About: A subcutaneously injected UV-inactivated SARS coronavirus vaccine elicits systemic humoral immunity in mice

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About: A subcutaneously injected UV-inactivated SARS coronavirus vaccine elicits systemic humoral immunity in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A subcutaneously injected UV-inactivated SARS coronavirus vaccine elicits systemic humoral immunity in mice
Creator	Morikawa, Shigeru Tashiro, Masato Odagiri, Takato Itamura, Shigeyuki Ishii, Koji Takemori, Toshitada Tsunetsugu-Yokota, Yasuko Fujii, Hideki Sakaguchi, Masahiro Ohnishi, Kazuo Hashimoto, Shu-Ichi Kasai, Masataka Ohshima, Masamichi Takahashi, Yoshimasa Takasuka, Naomi Yoshikura, Hiroshi
Source	Medline; PMC
abstract	The recent emergence of severe acute respiratory syndrome (SARS) was caused by a novel coronavirus, SARS-CoV. It spread rapidly to many countries and developing a SARS vaccine is now urgently required. In order to study the immunogenicity of UV-inactivated purified SARS-CoV virion as a vaccine candidate, we subcutaneously immunized mice with UV-inactivated SARS-CoV with or without an adjuvant. We chose aluminum hydroxide gel (alum) as an adjuvant, because of its long safety history for human use. We observed that the UV-inactivated SARS-CoV virion elicited a high level of humoral immunity, resulting in the generation of long-term antibody secreting and memory B cells. With the addition of alum to the vaccine formula, serum IgG production was augmented and reached a level similar to that found in hyper-immunized mice, though it was still insufficient to elicit serum IgA antibodies. Notably, the SARS-CoV virion itself was able to induce long-term antibody production even without an adjuvant. Anti-SARS-CoV antibodies elicited in mice recognized both the spike and nucleocapsid proteins of the virus and were able to neutralize the virus. Furthermore, the UV-inactivated virion induced regional lymph node T-cell proliferation and significant levels of cytokine production (IL-2, IL-4, IL-5, IFN-γ and TNF-α) upon restimulation with inactivated SARS-CoV virion in vitro. Thus, a whole killed virion could serve as a candidate antigen for a SARS vaccine to elicit both humoral and cellular immunity.
has issue date	2004-08-16(xsd:dateTime)
bibo:doi	10.1093/intimm/dxh143
bibo:pmid	15314040
has license	no-cc
sha1sum (hex)	d4c94f0e8c4f570af90671b0fa790d59e5140ef0
schema:url	https://doi.org/10.1093/intimm/dxh143
resource representing a document's title	A subcutaneously injected UV-inactivated SARS coronavirus vaccine elicits systemic humoral immunity in mice
has PubMed Central identifier	PMC7108621
has PubMed identifier	15314040
schema:publication	Int Immunol
resource representing a document's body	covid:d4c94f0e8c4f570af90671b0fa790d59e5140ef0#body_text
is schema:about of	named entity 'vaccine' named entity 'study' named entity 'IgG' named entity 'vaccine' named entity 'observed' named entity 'T-cell' named entity 'CAUSED BY' named entity 'T-CELL PROLIFERATION' named entity 'IFN' named entity 'EMERGENCE' named entity 'ELICITED' named entity 'SARS-COV' named entity 'VIRION' named entity 'OBSERVED' named entity 'REQUIRED' named entity 'INSUFFICIENT' named entity 'CYTOKINE PRODUCTION' named entity 'HISTORY' named entity 'REGIONAL LYMPH NODE' named entity 'IN VITRO' named entity 'NOVEL CORONAVIRUS' named entity 'VACCINE' named entity 'CHOSE' named entity 'GENERATION' named entity 'LEVELS' named entity 'SIGNIFICANT' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'CANDIDATE' named entity 'ADDITION' named entity 'IMMUNIZED' named entity 'STUDY' named entity 'INACTIVATED' named entity 'LONG' named entity 'FOUND' named entity 'TNF-A' named entity 'LEVEL' named entity 'ITS' named entity 'CELLULAR IMMUNITY' named entity 'DEVELOPING' named entity 'ALUM' named entity 'ANTIGEN' named entity 'ANTIBODY PRODUCTION' named entity 'SAFETY' named entity 'KILLED' named entity 'RESULTING IN' named entity 'IL-4' named entity 'FORMULA' named entity 'RAPIDLY' named entity 'INDUCE' named entity 'SPREAD' named entity 'SIMILAR' named entity 'INACTIVATED' named entity 'SARS CORONAVIRUS' named entity 'CORONAVIRUS VACCINE' named entity 'HUMORAL IMMUNITY' named entity 'NUCLEOCAPSID PROTEINS' named entity 'SERVE' named entity 'SECRETING' named entity 'VACCINE CANDIDATE' named entity 'HUMORAL IMMUNITY' named entity 'ELICITS' named entity 'LONG-TERM' named entity 'MICE' named entity 'HYPER' named entity 'MEMORY B CELLS' named entity 'HUMAN USE'

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