About: Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry En Route to the Synthesis of Remdesivir

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry En Route to the Synthesis of Remdesivir Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry En Route to the Synthesis of Remdesivir
Creator	Badalov, Pavel Chtchemelinine, Andrei Gao, Detian Heumann, Lars Stevens, Andrew Vieira, Tiago
source	PMC
abstract	[Image: see text] The implementation of cyanation chemistry at manufacturing scales using batch equipment can be challenging because of the hazardous nature of the reagents employed and the tight control of reaction parameters, including cryogenic temperatures, that help to afford acceptable selectivity and conversion for the desired reaction. Application of continuous flow chemistry offers a means to mitigate the risk associated with handling large amounts of hazardous reagents and to better control the reaction parameters. A case study describing the cyanation of a glycoside using continuous flow chemistry toward the synthesis of the drug candidate remdesivir is presented.
has issue date	2020-05-21(xsd:dateTime)
bibo:doi	10.1021/acs.oprd.0c00172
has license	no-cc
sha1sum (hex)	d60b8a66d1162b5480f9c53c05e9b4b557a46640
schema:url	https://doi.org/10.1021/acs.oprd.0c00172
resource representing a document's title	Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry En Route to the Synthesis of Remdesivir
has PubMed Central identifier	PMC7294886
schema:publication	Org Process Res Dev
resource representing a document's body	covid:d60b8a66d1162b5480f9c53c05e9b4b557a46640#body_text
is schema:about of	named entity 'cryogenic' named entity 'case study' named entity 'remdesivir' covid:arg/d60b8a66d1162b5480f9c53c05e9b4b557a46640 named entity 'continuous' named entity 'cyanation' named entity 'chemistry' named entity 'control' named entity 'continuous flow chemistry' named entity 'reaction' named entity 'lactone' named entity 'coronavirus' named entity 'continuous flow chemistry' named entity 'diaphragm' named entity 'remdesivir' named entity 'DCM' named entity 'cyanation' named entity 'diaphragm' named entity 'DCM' named entity 'coronaviruses' named entity 'cell culture' named entity 'diaphragm' named entity 'continuous flow chemistry' named entity 'Preclinical' named entity 'stainless steel' named entity 'cyano group' named entity 'sodium chloride' named entity 'flow reactor' named entity 'flow rates' named entity 'continuous flow chemistry' named entity 'USAMRIID' named entity 'continuous flow chemistry' named entity 'aqueous' named entity 'Gilead' named entity 'heptane' named entity 'chloride' named entity 'flow chemistry' named entity 'Alberta' named entity 'continuous flow chemistry' named entity '1.10' named entity 'TMSOTf' named entity 'trimethylsilyl cyanide' named entity 'remdesivir' named entity 'flow reactor' named entity 'aqueous' named entity 'TMSOTf' named entity 'Chlorotrimethylsilane' named entity 'outbreak of Ebola virus' named entity 'preclinical' named entity 'TMSOTf' named entity 'remdesivir' named entity 'clinical evaluation' named entity 'heat transfer' named entity 'diastereoselectivity' named entity 'potassium bicarbonate' named entity 'cyanation' named entity 'TMSOTf' named entity 'gilead' named entity 'virus' named entity 'Synthetic Route' named entity 'reagent' named entity 'viral pathogenesis' named entity 'MTBE' named entity 'feed line' named entity 'remdesivir' named entity 'stainless steel' named entity '2-propanol' named entity 'TMSCN' named entity 'MERS-CoV' named entity 'Canada' named entity 'TMSCN' named entity 'trifluoroacetic acid' named entity 'HPLC' named entity 'ethyl acetate' named entity 'solvent' named entity 'reactive intermediates' named entity 'tetrahydrofuran' named entity '99.9%'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software