About: Antibody responses to individual proteins of SARS coronavirus and their neutralization activities

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Antibody responses to individual proteins of SARS coronavirus and their neutralization activities
Creator	Wang, Jian Shi, Yuling Wang, Xiaoyi Yang, Ruifu Liu, Ying Zhang, Yong Zhai, Junhui Wang, Jin Sun, Bing Si, Bingyin Yang, Ling Chen, Zeliang Dai, Erhei Du, Zongmin Guo, Zhaobiao Pang, Xin Wang, Hongxia Zhou, Dongsheng Qiu, Maofeng Li, Jingxiang Song, Yajun Chen, Runsheng Li, Linhai He, Rongqiao
source	Elsevier; Medline; PMC
abstract	A novel coronavirus, the severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV), was identified as the causative agent of SARS. The profile of specific antibodies to individual proteins of the virus is critical to the development of vaccine and diagnostic tools. In this study, 13 recombinant proteins associated with four structural proteins (S, E, M and N) and five putative uncharacterized proteins (3a, 3b, 6, 7a and 9b) of the SARS-CoV were prepared and used for screening and monitoring their specific IgG antibodies in SARS patient sera by protein microarray. Antibodies to proteins S, 3a, N and 9b were detected in the sera from convalescent-phase SARS patients, whereas those to proteins E, M, 3b, 6 and 7a were undetected. In the detectable specific antibodies, anti-S and anti-N were dominant and could persist in the sera of SARS patients until week 30. Among the rabbit antisera to recombinant proteins S3, N, 3a and 9b, only anti-S3 serum showed significant neutralizing activity to the SARS-CoV infection in Vero E6 cells. The results suggest (1) that anti-S and anti-N antibodies are diagnostic markers and in particular that S3 is immunogenic and therefore is a good candidate as a subunit vaccine antigen; and (2) that, from a virus structure viewpoint, the presence in some human sera of antibodies reacting with two recombinant polypeptides, 3a and 9b, supports the hypothesis that they are synthesized during the virus cycle.
has issue date	2005-04-13(xsd:dateTime)
bibo:doi	10.1016/j.micinf.2005.02.006
bibo:pmid	15878679
has license	no-cc
sha1sum (hex)	d4f9d334eb5ffbefbef6c90a23f7a243fa89065c
schema:url	https://doi.org/10.1016/j.micinf.2005.02.006
resource representing a document's title	Antibody responses to individual proteins of SARS coronavirus and their neutralization activities
has PubMed Central identifier	PMC7110836
has PubMed identifier	15878679
schema:publication	Microbes Infect
resource representing a document's body	covid:d4f9d334eb5ffbefbef6c90a23f7a243fa89065c#body_text
is schema:about of	named entity 'RESPONSES' named entity 'monitoring' named entity 'antibodies' named entity 'viewpoint' named entity 'NOVEL CORONAVIRUS' named entity '28S' named entity 'VIEWPOINT' named entity 'SUBUNIT VACCINE' named entity 'IDENTIFIED' named entity 'IGG' named entity 'DIAGNOSTIC' named entity 'USED' named entity 'CELLS' named entity 'WEEK' named entity 'RESULTS' named entity 'POLYPEPTIDES' named entity 'PROTEINS' named entity 'PRESENCE' named entity 'GOOD' named entity 'STRUCTURAL PROTEINS' named entity 'DIAGNOSTIC MARKERS' named entity 'ACTIVITY' named entity 'TOOLS' named entity 'RECOMBINANT PROTEINS' named entity 'DEVELOPMENT' named entity 'SIGNIFICANT' named entity 'SARS CORONAVIRUS' named entity 'CRITICAL' named entity 'SARS-COV' named entity 'NEUTRALIZATION ' named entity 'SCREENING' named entity 'PHASE' named entity 'ANTIBODIES' named entity 'CYCLE' named entity 'PATIENT' named entity 'MONITORING' named entity 'ANTISERA' named entity 'IMMUNOGENIC' named entity 'PARTICULAR' named entity 'PATIENTS' named entity 'VIRUS' named entity 'STUDY' named entity '282' named entity 'INDIVIDUAL' named entity 'HYPOTHESIS' named entity 'CONVALESCENT' named entity 'SERA' named entity 'DETECTABLE' named entity 'DETECTED' named entity 'SERUM' named entity 'PROFILE' named entity 'CORONAVIRUS' named entity 'IS A' named entity 'THEIR' named entity 'CANDIDATE' named entity 'SUGGEST' named entity 'RABBIT' named entity 'THEIR'

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