About: Angiotensin-converting enzyme 2 (ACE2) proteins of different bat species confer variable susceptibility to SARS-CoV entry

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About: Angiotensin-converting enzyme 2 (ACE2) proteins of different bat species confer variable susceptibility to SARS-CoV entry Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Angiotensin-converting enzyme 2 (ACE2) proteins of different bat species confer variable susceptibility to SARS-CoV entry
Creator	Wang, Lin-Fa Shi, Zhengli Li, Yan Hou, Yuxuan Cheng, • Fang, Han Meng, Peng Zhenggang, •
Source	Medline; PMC
abstract	The discovery of SARS-like coronavirus in bats suggests that bats could be the natural reservoir of SARS-CoV. However, previous studies indicated the angiotensin-converting enzyme 2 (ACE2) protein, a known SARS-CoV receptor, from a horseshoe bat was unable to act as a functional receptor for SARS-CoV. Here, we extended our previous study to ACE2 molecules from seven additional bat species and tested their interactions with human SARS-CoV spike protein using both HIV-based pseudotype and live SARS-CoV infection assays. The results show that ACE2s of Myotis daubentoni and Rhinolophus sinicus support viral entry mediated by the SARS-CoV S protein, albeit with different efficiency in comparison to that of the human ACE2. Further, the alteration of several key residues either decreased or enhanced bat ACE2 receptor efficiency, as predicted from a structural modeling study of the different bat ACE2 molecules. These data suggest that M. daubentoni and R. sinicus are likely to be susceptible to SARS-CoV and may be candidates as the natural host of the SARS-CoV progenitor viruses. Furthermore, our current study also demonstrates that the genetic diversity of ACE2 among bats is greater than that observed among known SARS-CoV susceptible mammals, highlighting the possibility that there are many more uncharacterized bat species that can act as a reservoir of SARS-CoV or its progenitor viruses. This calls for continuation and expansion of field surveillance studies among different bat populations to eventually identify the true natural reservoir of SARS-CoV. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00705-010-0729-6) contains supplementary material, which is available to authorized users.
has issue date	2010-06-22(xsd:dateTime)
bibo:doi	10.1007/s00705-010-0729-6
bibo:pmid	20567988
has license	no-cc
sha1sum (hex)	d421fc2ed42637e8d28b820f9ca2f2a837d39751
schema:url	https://doi.org/10.1007/s00705-010-0729-6
resource representing a document's title	Angiotensin-converting enzyme 2 (ACE2) proteins of different bat species confer variable susceptibility to SARS-CoV entry
has PubMed Central identifier	PMC7086629
has PubMed identifier	20567988
schema:publication	Arch Virol
resource representing a document's body	covid:d421fc2ed42637e8d28b820f9ca2f2a837d39751#body_text
is schema:about of	named entity 'SARS-CoV' named entity 'SARS-CoV' named entity 'horseshoe bat' named entity 'viral entry' named entity 'assays' named entity 'ACE2' named entity 'SUSCEPTIBILITY' named entity 'LIKELY' named entity 'HORSESHOE BAT' named entity 'PROTEIN' named entity 'PREVIOUS' named entity 'SARS-COV' named entity 'HIV' named entity 'SARS-LIKE CORONAVIRUS' named entity 'HERE' named entity 'VIRAL ENTRY' named entity 'POSSIBILITY' named entity 'GENETIC DIVERSITY' named entity 'DIFFERENT' named entity 'BAT' named entity 'TRUE' named entity 'HUMAN' named entity 'STUDIES' named entity 'FIELD' named entity 'COMPARISON' named entity 'ALTERATION' named entity 'MYOTIS DAUBENTONI' named entity 'DECREASED' named entity 'RESULTS' named entity 'LIVE' named entity 'SPECIES' named entity 'CONTINUATION' named entity 'BATS' named entity 'OUR' named entity 'DISCOVERY' named entity 'IDENTIFY' named entity 'EITHER' named entity 'ENHANCED' named entity 'SEVEN' named entity 'SURVEILLANCE' named entity 'KNOWN' named entity 'FUNCTIONAL' named entity 'SPECIES' named entity 'BAT' named entity 'ADDITIONAL' named entity 'POPULATIONS' named entity 'SARS-COV INFECTION' named entity 'GREATER THAN' named entity 'VIRUSES' named entity 'USING' named entity 'HOST' named entity 'THEIR' named entity 'SUPPORT' named entity 'RHINOLOPHUS SINICUS' named entity 'ACT' named entity 'NATURAL' named entity 'RECEPTOR' covid:arg/d421fc2ed42637e8d28b820f9ca2f2a837d39751 named entity 'EFFICIENCY' named entity 'MODELING' named entity 'COULD BE' named entity 'PREDICTED' named entity 'INTERACTIONS' named entity 'STRUCTURAL' named entity 'INDICATED' named entity 'PROTEINS' named entity 'SARS-COV' named entity 'VARIABLE' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'MAMMALS' named entity 'CURRENT' named entity 'OBSERVED' named entity 'KEY' named entity 'BASED'

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