About: Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model

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About: Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model
Creator	Suzumura, Akio Imai, Kenji Iwase, Akira Kikkawa, Fumitaka Kotani, Tomomi Nagai, Taku Nakano, Tomoko Toyokuni, Shinya Tsuda, Hiroyuki Ushida, Takafumi
Source	PMC
abstract	The aim of the present study was to investigate long-term outcomes of the offspring in a lipopolysaccharide (LPS)-induced maternal immune activation (MIA) model and the effect of maternal molecular hydrogen (H(2)) administration. We have previously demonstrated in the MIA mouse model that maternal administration of H(2) attenuates oxidative damage and neuroinflammation, including induced pro-inflammatory cytokines and microglial activation, in the fetal brain. Short-term memory, sociability and social novelty, and sensorimotor gating were evaluated using the Y-maze, three-chamber, and prepulse inhibition (PPI) tests, respectively, at postnatal 3 or 4 weeks. The number of neurons and oligodendrocytes was also analyzed at postnatal 5 weeks by immunohistochemical analysis. Offspring of the LPS-exposed dams showed deficits in short-term memory and social interaction, following neuronal and oligodendrocytic loss in the amygdala and cortex. Maternal H(2) administration markedly attenuated these LPS-induced abnormalities. Moreover, we evaluated the effect of H(2) on LPS-induced astrocytic activation, both in vivo and in vitro. The number of activated astrocytes with hypertrophic morphology was increased in LPS-exposed offspring, but decreased in the offspring of H(2)-administered dams. In primary cultured astrocytes, LPS-induced pro-inflammatory cytokines were attenuated by H(2) administration. Overall, these findings indicate that maternal H(2) administration exerts neuroprotective effects and ameliorates MIA-induced neurodevelopmental deficits of offspring later in life.
has issue date	2018-06-15(xsd:dateTime)
bibo:doi	10.1038/s41598-018-27626-4
bibo:pmid	29907804
has license	cc-by
sha1sum (hex)	d603d8aa5b328d708683d754f224c1f9d170fc64
schema:url	https://doi.org/10.1038/s41598-018-27626-4
resource representing a document's title	Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model
has PubMed Central identifier	PMC6003913
has PubMed identifier	29907804
schema:publication	Sci Rep
resource representing a document's body	covid:d603d8aa5b328d708683d754f224c1f9d170fc64#body_text
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