body	covid:d400f217efaa55e7de90befa8580ef409ff5c2a5#body_text
is schema:about of	named entity 'replication' named entity 'EARLY STAGES' named entity 'EFFICIENT' covid:arg/d400f217efaa55e7de90befa8580ef409ff5c2a5 named entity 'infection' named entity 'stress' named entity 'human' named entity 'HCV' named entity 'infection' named entity 'endoplasmic reticulum' named entity 'endoplasmic reticulum stress' named entity 'caspase-dependent apoptosis' named entity 'S1C' named entity 'life cycle' named entity 'HCV' named entity 'infection' named entity 'human immunodeficiency virus 1' named entity 'Peking Union Medical College Hospital' named entity 'HCV' named entity 'serum' named entity 'propidium iodide' named entity 'virus replication' named entity 'standard curve' named entity 'mitochondrial' named entity 'flow cytometer' named entity 'apoptotic' named entity 'respiratory activity' named entity 'cell death' named entity 'viral hepatitis' named entity 'vacuolization' named entity 'health problem' named entity 'apoptotic effects' named entity 'antibodies' named entity 'Huh-7' named entity 'DMEM' named entity 'cell death' named entity 'toxoplasmosis' named entity '0.45' named entity 'nonstructural proteins' named entity 'hepatitis' named entity 'DAPI' named entity 'hepatocytes' named entity 'cytochrome oxidase' named entity 'hepatoma' named entity 'citrate' named entity 'subunit II' named entity 'lysis' named entity 'protein' named entity 'DMVs' named entity 'HCV' named entity 'metabolic' named entity 'annexin' named entity 'infection' named entity 'BSA' named entity 'apoptosis' named entity 'supernatant' named entity 'cirrhosis' named entity 'cytochrome' named entity 'vacuoles' named entity 'Chicago' named entity 'San Diego' named entity 'Cytochrome' named entity 'nmol' named entity 'horseradish peroxidase' named entity 'HCV' named entity '3, 4' named entity 'recombinant virus' named entity 'HCV' named entity 'PBS' named entity 'immunoblotting' named entity 'Electron Microscopy' named entity 'SDS-PAGE' named entity 'RT-qPCR' named entity 'flow cytometer'

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