About: Mechanisms of viral mutation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mechanisms of viral mutation
Creator	Domingo-Calap, Pilar Sanjuán, Rafael
Source	Medline; PMC
abstract	The remarkable capacity of some viruses to adapt to new hosts and environments is highly dependent on their ability to generate de novo diversity in a short period of time. Rates of spontaneous mutation vary amply among viruses. RNA viruses mutate faster than DNA viruses, single-stranded viruses mutate faster than double-strand virus, and genome size appears to correlate negatively with mutation rate. Viral mutation rates are modulated at different levels, including polymerase fidelity, sequence context, template secondary structure, cellular microenvironment, replication mechanisms, proofreading, and access to post-replicative repair. Additionally, massive numbers of mutations can be introduced by some virus-encoded diversity-generating elements, as well as by host-encoded cytidine/adenine deaminases. Our current knowledge of viral mutation rates indicates that viral genetic diversity is determined by multiple virus- and host-dependent processes, and that viral mutation rates can evolve in response to specific selective pressures.
has issue date	2016-07-08(xsd:dateTime)
bibo:doi	10.1007/s00018-016-2299-6
bibo:pmid	27392606
has license	cc-by
sha1sum (hex)	d51a55b2f7c2277e6435f0ecf13569863cc3adf3
schema:url	https://doi.org/10.1007/s00018-016-2299-6
resource representing a document's title	Mechanisms of viral mutation
has PubMed Central identifier	PMC5075021
has PubMed identifier	27392606
schema:publication	Cell Mol Life Sci
resource representing a document's body	covid:d51a55b2f7c2277e6435f0ecf13569863cc3adf3#body_text
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