About: Kunjin replicon-based simian immunodeficiency virus gag vaccines

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Kunjin replicon-based simian immunodeficiency virus gag vaccines
Creator	Anraku, Itaru Cara, Andrea Leung, Jason Pijlman, Gorben Rattanasena, Paweena Suhrbier, Andreas Khromykh, Alexander Mokhonov, Vladislav Mokhonova, Ekaterina Schroder, Wayne
source	Elsevier; Medline; PMC
abstract	Abstract An RNA-based, non-cytopathic replicon vector system, based on the flavivirus Kunjin, has shown considerable promise as a new vaccine delivery system. Here we describe the testing in mice of four different SIVmac239 gag vaccines delivered by Kunjin replicon virus-like-particles. The four vaccines encoded the wild type gag gene, an RNA-optimised gag gene, a codon-optimised gag gene and a modified gag-pol gene construct. The vaccines behaved quite differently for induction of effector memory and central memory responses, for mediation of protection, and with respect to insert stability, with the SIV gag-pol vaccine providing the optimal performance. These results illustrate that for an RNA-based vector the RNA sequence of the antigen can have profound and unforeseen consequences on vaccine behaviour.
has issue date	2008-06-19(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2008.04.001
bibo:pmid	18462846
has license	els-covid
sha1sum (hex)	d5e257eb542dd3f05e052663701a22b5d1f10860
schema:url	https://doi.org/10.1016/j.vaccine.2008.04.001
resource representing a document's title	Kunjin replicon-based simian immunodeficiency virus gag vaccines
has PubMed Central identifier	PMC7115363
has PubMed identifier	18462846
schema:publication	Vaccine
resource representing a document's body	covid:d5e257eb542dd3f05e052663701a22b5d1f10860#body_text
is schema:about of	named entity 'These' named entity 'optimal' named entity 'vaccines' covid:arg/d5e257eb542dd3f05e052663701a22b5d1f10860 named entity 'effector' named entity 'gag' named entity 'memory' named entity 'vaccines' named entity 'respect' named entity 'RNA-based' named entity 'modified' named entity 'antigen' named entity 'Kunjin' named entity 'flavivirus' named entity 'antigen' named entity 'vaccine delivery' named entity 'vaccine' named entity 'vaccines' named entity 'vaccine' named entity 'nucleotides' named entity 'Kunjin' named entity 'central memory' named entity 'Kunjin' named entity 'electric shaver' named entity 'SIV' named entity 'HIV vaccine' named entity 'subcloning' named entity 'monoclonal antibody' named entity 'flavivirus' named entity 'SIV' named entity 'primer' named entity 'codon' named entity 'alanine' named entity 'Kunjin' named entity 'gag protein' named entity 'replicon' named entity 'Vero' named entity 'recombinant' named entity 'PCR' named entity 'central memory' named entity 'CD8 T cell' named entity 'flaviviruses' named entity 'wild-type' named entity 'alphavirus' named entity 'Dengue virus' named entity 'replicon' named entity 'Kunjin' named entity 'Gag-pol' named entity 'SIV' named entity 'cell line' named entity 'transfected' named entity 'antibody' named entity 'antigen' named entity 'recombination' named entity 'codon' named entity 'vaccination' named entity 'antibiotic' named entity 'gag gene' named entity 'E22' named entity 'RNA' named entity 'SIV' named entity 'replicon' named entity 'Germany' named entity 'peptide' named entity 'transfect' named entity 'central memory' named entity 'Kunjin' named entity 'VLP' named entity 'EGFP' named entity 'replicon' named entity 'SIV' named entity 'replicon'

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