About: Serum IFN-γ–induced protein 10 (IP-10) as a biomarker for severity of acute respiratory infection in healthy adults

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About: Serum IFN-γ–induced protein 10 (IP-10) as a biomarker for severity of acute respiratory infection in healthy adults Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Serum IFN-γ–induced protein 10 (IP-10) as a biomarker for severity of acute respiratory infection in healthy adults
Creator	Barrett, Bruce Ewers, Tola Flannery, Sean Barnet, Jodi Champion, Heather Hayney, Mary Henriquez, Kelsey
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: The inflammatory chemokine, interferon-gamma inducible protein of 10 kDa (IP-10), is a biomarker associated with several conditions. OBJECTIVES: This study investigated serum concentrations of IP-10 in healthy individuals who developed acute respiratory infection (ARI). The hypothesis is that serum IP-10 concentrations correlate with ARI severity and detection of viral pathogens. STUDY DESIGN: Data come from a randomized controlled trial measuring the effects of mindfulness meditation or exercise on ARI (Clinical Trials ID: NCT01654289). Healthy adults ages 30–69 were followed for a single season for ARI incidence and severity. This trial is ongoing, and the investigators are still blinded. When a participant reported ARI symptoms, nasal swab and lavage for PCR-based viral identification and blood samples were collected within the first 72 hours of ARI symptoms. Serum IP-10 concentrations were measured by ELISA (R&D Systems, Inc. Quantikine ELISA, Minneapolis, MN). ARI severity was measured using the validated Wisconsin Upper Respiratory Symptom Survey (WURSS-24) until the ARI episode resolved. RESULTS: Serum IP-10 concentrations from 225 ARI episodes correlated with ARI global severity (rho 0.28 [95% CI: 0.15–0.39]; p<0.001). IP-10 concentrations were higher with an ARI in which a viral pathogen was detected compared to no viral pathogen detected (median 366 pg/ml [IQR: 227–486] vs 163 pg/ml [IQR: 127–295], p<0.0001). Influenza infections had higher IP-10 concentrations than coronavirus, enterovirus or rhinovirus, and paramyxovirus. CONCLUSION: Serum IP-10 concentration correlates with ARI global severity. Also, IP-10 concentration measured early in the course of the ARI correlates with the daily severity, duration, and illness symptoms.
has issue date	2017-05-01(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2017.03.003
bibo:pmid	28334685
has license	green-oa
sha1sum (hex)	d437a204943daa53e0d7c1f218ae33d14d744ee9
schema:url	https://doi.org/10.1016/j.jcv.2017.03.003
resource representing a document's title	Serum IFN-γ–induced protein 10 (IP-10) as a biomarker for severity of acute respiratory infection in healthy adults
has PubMed Central identifier	PMC5408957
has PubMed identifier	28334685
schema:publication	Journal of Clinical Virology
resource representing a document's body	covid:d437a204943daa53e0d7c1f218ae33d14d744ee9#body_text
is schema:about of	named entity 'IFN' named entity 'INVESTIGATED' named entity 'HEALTHY' named entity 'DETECTION' named entity 'ARI' named entity 'INDUCIBLE' named entity 'VIRAL PATHOGENS' named entity 'SEVERITY' named entity 'PROTEIN ' named entity 'INTERFERON-GAMMA' named entity 'ACUTE RESPIRATORY INFECTION' named entity 'ASSOCIATED WITH' named entity 'INDIVIDUALS' named entity 'CONDITIONS' named entity 'STUDY' named entity 'IS A' named entity 'BIOMARKER' named entity 'SERUM' named entity 'IP-10' named entity 'BACKGROUND' named entity 'OBJECTIVES' named entity 'BIOMARKER' named entity 'ADULTS' named entity 'PROTEIN ' named entity 'HYPOTHESIS' named entity 'HEALTHY' named entity 'SERUM' named entity '10%' named entity 'SEVERITY' named entity 'ACUTE RESPIRATORY INFECTION' named entity 'INDUCED' named entity 'KDA' named entity 'CONCENTRATIONS' named entity '10%' named entity 'INFLAMMATORY CHEMOKINE' covid:arg/d437a204943daa53e0d7c1f218ae33d14d744ee9 named entity 'kDa' named entity 'chemokine' named entity 'protein' named entity 'correlate' named entity 'protein' named entity 'kDa' named entity 'IP-10' named entity 'ARI' named entity 'ARI' named entity 'acute respiratory infection' named entity 'protein' named entity 'biomarker' named entity 'ARIs' named entity 'serotypes' named entity 'IP-10' named entity 'rhinovirus' named entity 'inflammatory' named entity 'Influenza' named entity '95% confidence interval' named entity 'blood draw' named entity '95% CI' named entity 'insulin resistance' named entity 'gene' named entity 'IP-10' named entity 'respiratory syncytial viruses' named entity 'IP-10' named entity 'IP-10' named entity 'viral pathogen' named entity 'symptom' named entity 'sneezing' named entity 'IP-10' named entity 'IP-10' named entity 'endothelial cells' named entity 'serum' named entity 'interferon-gamma' named entity 'angiogenesis' named entity 'adenovirus' named entity 'BMI' named entity 'ARIs'

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