About: BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment
Creator	Li, Yang Curtis, Nigel Joosten, Leo Netea, Mihai Schultze, Joachim Van Crevel, Reinout Benn, Christine Blok, Bas Bremmers, M Chan, Joyce Charlotte, L Cirovic, Branko De Bree, J Groh, Laszlo H€, Kristian Klee, Kathrin Koeken, Valerie Oosting, Marije Picelli, Simone Schulte-Schrepping, Jonas Schlitzer, Andreas Van Der Velden, Walter Van Ingen, Jakko
Source	Elsevier; Medline; PMC
abstract	Induction of trained immunity by Bacille-Calmette-Guérin (BCG) vaccination mediates beneficial heterologous effects, but the mechanisms underlying its persistence and magnitude remain elusive. In this study, we show that BCG vaccination in healthy human volunteers induces a persistent transcriptional program connected to myeloid cell development and function within the hematopoietic stem and progenitor cell (HSPC) compartment in the bone marrow. We identify hepatic nuclear factor (HNF) family members 1a and b as crucial regulators of this transcriptional shift. These findings are corroborated by higher granulocyte numbers in BCG-vaccinated infants, HNF1 SNP variants that correlate with trained immunity, and elevated serum concentrations of the HNF1 target alpha-1 antitrypsin. Additionally, transcriptomic HSPC remodeling was epigenetically conveyed to peripheral CD14(+) monocytes, displaying an activated transcriptional signature three months after BCG vaccination. Taken together, transcriptomic, epigenomic, and functional reprogramming of HSPCs and peripheral monocytes is a hallmark of BCG-induced trained immunity in humans.
has issue date	2020-06-15(xsd:dateTime)
bibo:doi	10.1016/j.chom.2020.05.014
bibo:pmid	32544459
has license	no-cc
sha1sum (hex)	d585dbd43e1d1b6e878f4446f9d8cf3d4ba40db1
schema:url	https://doi.org/10.1016/j.chom.2020.05.014
resource representing a document's title	BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment
has PubMed Central identifier	PMC7295478
has PubMed identifier	32544459
schema:publication	Cell Host Microbe
resource representing a document's body	covid:d585dbd43e1d1b6e878f4446f9d8cf3d4ba40db1#body_text
is schema:about of	named entity 'Progenitor' named entity 'PERIPHERAL' named entity 'ABSTRACT' named entity 'IMMUNE' named entity 'REGULATORS' named entity 'BCG vaccination' named entity 'induces' named entity 'Compartment' named entity 'Hematopoietic' named entity 'BCG Vaccination' named entity 'innate immune' named entity 'monocytes' named entity 'nuclear factors' named entity 'CD14' named entity 'epigenetic' named entity 'Hepatic' named entity 'vaccination' named entity 'HSPCs' named entity 'HSPCs' named entity 'homeobox' named entity 'TRANSFAC' named entity 'GFI1' named entity 'HNF1A' named entity 'transcriptome' named entity 'HIV positive' named entity 'D90' named entity 'newborn infants' named entity 'Australia' named entity 'vaccination' named entity 'physiological relevance' named entity 'BCG' named entity 'LGALS3' named entity 'placebo' named entity 'vaccination' named entity 'ligand' named entity 'BCG vaccine' named entity 'Infection' named entity 'myeloid cell' named entity 'mycobacterial' named entity 'CD14' named entity 'HNF1A' named entity 'phenotype' named entity 'CCL23' named entity 'BCG vaccination' named entity 'BCG vaccination' named entity 'histone modifications' named entity 'vaccination' named entity 'intradermal' named entity 'IL6' named entity 'neutrophils' named entity 'locus' named entity 'ATAC' named entity 'randomised controlled trial' named entity 'murine models' named entity 'transcriptomic' named entity 'PBMC' named entity 'pathogens' named entity 'receptor' named entity 'macrophages'

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