About: Infectious agents and age-related neurodegenerative disorders

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Infectious agents and age-related neurodegenerative disorders
Creator	Mattson, Mark
Source	Elsevier; Medline; PMC
abstract	As with other organ systems, the vulnerability of the nervous system to infectious agents increases with aging. Several different infectious agents can cause neurodegenerative conditions, with prominent examples being human immunodeficiency virus (HIV-1) dementia and prion disorders. Such infections of the central nervous system (CNS) typically have a relatively long incubation period and a chronic progressive course, and are therefore increasing in frequency as more people live longer. Infectious agents may enter the central nervous system in infected migratory macrophages, by transcytosis across blood–brain barrier cells or by intraneuronal transfer from peripheral nerves. Synapses and lipid rafts are important sites at which infectious agents may enter neurons and/or exert their cytotoxic effects. Recent findings suggest the possibility that infectious agents may increase the risk of common age-related neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and stroke. While scenarios can be envisioned whereby viruses such as Chlamydia pneumoniae, herpes simplex and influenza promote damage to neurons during aging, there is no conclusive evidence for a major role of these pathogens in neurodegenerative disorders. In the case of stroke, blood vessels may be adversely affected by bacteria or viruses resulting in atherosclerosis.
has issue date	2003-11-05(xsd:dateTime)
bibo:doi	10.1016/j.arr.2003.08.005
bibo:pmid	15163105
has license	no-cc
sha1sum (hex)	d486e10502c9a5ad3823b45e72c7049f5e26667f
schema:url	https://doi.org/10.1016/j.arr.2003.08.005
resource representing a document's title	Infectious agents and age-related neurodegenerative disorders
has PubMed Central identifier	PMC7172323
has PubMed identifier	15163105
schema:publication	Ageing Res Rev
resource representing a document's body	covid:d486e10502c9a5ad3823b45e72c7049f5e26667f#body_text
is schema:about of	named entity 'organ systems' named entity 'enter' named entity 'stroke' named entity 'sites' named entity 'TRANSFER' named entity 'MIGRATORY' named entity 'THESE' named entity 'LIPID RAFTS' named entity 'FINDINGS' named entity 'neurodegenerative' named entity 'possibility' named entity 'infectious agents' named entity 'infectious agents' named entity 'incubation period' named entity 'conclusive evidence' named entity 'peripheral nerves' named entity 'Chlamydia pneumoniae' named entity 'atherosclerosis' named entity 'bacteria' named entity 'neurons' named entity 'Alzheimer's disease' named entity 'amyotrophic lateral sclerosis' named entity 'dementia' named entity 'live longer' named entity 'neurodegenerative conditions' named entity 'organ systems' named entity 'human immunodeficiency virus' named entity 'Infectious agents' named entity 'neurodegenerative disorders' named entity 'damage' named entity 'ALS' named entity 'GTP-binding proteins' named entity 'neural cells' named entity 'synapses' named entity 'sphingomyelin' named entity 'motor dysfunction' named entity 'atherosclerosis' named entity 'ALS' named entity 'viral infections' named entity 'dementia' named entity 'immune responses' named entity 'atherosclerosis' named entity 'cognitive impairment' named entity 'Chlamydia pneumoniae' named entity 'PrPsc' named entity 'tuberculosis' named entity 'ion' named entity 'PrPc' named entity 'DNA sequences' named entity 'immune function' named entity 'pathogenesis' named entity 'cerebrospinal fluid' named entity 'oxidative stress' named entity 'infectious agents' named entity 'NF-B' named entity 'control subjects' named entity 'apoptosis' named entity 'Microglia' named entity 'atherosclerotic' named entity 'GPI-anchored' named entity 'apoptosis' named entity 'TNF' named entity 'PrPc' named entity 'Sindbis' named entity 'microglia' named entity 'immunization' named entity 'cytokines' named entity 'inflammatory processes' named entity 'macrophages' named entity 'human herpes virus' named entity 'stroke' named entity 'antiretroviral therapy' named entity 'multiple sclerosis' named entity 'prion' named entity 'nervous systems' named entity 'age-related' named entity 'blood vessels' named entity 'calcium influx' named entity 'type 1' named entity 'caloric intake' named entity 'Ca2+'

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