About: Importance of Akt signaling pathway for apoptosis in SARS-CoV-infected Vero E6 cells

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About: Importance of Akt signaling pathway for apoptosis in SARS-CoV-infected Vero E6 cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Importance of Akt signaling pathway for apoptosis in SARS-CoV-infected Vero E6 cells
Creator	Mizutani, Tetsuya Fukushi, Shuetsu Morikawa, Shigeru Saijo, Masayuki Kurane, Ichiro
source	Elsevier; Medline; PMC
abstract	Abstract Severe acute respiratory syndrome (SARS) is an acute respiratory tract infectious disease that is associated with a new coronavirus (SARS-CoV). Our recent study indicated that SARS-CoV infection induces activation of the p38 mitogen-activated protein kinase (MAPK) signaling pathway and the p38 MAPK inhibitor partially inhibited its cytopathic effect in Vero E6 cells. The results of the present study indicated that before cell death, Akt, which is an inhibitor of apoptosis, was also activated in response to viral replication. Phosphorylation of a serine residue on Akt was detected at least 8 h postinfection (hpi), which declined after 18 hpi. Thus, the phosphatidylinositol 3-kinase (PI3K)/Akt pathway is activated in virus-infected Vero E6 cells. However, a threonine residue was not phosphorylated. A downstream target of Akt, glycogen synthase kinase 3β (GSK-3β), was slightly phosphorylated, indicating that the level of activation of Akt was very low. PKCζ, which is downstream of the PI3K pathway, was also phosphorylated in virus-infected cells. These results suggested that weak activation of Akt cannot prevent apoptosis induced by SARS-CoV infection in Vero E6 cells.
has issue date	2004-10-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2004.07.005
bibo:pmid	15351204
has license	els-covid
sha1sum (hex)	d4b7462036624ff4ff8d160a74e2cee47386944f
schema:url	https://doi.org/10.1016/j.virol.2004.07.005
resource representing a document's title	Importance of Akt signaling pathway for apoptosis in SARS-CoV-infected Vero E6 cells
has PubMed Central identifier	PMC7111732
has PubMed identifier	15351204
schema:publication	Virology
resource representing a document's body	covid:d4b7462036624ff4ff8d160a74e2cee47386944f#body_text
is schema:about of	named entity 'INFECTED' named entity 'p38' named entity 'respiratory tract' named entity 'infection' named entity 'Vero' named entity 'Vero' named entity 'signaling pathway' named entity 'APOPTOSIS' named entity 'PHOSPHORYLATED' named entity 'INHIBITOR' named entity 'MAPK INHIBITOR' named entity 'PREVENT' named entity 'NEW' named entity 'ITS' named entity 'GLYCOGEN SYNTHASE KINASE' named entity 'SERINE RESIDUE' named entity 'INDICATED' named entity 'VIRAL REPLICATION' named entity 'TARGET' named entity 'LEVEL' named entity 'THREONINE RESIDUE' named entity 'RESPONSE TO' named entity 'PKC' named entity 'CYTOPATHIC EFFECT' named entity 'THESE' named entity 'PARTIALLY' named entity 'RESULTS' named entity 'STUDY' named entity 'APOPTOSIS' named entity 'SLIGHTLY' named entity 'SARS-COV' named entity 'ACUTE' named entity 'PI3K PATHWAY' named entity 'WEAK' named entity 'PATHWAY' named entity 'ACTIVATED' named entity 'INDUCED' named entity 'PHOSPHORYLATION' named entity 'PRESENT' named entity 'SIGNALING PATHWAY' named entity 'VERO' named entity 'INFECTED' named entity 'ASSOCIATED WITH' named entity 'AKT SIGNALING PATHWAY' named entity 'P38 MITOGEN-ACTIVATED PROTEIN KINASE' named entity 'DETECTED' named entity 'INHIBITED' named entity 'CELL DEATH' named entity 'CELLS' named entity 'INDICATING' named entity 'HPI' named entity 'VERY LOW' named entity 'P38 MAPK' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'ACTIVATION' named entity 'CORONAVIRUS' named entity 'PHOSPHATIDYLINOSITOL 3-KINASE' named entity 'DOWNSTREAM' named entity 'RECENT' named entity 'VIRUS' named entity 'AKT' named entity 'CELLS' named entity 'VERO' named entity 'RESPIRATORY TRACT INFECTIOUS DISEASE' named entity 'OUR' covid:arg/d4b7462036624ff4ff8d160a74e2cee47386944f named entity 'activation' named entity 'SARS-CoV' named entity 'infection' named entity 'Thus' named entity 'activated' named entity 'Akt' named entity 'phosphatidylinositol 3-kinase' named entity 'Vero E6' named entity 'virus' named entity 'phosphorylated' named entity 'inhibitor of apoptosis'

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