About: Correlation between immunity from BCG and the morbidity and mortality of COVID-19

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Correlation between immunity from BCG and the morbidity and mortality of COVID-19
Creator	Arambepola, Carukshi Kamburugamuwa, Sohan Samarasekera, Dharmabandhu Wickramasinghe, Dakshitha Wickramasinghe, Nilanka
source	PMC
abstract	BACKGROUND: To investigate the association between parameters indicating immunity from BCG at country level (presence of BCG vaccination policy, BCG coverage, age-specific incidence of tuberculosis (TB)) and the morbidity and mortality of COVID-19. METHODS: Country-specific data for COVID-19 cases and deaths, demographic details, BCG coverage and policy, age-specific TB incidence and income level were obtained. The crude COVID-19 cases and deaths per 100,000 population were calculated and assessed against the parameters indicating immunity from BCG using linear regression analysis. RESULTS: Univariate analysis identified higher income level of a country to be significantly associated with COVID-19 cases (p < 0.0001) and deaths (p < 0.0001) but not with its case fatality rate. The association between COVID-19 and TB was strongest for TB incidence in patients > 65-years (Cases (r(s) = − 0.785,p = 0.0001)) and deaths (r(s) = − 0.647,p = 0.0001). Multivariate analysis identified the higher income level of a country and not having a universal BCG vaccination policy to affect the COVID-19 cases. The deaths were inversely affected by the presence of BCG vaccination policy and coverage; and positively by the TB incidence in patients > 65-years. CONCLUSION: Significant inverse correlations observed between cases and deaths of COVID-19 and BCG related parameters highlights immunity from BCG as a likely explanation for the variation in COVID-19 across countries.
has issue date	2020-08-28(xsd:dateTime)
bibo:doi	10.1186/s40794-020-00117-z
has license	no-cc
sha1sum (hex)	d61e2018617057cf4a6533bc7ed1ef38586825f7
schema:url	https://doi.org/10.1186/s40794-020-00117-z
resource representing a document's title	Correlation between immunity from BCG and the morbidity and mortality of COVID-19
has PubMed Central identifier	PMC7453689
schema:publication	Trop Dis Travel Med Vaccines
resource representing a document's body	covid:d61e2018617057cf4a6533bc7ed1ef38586825f7#body_text
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