About: Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China
Creator	Shen, Qian Xu, Xia Yu, Mu-Qing Liu, Jian-Yu Qu, Yi-Qing Wang, Lian-Zhong Yan, Rong-Di Zhang, Meng-Yu
Source	Medline; PMC
abstract	Background and aim: The outbreak of coronavirus disease 2019 (COVID-19) is quickly turning into a pandemic. We aimed to further clarify the clinical characteristics and the relationship between these features and disease severity. Methods: In this retrospective single-center study, demographic, clinical and laboratory data were collected and analyzed among moderate, severe and critically ill group patients. Results: 88 hospitalization patients confirmed COVID-19 were enrolled in this study. The average age of the patients was 57.11 years (SD, ±15.39). Of these 88 patients, the median body mass index (BMI) was 24.03 (IQR, 21.64-26.61; range 15.05-32.39), the median duration from disease onset to hospital admission were 11 days (IQR, 6.50-14.50). 46.59% patients had one or more comorbidities, with hypertension being the most common (26.14%), followed by diabetes mellitus (12.50%) and coronary atherosclerotic heart disease (CAD) (7.95%). Common symptoms at onset of disease were fever (71.59%), cough (59.09%), dyspnea (38.64%) and fatigue (29.55%). 88 patients were divided into moderate (47 [53.41%]), severe (32 [36.36%]) and critically ill (9 [10.23%]) groups. Compared with severe and moderate patients, lymphocytopenia occurred in 85.71% critically ill patients, and serum IL-2R, IL-6, IL-8, TNF-α, LDH, and cTnI were also increased in 71.42%, 83.33%, 57.14%, 71.43%, 100% and 42.86% in critically ill patients. Through our analysis, the age, comorbidities, lymphocyte count, eosinophil count, ferritin, CRP, LDH, PT and inflammatory cytokines were statistically significant along with the disease severity. Conclusion: We found some clinical characteristic and inflammatory cytokines could reveal the severity of COVID-19 during the outbreak phage. Our research could assist the clinicians recognize severe and critically ill patients timely and focus on the expectant treatment for each patient.
has issue date	2020-07-25(xsd:dateTime)
bibo:doi	10.7150/ijms.47935
bibo:pmid	32788884
has license	cc-by
sha1sum (hex)	d578cb54214d2aeea515426ec138cb9f1564f3a8
schema:url	https://doi.org/10.7150/ijms.47935
resource representing a document's title	Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China
has PubMed Central identifier	PMC7415392
has PubMed identifier	32788884
schema:publication	Int J Med Sci
resource representing a document's body	covid:d578cb54214d2aeea515426ec138cb9f1564f3a8#body_text
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