About: Association of common comorbidities with osteonecrosis: a nationwide population-based case

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About: Association of common comorbidities with osteonecrosis: a nationwide population-based case–control study in Denmark Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Association of common comorbidities with osteonecrosis: a nationwide population-based case–control study in Denmark
Creator	Baicus, Cristian Dima, Alina Pedersen, Lars Authors, Thomsen Baicus, ; Pedersen, ; Pedersen, Alma Thomsen Rw, ; Wernich, Reimar
source	Medline; PMC
abstract	OBJECTIVE: To examine recent time trends in the incidence of osteonecrosis (ON) in Denmark and to investigate different common comorbidities association with ON in a population-based setting. METHODS: Using Danish medical databases, we included all patients with a first-time hospital diagnosis of ON during 1995–2012. Each ON case was matched with 10 randomly selected population control subjects from general population. For all participants, we obtained a complete hospital history of comorbidities included in the CharlsonComorbidity Index 5 years preceding the inclusion date. RESULTS: 4107 ON cases and 41 063 controls were included. The incidence of ON increased from 3.9 in 1995 to 5.5 in 2012 per 100 000 inhabitants. Solid cancer was the most common comorbidity, associated with an adjusted OR (aOR) for ON of 2.0 (95% CI 1.7 to 2.2). For advanced metastatic cancer, leukaemia and lymphoma, aORs of ON were 3.4 (95% CI 2.5 to 4.5), 4.3 (95% CI 2.7 to 7.0) and 5.8 (95% CI 4.3 to 7.8), respectively. Among other chronic conditions, aORs were 3.5 (95% CI 3.0 to 4.1) for connective tissue diseases and 2.3 (95% CI 2.0 to 2.7) for chronic pulmonary diseases. aORs were also increased at 2.8 (95% CI 1.9 to 4.1) and 4.5 (95% CI 2.5 to 8.2) for mild and moderate-to-severe liver disease, respectively, and 4.2 (95% CI 3.4 to 5.2) for renal disease. CONCLUSION: This large population-based study provides evidence for an increasing ON incidence in the general population and documents an association between several common comorbid conditions and risk of ON.
has issue date	2018-02-08(xsd:dateTime)
bibo:doi	10.1136/bmjopen-2017-020680
bibo:pmid	29439082
has license	cc-by-nc
sha1sum (hex)	d43c9028fc460b667d7b8e54c16f0a85de6f3c4d
schema:url	https://doi.org/10.1136/bmjopen-2017-020680
resource representing a document's title	Association of common comorbidities with osteonecrosis: a nationwide population-based case–control study in Denmark
has PubMed Central identifier	PMC5829903
has PubMed identifier	29439082
schema:publication	BMJ Open
resource representing a document's body	covid:d43c9028fc460b667d7b8e54c16f0a85de6f3c4d#body_text
is schema:about of	named entity 'Case' named entity 'Osteonecrosis' named entity 'STUDY' named entity 'COMMON' named entity 'DENMARK' named entity 'COMORBIDITIES' named entity 'TRENDS' named entity 'TIME' named entity 'TO EXAMINE' named entity 'BASED' named entity 'INCIDENCE' named entity 'OSTEONECROSIS' named entity 'CASE' named entity 'ASSOCIATION' named entity 'POPULATION' named entity 'COMORBIDITIES' named entity 'DIFFERENT' named entity 'RECENT' named entity 'TO INVESTIGATE' named entity 'SETTING' named entity 'POPULATION' named entity 'COMMON' named entity 'ASSOCIATION' named entity 'OBJECTIVE' named entity 'OSTEONECROSIS' named entity 'public health' named entity 'leukemia' named entity 'severe liver disease' named entity 'chronic pulmonary disease' named entity 'osteonecrosis' named entity 'comorbid conditions' named entity 'Denmark' named entity 'osteonecrosis' named entity 'ethnicity' named entity 'CCI' named entity 'selection bias' named entity 'Denmark' named entity 'study population' named entity 'CCI' named entity 'comorbidity' named entity '13.1' named entity 'renal disease' named entity 'confounders' named entity 'diagnostic tools' named entity 'chronic pulmonary disease' named entity 'malignancies' named entity 'cerebrovascular disease' named entity 'Statistics Denmark' named entity 'relative risk' named entity 'aseptic' named entity 'SAS statistical software' named entity 'liver' named entity 'Solid cancer' named entity 'recall bias' named entity 'hematological cancers' named entity 'CCI' named entity 'general population' named entity 'CCI' named entity 'relative risk' named entity '5.2' named entity 'Denominator data' named entity 'Denmark' named entity 'osteonecrosis' named entity 'Denmark' named entity 'odds ratios' named entity 'relative risk' named entity 'randomly selected' named entity 'comorbidity' named entity 'malignancies' named entity 'alcohol' named entity 'Cary, NC' named entity 'metastatic cancers' named entity '4.2'

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