About: Epidemiology and clinical profile of pathogens responsible for the hospitalization of children in Sousse area, Tunisia

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About: Epidemiology and clinical profile of pathogens responsible for the hospitalization of children in Sousse area, Tunisia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epidemiology and clinical profile of pathogens responsible for the hospitalization of children in Sousse area, Tunisia
Creator	Stoiber, Heribert Boughamoura, Lamia Boukadida, Jalel Guerrero, Aida Hannachi, Naila Schiela, Britta Borena, Wegene Bouguila, Jihene Bouhlel, Amira Brini, Ines Hetzer, Benjamin Laer, Dorothee Orth-Hö Ller, Dorothea
Source	Medline; PMC
abstract	This study aimed to identify a broad spectrum of respiratory pathogens from hospitalized and not-preselected children with acute respiratory tract infections in the Farhat Hached University-hospital of Sousse, Tunisia. Between September 2013 and December 2014, samples from 372 children aged between 1 month and 5 years were collected, and tested using multiplex real-time RT-PCR by a commercial assay for 21 respiratory pathogens. In addition, samples were screened for the presence of Streptococcus pneumoniae 16S rDNA using real-time PCR. The viral distribution and its association with clinical symptoms were statistically analyzed. Viral pathogens were detected in 342 (91.93%) of the samples of which 28.76% were single positive and 63.17% had multiple infections. The most frequent detected viruses were rhinovirus (55.64%), respiratory syncytial virus A/B (33.06%), adenovirus (25.00%), coronavirus NL63, HKU1, OC43, and 229E (21.50%), and metapneumovirus A/B (16.12%). Children in the youngest age group (1–3 months) exhibited the highest frequencies of infection. Related to their frequency of detection, RSV A/B was the most associated pathogen with patient’s demographic situation and clinical manifestations (p<0.05). Parainfluenza virus 1–4 and parechovirus were found to increase the risk of death (p<0.05). Adenovirus was statistically associated to the manifestation of gastroenteritis (p = 0.004). Rhinovirus infection increases the duration of oxygen support (p = 0.042). Coronavirus group was statistically associated with the manifestation of bronchiolitis (p = 0.009) and laryngitis (p = 0.017). Streptococcus pneumoniae DNA was detected in 143 (38.44%) of tested samples. However, only 53 samples had a concentration of C-reactive protein from equal to higher than 20 milligrams per liter, and 6 of them were single positive for Streptocuccus pneumoniae. This study confirms the high incidence of respiratory viruses in children hospitalized for acute respiratory tract infections in the Sousse area, Tunisia.
has issue date	2017-11-17(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0188325
bibo:pmid	29149199
has license	cc-by
sha1sum (hex)	d4f00f66c732c292fcfc28b19f44daa2fa620901
schema:url	https://doi.org/10.1371/journal.pone.0188325
resource representing a document's title	Epidemiology and clinical profile of pathogens responsible for the hospitalization of children in Sousse area, Tunisia
has PubMed Central identifier	PMC5693464
has PubMed identifier	29149199
schema:publication	PLoS One
resource representing a document's body	covid:d4f00f66c732c292fcfc28b19f44daa2fa620901#body_text
is schema:about of	covid:arg/d4f00f66c732c292fcfc28b19f44daa2fa620901 named entity 'respiratory syncytial virus' named entity 'bronchiolitis' named entity 'NL63' named entity '1.000' named entity 'metapneumovirus' named entity 'parechovirus' named entity 'Viral pathogens' named entity 'Streptococcus pneumoniae' named entity '1.000' named entity 'broad spectrum' named entity '1.000' named entity '1.000' named entity 'Sousse' named entity 'Tunisia' named entity 'Anemia' named entity 'assay' named entity 'oxygen support' named entity 'PLOS ONE' named entity 'viral infection' named entity 'coronavirus' named entity 'respiratory tract infections' named entity 'risk of death' named entity '1.000' named entity 'Tunisia' named entity 'denaturation' named entity 'Hydrocortisone' named entity 'gastroenteritis' named entity 'viral infection' named entity 'qPCR' named entity 'Haemophilus influenzae' named entity 'reverse transcription' named entity 'Sousse' named entity 'fungi' named entity 'Tunisia' named entity 'binary logistic regression' named entity 'viruses' named entity 'qPCR' named entity '8 days' named entity 'pathogens' named entity 'Tunisia' named entity 'PCR' named entity 'Farhat Hached' named entity 'clinical symptoms' named entity 'antibiotics' named entity 'intensive care unit' named entity 'virus' named entity 'causative agent' named entity 'viral infection' named entity 'S. pneumoniae' named entity 'qPCR' named entity 'reference group' named entity 'Morocco' named entity 'viral infections' named entity 'LRTI' named entity 'PeV' named entity 'S. pneumoniae' named entity 'Thermocycling' named entity 'nucleic acids' named entity 'real-time PCR' named entity 'health concern' named entity 'viruses' named entity 'virus' named entity 'University-hospital' named entity 'respiratory illness' named entity 'University-hospital' named entity 'PeV' named entity 'URTIs' named entity 'RSV'

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