About: Intracellular complement − the complosome − in immune cell regulation

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Intracellular complement − the complosome − in immune cell regulation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Intracellular complement − the complosome − in immune cell regulation
Creator	Arbore, Giuseppina Kemper, Claudia Kolev, Martin
Source	Elsevier; Medline; PMC
abstract	Abstract The complement system was defined over a century ago based on its ability to “complement” the antibody-mediated and cell-mediated immune responses against pathogens. Today our understanding of this ancient part of innate immunity has changed substantially and we know now that complement plays an undisputed pivotal role in the regulation of both innate and adaptive immunity. The complement system consists of over 50 blood-circulating, cell-surface expressed and intracellular proteins. It is key in the recognition and elimination of invading pathogens, also in the removal of self-derived danger such as apoptotic cells, and it supports innate immune responses and the initiation of the general inflammatory reactions. The long prevailing classic view of complement was that of a serum-operative danger sensor and first line of defence system, however, recent experimental and clinical evidences have demonstrated that “local” tissue and surprisingly intracellular complement (the complosome) activation impacts on normal cell physiology. This review will focus on novel aspects of intracellular complement activation and its unexpected roles in basic cell processes such as metabolism. We also discuss what the existence of the complosome potentially means for how the host handles intracellular pathogens such as viruses.
has issue date	2017-09-30(xsd:dateTime)
bibo:doi	10.1016/j.molimm.2017.05.012
bibo:pmid	28601357
has license	els-covid
sha1sum (hex)	d5772ae858256cb8d44805aff6e26800c6868eb4
schema:url	https://doi.org/10.1016/j.molimm.2017.05.012
resource representing a document's title	Intracellular complement − the complosome − in immune cell regulation
has PubMed Central identifier	PMC7112704
has PubMed identifier	28601357
schema:publication	Molecular Immunology
resource representing a document's body	covid:d5772ae858256cb8d44805aff6e26800c6868eb4#body_text
is schema:about of	named entity 'removal' named entity 'existence' named entity 'complement system' named entity 'key' named entity 'complement' named entity 'immunity' named entity 'supports' named entity 'host' named entity 'DERIVED' named entity 'TODAY' named entity 'ACTIVATION' named entity 'CELLS' named entity 'IMPACTS' named entity 'CHANGED' named entity 'MEANS' named entity 'INTRACELLULAR' named entity 'ELIMINATION' named entity 'CELL PROCESSES' named entity 'PATHOGENS' named entity 'PLAYS' named entity 'DISCUSS' named entity 'DEMONSTRATED' named entity 'OUR' named entity 'NOVEL' named entity 'ADAPTIVE IMMUNITY' named entity 'CENTURY' named entity 'ITS' named entity 'UNDERSTANDING' named entity 'SURFACE' named entity 'REGULATION' named entity 'HOW' named entity 'REVIEW' named entity 'TISSUE' named entity 'BASIC' named entity 'METABOLISM' named entity 'GENERAL' named entity 'KEY' named entity 'EXPERIMENTAL' named entity 'COMPLEMENT ACTIVATION' named entity 'HOST' named entity 'INFLAMMATORY REACTIONS' named entity 'VIEW' named entity 'INITIATION' named entity 'EXPRESSED' named entity 'VIRUSES' named entity 'REMOVAL' named entity 'HAVE' named entity 'COMPLEMENT SYSTEM' named entity 'OPERATIVE' named entity 'BASED' named entity 'PROTEINS' named entity 'CLASSIC' named entity 'LINE' named entity 'DANGER' named entity 'ROLE' named entity 'PART OF' named entity 'LONG' named entity 'FOCUS' named entity 'SENSOR' named entity 'CELL' named entity 'SYSTEM' named entity 'AGO' named entity 'IMMUNE RESPONSES' named entity 'NORMAL CELL' named entity 'CLINICAL' named entity 'CELL PHYSIOLOGY' named entity 'INNATE IMMUNITY' named entity 'SERUM' named entity 'INTRACELLULAR PATHOGENS' named entity 'SELF' named entity 'MEDIATED' named entity 'RECOGNITION' named entity 'RECENT' named entity 'ANCIENT' named entity 'DEFINED' named entity 'ROLES' named entity 'UNEXPECTED' named entity 'COMPLEMENT' named entity 'APOPTOTIC'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software