About: Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin‐8 in nasal lavage in asthmatic subjects in vivo

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About: Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin‐8 in nasal lavage in asthmatic subjects in vivo Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin‐8 in nasal lavage in asthmatic subjects in vivo
Creator	Sterk, P De Klerkf, E Grunberg, K Hiemstra, P Smits, Spaant, E Timmers, M
Source	PMC
abstract	Background Asthma exacerbations are closely associated with respiratory virus infections. However, the pathophysiological consequences of such infections in asthma are largely unclear. Objective To examine the effect of rhinovirus 16 (RV16) infection on airway hypersensitivity to histamine. and on interleukin‐8 (IL‐8) in nasal lavage. Objective Twenty‐seven non‐smoking atopic, mildly asthmatic subjects participated in a placebo‐controlled, parallel study. A dose of 0.5–2.9 ± 10(4) TCID50 RV16 or placebo was nasally administered. Cold symptoms were recorded by questionnaire throughout the study. Histamine challenges were performed at entry, and on days 4 and 11 after inoculation. Nasal lavages were obtained at entry, and on days 2 and 9. The response to histamine was measured by PC(20) (changes expressed as doubling doses: DD). IL‐8 levels were obtained by ELISA, and were expressed in ng/ml. Results RV infection was confirmed by culture of nasal lavage and/or by antibody titre rise in each of the RV16‐treated subjects. Among the 19 RV16‐treated subjects, eight developed severe cold symptoms. Baseline FEV(1) did not change significantly during the study in either treatment group (P= 0.99). However, in the RV16‐treated subjects there was a decrease in PC(20) at day 4, which was most pronounced in those with a severe cold (mean change ± SEM: –1.14 ± 0.28 DD, P= 0.01). In addition. IL‐8 levels increased in tbe RV16 group at days 2 and 9 (P < 0.001). The increase in nasal IL‐8 at day 2 correlated significantly with the change in PC(20) at day 4 (r=–0.48, P= 0.04). Conclusion We conclude that the severity of cold, as induced by experimental RV16 infection, is a determinant of the increase in airway hypersensitivity to histamine in patients with asthma. Our results suggest that this may be mediated by an infiammatory mechanism, involving the release of chemokines such as IL‐8.
has issue date	2006-04-27(xsd:dateTime)
bibo:doi	10.1111/j.1365-2222.1997.tb00670.x
bibo:pmid	9117878
has license	no-cc
sha1sum (hex)	d4b3ad82efd56ddf9f1ed3dc6525071e4a349684
schema:url	https://doi.org/10.1111/j.1365-2222.1997.tb00670.x
resource representing a document's title	Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin‐8 in nasal lavage in asthmatic subjects in vivo
has PubMed Central identifier	PMC7164827
has PubMed identifier	9117878
schema:publication	Clin Exp Allergy
resource representing a document's body	covid:d4b3ad82efd56ddf9f1ed3dc6525071e4a349684#body_text
is schema:about of	named entity 'levels' named entity 'subjects' named entity 'determinant' named entity 'cold' named entity 'respiratory' named entity 'patients' named entity 'pathophysiological' named entity 'questionnaire' named entity 'Methods' named entity 'interleukin' named entity 'inoculation' named entity 'infections' named entity 'doses' named entity 'study' named entity 'interleukin' named entity 'treated' named entity 'Background' named entity 'group' named entity 'hypersensitivity' named entity 'hypersensitivity' named entity 'study' named entity 'histamine' named entity 'Results' named entity 'histamine' named entity 'rise' named entity 'TCID50' named entity 'virus infections' named entity 'asthmatic' named entity 'pathophysiological' named entity 'inoculation' named entity 'hypersensitivity' named entity 'interleukin-8' named entity 'IL-8' named entity 'airway' named entity 'nasal lavage' named entity 'infection' named entity 'treatment group' named entity 'rhinovirus' named entity 'rhinovirus' named entity 'histamine' named entity 'asthmatic' named entity 'MANOVA' named entity '1.14' named entity 'cough' named entity 'severe cold' named entity 'common cold' named entity 'virus' named entity 'asthmatic' named entity 'severe cold' named entity 'fibroblast' named entity 'lavage' named entity 'rhinovirus' named entity 'histamine' named entity 'allergen' named entity 'epidemiological' named entity 'analysis of variance' named entity 'interleukin-8' named entity 'blood count' named entity 'asthma exacerbation' named entity 'IL-8' named entity 'virus infections' named entity 'chemokines' named entity 'nostril' named entity 'infection' named entity 'placebo' named entity 'inoculation' named entity 'allergens' named entity 'cytokines' named entity 'inhalation' named entity 'rhinovirus' named entity 'correlation' named entity 'allergen' named entity 'asthma' named entity 'IL-8' named entity 'interleukin-1'

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