About: Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

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About: Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
Creator	Thiel, Volker Ziebuhr, John Ludewig, Burkhard Maier, Reinhard Cervantes-Barragan, Luisa Züst, Roland Habjan, Matthias Barchet, Winfried Siddell, Stuart Diamond, Michael Neuman, Benjamin Baker, Susan Szretter, Kristy
source	Medline; PMC
abstract	The 5′ cap structures of higher eukaryote mRNAs have ribose 2′-O-methylation. Likewise, many viruses that replicate in the cytoplasm of eukaryotes have evolved 2′-O-methyltransferases to autonomously modify their mRNAs. However, a defined biological role for 2′-O-methylation of mRNA remains elusive. Here we show that 2′-O-methylation of viral mRNA was critically involved in subverting the induction of type I interferon. We demonstrate that human and mouse coronavirus mutants lacking 2′-O-methyltransferase activity induced higher expression of type I interferon and were highly sensitive to type I interferon. Notably, the induction of type I interferon by viruses deficient in 2′-O-methyltransferase was dependent on the cytoplasmic RNA sensor Mda5. This link between Mda5-mediated sensing of viral RNA and 2′-O-methylation of mRNA suggests that RNA modifications such as 2′-O-methylation provide a molecular signature for the discrimination of self and non-self mRNA.
has issue date	2011-01-09(xsd:dateTime)
bibo:doi	10.1038/ni.1979
bibo:pmid	21217758
has license	green-oa
sha1sum (hex)	d5856d08e6923ed5366f12e5684243cf1ff98b9f
schema:url	https://doi.org/10.1038/ni.1979
resource representing a document's title	Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
has PubMed Central identifier	PMC3182538
has PubMed identifier	21217758
schema:publication	Nature Immunology
resource representing a document's body	covid:d5856d08e6923ed5366f12e5684243cf1ff98b9f#body_text
is schema:about of	named entity 'SUPPLEMENTARY INFORMATION' named entity '2'-O-methylation' named entity 'MDA5' named entity 'O-METHYLATION' named entity 'RIBOSE' named entity 'DEPENDENT' named entity 'MOLECULAR SIGNATURE' named entity 'SELF' named entity 'MRNA' named entity 'NON-SELF' named entity 'PROVIDES' named entity 'Ribose' named entity 'Statistical analysis' named entity '0.01' named entity 'Student's t-test' named entity 'MDA5' named entity 'mRNA' named entity '2'-O-methylation' named entity 'non-self' named entity 'non-self' named entity 'dependent' named entity 'mRNA' named entity 'Ribose' named entity 'molecular' named entity 'MDA5'
is part of of	Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5 covid:d5856d08e6923ed5366f12e5684243cf1ff98b9f#body_text The 5′ cap structures of higher eukaryote mRNAs have ribose 2′-O-methylation. Likewise, many viruses that replicate in the cytoplasm of eukaryotes have evolved 2′-O-methyltransferases to autonomously modify their mRNAs. However, a defined biological role for 2′-O-methylation of mRNA remains elusive. Here we show that 2′-O-methylation of viral mRNA was critically involved in subverting the induction of type I interferon. We demonstrate that human and mouse coronavirus mutants lacking 2′-O-methyltransferase activity induced higher expression of type I interferon and were highly sensitive to type I interferon. Notably, the induction of type I interferon by viruses deficient in 2′-O-methyltransferase was dependent on the cytoplasmic RNA sensor Mda5. This link between Mda5-mediated sensing of viral RNA and 2′-O-methylation of mRNA suggests that RNA modifications such as 2′-O-methylation provide a molecular signature for the discrimination of self and non-self mRNA.

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