About: T-cell immunosenescence: lessons learned from mouse models of aging

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	T-cell immunosenescence: lessons learned from mouse models of aging
Creator	Haynes, Laura Blackman, Marcia Maue, Alexander Swain, Susan Woodland, David Yager, Eric
source	Elsevier; Medline; PMC
abstract	It is well established that increasing age is associated with a decreased capacity of the immune system to mediate effective immune responses to vaccination and invading pathogens. Because of the inherent limitations of conducting experiments in humans, much of what we have learned is owed to the utility of experimental mouse models of aging. Recent studies performed in the mouse have demonstrated mechanisms responsible for age-related declines in the function of CD4(+) and CD8(+) cells. This review describes key findings regarding age-related defects in T-cell function and discusses the impact these defects have on vaccine efficacy and immunity.
has issue date	2009-07-01(xsd:dateTime)
bibo:doi	10.1016/j.it.2009.04.007
bibo:pmid	19541537
has license	green-oa
sha1sum (hex)	d5ad926afb0860117c4bc646191a47a3d6b23dbc
schema:url	https://doi.org/10.1016/j.it.2009.04.007
resource representing a document's title	T-cell immunosenescence: lessons learned from mouse models of aging
has PubMed Central identifier	PMC3755270
has PubMed identifier	19541537
schema:publication	Trends in Immunology
resource representing a document's body	covid:d5ad926afb0860117c4bc646191a47a3d6b23dbc#body_text
is schema:about of	named entity 'function' named entity 'PATHOGENS' named entity 'AGE' named entity 'VACCINATION' named entity 'MOUSE' named entity 'LIMITATIONS' named entity 'CAPACITY' named entity 'EXPERIMENTS' named entity 'MOUSE MODELS' named entity 'THESE' named entity 'IMMUNITY' named entity 'MECHANISMS' named entity 'RELATED' named entity 'AGING' named entity 'CD8' named entity 'RESPONSIBLE' named entity 'CELL FUNCTION' named entity 'AGING' named entity 'IMMUNE RESPONSES' named entity 'KEY' named entity 'FUNCTION' named entity 'HAVE' named entity 'DEMONSTRATED' named entity 'VACCINE EFFICACY' named entity 'LEARNED' named entity 'IMMUNOSENESCENCE' named entity 'T-CELL' named entity 'FINDINGS' named entity 'WHAT' named entity 'ASSOCIATED WITH' named entity 'MEDIATE' named entity 'IMPACT' named entity 'REVIEW' named entity 'INCREASING' named entity 'LEARNED' named entity 'CD4' named entity 'MOUSE MODELS' named entity 'ESTABLISHED' named entity 'MUCH' named entity 'PERFORMED' named entity 'DECREASED' named entity 'CONDUCTING' named entity 'UTILITY' named entity 'STUDIES' named entity 'RECENT' named entity 'EFFECTIVE' named entity 'T-CELL' named entity 'EXPERIMENTAL' named entity 'HUMANS' named entity 'CELLS' named entity 'IMMUNE SYSTEM' named entity 'CD8' named entity 'cells' named entity 'mouse' named entity 'humans' named entity 'efficacy' named entity 'vaccine efficacy' named entity 'T-cell' named entity 'T-cell' named entity 'defects' named entity 'T-cell' named entity 'CD8' named entity 'immunosenescence' named entity 'Sendai' named entity 'T-cell receptor' named entity 'CD8 +' named entity 'Grb2' named entity 'dramatic effects' named entity 'CD4 +' named entity 'CD8 +' named entity 'B-cell' named entity 'T-cell' named entity 'clonal' named entity 'global population' named entity 'B-cell' named entity 'T-cell'

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