About: New insights into the importance of aminopeptidase A in hypertension

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About: New insights into the importance of aminopeptidase A in hypertension Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	New insights into the importance of aminopeptidase A in hypertension
Creator	Wright, John Numaguchi, Y Wright, J Ae, Ishii Ae, Murohara Ae, Nomura Ae, Tsujimoto Hattori, A Hattori, Akira Ishii, Á Kobayshi, H Kobayshi, Hiroshi Masafumi, A Masakazu, A Mizutani, S Mizutani, Shigehiko Murohara, T Nomura, S Numaguchi, Yasushi Seiji, A Toyoaki, A Tsujimoto, Á
Source	PMC
abstract	The renin-angiotensin system (RAS) plays an important role in the maintenance of normal blood pressure and the etiology of hypertension; however, minimal attention has been paid to the degradation of the effector peptide, angiotensin II (AngII). Since aminopeptidase A (APA)-deficient mice develop hypertension APA appears to be an essential enzyme in the control of blood pressure via degradation of AngII. The robust hypertension seen in the spontaneously hypertensive rat (SHR) is due to activation of the RAS, and an accompanying decrease in kidney APA. Changes in APA have also been measured during the activation of the RAS in the Goldblatt hypertension model and Dahl salt-sensitive (DSS) rat. The DSS rat shows an elevation in renal APA activity at the onset of hypertension suggesting a protective role against elevations in circulating AngII, followed by decreased APA activity with advancing hypertension. Changes seen in human maternal serum APA activity during preeclampsia are similar to changes measured in renal APA in the DSS rat model. APA activity is higher than during normal pregnancy at the onset of preeclampsia, and with advancing preeclampsia (severe preeclampsia) declines below that seen during normal pregnancy. Serum APA activity is also increased during hormone replacement therapy (HRT), perhaps in reaction to elevated levels of AngII. Thus, it appears important to consider the relationship among activation of the RAS, circulating levels of AngII, and the availability of APA in hypertensive disorders.
has issue date	2007-11-08(xsd:dateTime)
bibo:doi	10.1007/s10741-007-9065-7
bibo:pmid	17990103
has license	no-cc
sha1sum (hex)	d415b068ab263711030a7e9f6db4bf637336a503
schema:url	https://doi.org/10.1007/s10741-007-9065-7
resource representing a document's title	New insights into the importance of aminopeptidase A in hypertension
has PubMed Central identifier	PMC7101674
has PubMed identifier	17990103
schema:publication	Heart Fail Rev
resource representing a document's body	covid:d415b068ab263711030a7e9f6db4bf637336a503#body_text
is schema:about of	named entity 'APA' named entity 'enzyme' named entity 'APA' named entity 'degradation' named entity 'control' named entity 'III' named entity 'receptor' named entity 'HAVE' named entity 'ATTENTION' named entity 'CONTROL OF BLOOD PRESSURE' named entity 'hypertension' named entity 'angiotensin' named entity 'renal' named entity 'levels' named entity 'activation' named entity 'hypertension' named entity 'hormone replacement therapy' named entity 'preeclampsia' named entity 'activity' named entity 'normal' named entity 'normal' named entity 'Circumventricular organs' named entity 'Angiotensin' named entity 'hypertension' named entity 'RAS' named entity 'RAS' named entity 'preeclampsia' named entity 'hypertension' named entity 'preeclampsia' named entity 'peptide' named entity 'aminopeptidase' named entity 'Aminopeptidase' named entity 'aminopeptidase' named entity 'Angiotensin IV' named entity 'Angiotensin' named entity 'Aminopeptidase' named entity 'APA' named entity 'vasopressin' named entity 'kidney' named entity 'ventral medulla' named entity 'APA' named entity 'APA' named entity 'OVLT' named entity 'renin' named entity 'renal function' named entity 'normotensive' named entity 'potency' named entity 'hyalinization' named entity 'placenta' named entity '7-transmembrane domain' named entity 'blood pressure' named entity 'animal models' named entity 'sclerotic' named entity 'arterial blood' named entity 'blood pressure' named entity 'renin-angiotensin' named entity 'etiology' named entity 'fetus' named entity 'APA' named entity 'renin'

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