About: SOFIA(®)RSV: prospective laboratory evaluation and implementation of a rapid diagnostic test in a pediatric emergency ward

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About: SOFIA(®)RSV: prospective laboratory evaluation and implementation of a rapid diagnostic test in a pediatric emergency ward Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SOFIA(®)RSV: prospective laboratory evaluation and implementation of a rapid diagnostic test in a pediatric emergency ward
Creator	Brouard, Jacques Vabret, Astrid Dina, Julia Morello, Rémy Tournus, Céline Tran, Léa
Source	Medline; PMC
abstract	BACKGROUND: Respiratory syncytial virus (RSV) is responsible for severe respiratory infections and higher costs in medical care. The two aims of this work were to assess the performances of SOFIA(®)RSV tests in “real-life-laboratory” conditions (study 1) and implemented at point-of-care testing in a pediatric emergency department (ED, study 2), during two consecutive winter seasons. METHODS: In study 1, fresh nasopharyngeal swabs from patients of all ages were sampled in 1.5 ml of Universal virological Transport Medium (UTM) and prospectively tested using SOFIA(®)RSV tests. In study 2, conducted in a pediatric ED, nasopharyngeal swabs were placed in 3 ml of UTM. All SOFIA(®)RSV tests were confirmed by molecular testing, considered as reference method. The epidemiological and clinical features of tested patients, as well as the care of these patients after obtaining quick results were evaluated. RESULTS: The sensitivities of SOFIA(®)RSV in infants (aged under 24 months) performed in the laboratory and in the pediatric ED were respectively 95% (95% CI: 86.8–98.1) and 74.8% (95% CI: 68.0–80.9) compared to PCR. In study 1, the sensitivity among children (from 2 to 15 years old) and adults (above 15 years old) dropped to 45% (95% CI: 23.1–68.5) and 59% (95% CI: 32.9–81.6), respectively. In study 2, there were some differences in bed-management of SOFIA(®)RSV positive compared to SOFIA(®)RSV negative infants. CONCLUSIONS: SOFIA(®)RSV tests performed in the laboratory and in the pediatric ED show high and satisfactory sensitivities among young children under 24 months, which supports its robustness and reliability. However, the impact of these tests on patient care at point-of-care cannot be clearly assessed when considering the limits of the study 2 design. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-017-2557-8) contains supplementary material, which is available to authorized users.
has issue date	2017-06-26(xsd:dateTime)
bibo:doi	10.1186/s12879-017-2557-8
bibo:pmid	28651525
has license	cc-by
sha1sum (hex)	d49fa4e23c46606bdaccc8744bc75b2fc2700df9
schema:url	https://doi.org/10.1186/s12879-017-2557-8
resource representing a document's title	SOFIA(®)RSV: prospective laboratory evaluation and implementation of a rapid diagnostic test in a pediatric emergency ward
has PubMed Central identifier	PMC5485495
has PubMed identifier	28651525
schema:publication	BMC Infect Dis
resource representing a document's body	covid:d49fa4e23c46606bdaccc8744bc75b2fc2700df9#body_text
is schema:about of	named entity 'patients' named entity 'nasopharyngeal' named entity 'study' named entity 'quick' named entity 'study' named entity 'SOFIA' named entity 'rapid diagnostic test' named entity 'WINTER' named entity 'SOFIA' named entity 'EVALUATED' named entity 'FRESH' named entity 'SEVERE' named entity 'QUICK' named entity 'CONSECUTIVE' named entity 'UNIVERSAL' named entity 'RSV' named entity 'RESPIRATORY INFECTIONS' named entity 'SAMPLED' named entity 'LIFE' named entity 'swabs' named entity 'assess' named entity 'winter' named entity 'tested' named entity 'tested' named entity 'seasons' named entity 'SOFIA' named entity 'SOFIA' named entity 'medical care' named entity 'point-of-care testing' named entity 'respiratory infections' named entity 'reference method' named entity 'emergency department' named entity 'RSV' named entity 'Respiratory syncytial virus' named entity 'RSV' named entity 'clinical features' named entity 'tests' named entity '5.5' named entity 'confidence intervals' named entity 'POCT' named entity 'inoculated' named entity 'RSV' named entity 'statistically significant' named entity 'RSV' named entity 'SOFIA' named entity 'PCR' named entity 'pathogens' named entity 'antibiotics' named entity 'aerosol' named entity 'SOFIA' named entity 'general pediatrics' named entity 'corticosteroids' named entity 'RSV' named entity 'RSV' named entity 'positive correlation' named entity 'enterovirus' named entity 'ciliated cells' named entity 'epinephrine' named entity 'POCT' named entity 'temperate regions' named entity 'PCR' named entity 'pediatric' named entity 'general pediatrics' named entity 'general pediatrics' named entity 'upper respiratory tract' named entity 'POCT' named entity 'RSV' named entity 'immunomodulators' named entity 'POCT' named entity 'bronchiolitis' named entity 'multiplex PCR' named entity 'RSV' named entity 'rapid diagnostic tests' named entity 'Biomerieux' named entity 'RSV' named entity 'pediatric intensive care unit'

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