About: The protective and pathogenic roles of IL-17 in viral infections: friend or foe?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The protective and pathogenic roles of IL-17 in viral infections: friend or foe?
Creator	Chen, De-Kun Ma, Wen-Tao Peng, Qun Yao, Xiao-Ting
Source	PMC
abstract	Viral infections cause substantial human morbidity and mortality, and are a significant health burden worldwide. Following a viral infection, the host may initiate complex antiviral immune responses to antagonize viral invasion and replication. However, proinflammatory antiviral immune responses pose a great threat to the host if not properly held in check. Interleukin (IL)-17 is a pleiotropic cytokine participating in a variety of physiological and pathophysiological conditions, including tissue integrity maintenance, cancer progression, autoimmune disease development and, more intriguingly, infectious diseases. Abundant evidence suggests that while IL-17 plays a crucial role in enhancing effective antiviral immune responses, it may also promote and exacerbate virus-induced illnesses. Accumulated experimental and clinical evidence has broadened our understanding of the seemingly paradoxical role of IL-17 in viral infections and suggests that IL-17-targeted immunotherapy may be a promising therapeutic option. Herein, we summarize current knowledge regarding the protective and pathogenic roles of IL-17 in viral infections, with emphasis on underlying mechanisms. The various and critical roles of IL-17 in viral infections necessitate the development of therapeutic strategies that are uniquely tailored to both the infectious agent and the infection environment.
has issue date	2019-07-24(xsd:dateTime)
bibo:doi	10.1098/rsob.190109
bibo:pmid	31337278
has license	cc-by
sha1sum (hex)	d43461482967a7b000596e2ebbf465b075dd4d1d
schema:url	https://doi.org/10.1098/rsob.190109
resource representing a document's title	The protective and pathogenic roles of IL-17 in viral infections: friend or foe?
has PubMed Central identifier	PMC6685926
has PubMed identifier	31337278
schema:publication	Open Biol
resource representing a document's body	covid:d43461482967a7b000596e2ebbf465b075dd4d1d#body_text
is schema:about of	named entity 'friend or foe' named entity 'IL-8' named entity 'mechanism of action' named entity 'clinical therapeutics' named entity 'HIV infection' named entity 'infection' named entity 'cirrhosis' named entity 'nuclear factor' named entity 'DCs' named entity 'total bilirubin' named entity 'infection' named entity 'occludin' named entity 'animal models' named entity 'viral infections' named entity 'hepatic fibrosis' named entity 'IL-7R' named entity 'HIV infection' named entity 'immunopathology' named entity 'IL-13' named entity 'IL-17' named entity 'Vitamin' named entity 'granulocyte-macrophage colony-stimulating factor' named entity 'IL-17' named entity 'lung' named entity 'IL-17' named entity 'IL-17' named entity 'IL-17' named entity 'IL-4' named entity 'pathology' named entity 'IL-17' named entity 'deficient mice' named entity 'serum levels' named entity 'vaccinia virus' named entity 'pathogenicity' named entity 'fibrotic' named entity 'T-cell' named entity 'mice' named entity 'therapeutic strategies' named entity 'Th17 cells' named entity 'plasma' named entity 'protein' named entity 'inflammation' named entity 'IL-17' named entity 'IL-17' named entity 'neonatal' named entity 'pulmonary fibrosis' named entity 'neutrophils' named entity 'vaccination' named entity 'treatment options' named entity 'proinflammatory' named entity 'α4β7 integrin' named entity 'SIV' named entity 'leucocytes' named entity 'neutrophils' named entity 'Treg' named entity 'hepatitis C virus' named entity 'infectious diseases' named entity 'infection' named entity 'amphiregulin' named entity 'growth factor' named entity 'IL-17R' named entity 'IL-10' named entity 'Th17 cells' named entity 'morbidity' named entity 'lung' named entity 'IL-17' named entity 'IgM' named entity 'viral infections' named entity 'HIV' named entity 'STAT1' named entity 'liver cirrhosis' named entity 'Th1' named entity 'indoleamine 2,3-dioxygenase' named entity 'Viral infections' named entity 'TSLP' named entity 'neutrophil' named entity 'viral infection' named entity 'Treg cell'

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