About: PTH[1-34] improves the effects of core decompression in early-stage steroid-associated osteonecrosis model by enhancing bone repair and revascularization

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About: PTH[1-34] improves the effects of core decompression in early-stage steroid-associated osteonecrosis model by enhancing bone repair and revascularization Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	PTH[1-34] improves the effects of core decompression in early-stage steroid-associated osteonecrosis model by enhancing bone repair and revascularization
Creator	Hu, Bin Yang, Xiao-Bo Lin, Tiao Shen, Yue Heng, Boon Zhao, Meng, Shen, Wei-Liang Shi, Zhong-Li Yan, Shi-Gui Ye, Zhou, Chen-He Zhu, Han-Xiao
Source	PMC
abstract	Steroid-associated osteonecrosis (SAON) might induce bone collapse and subsequently lead to joint arthroplasty. Core decompression (CD) is regarded as an effective therapy for early-stage SAON, but the prognosis is unsatisfactory due to incomplete bone repair. Parathyroid hormone[1–34] (PTH[1–34]) has demonstrated positive efficacy in promoting bone formation. We therefore evaluated the effects of PTH on improving the effects of CD in Early-Stage SAON. Distal femoral CD was performed two weeks after osteonecrosis induction or vehicle injection, with ten of the ON-induced rabbits being subjected to six-week PTH[1–34] treatment and the others, including ON-induced and non-induced rabbits, being treated with vehicle. MRI confirmed that intermittent PTH administration improved SAON after CD therapy. Micro-CT showed increased bone formation within the tunnel. Bone repair was enhanced with decreased empty osteocyte lacunae and necrosis foci area, resulting in enhanced peak load and stiffness of the tunnel. Additionally, PTH enlarged the mean diameter of vessels in the marrow and increased the number of vessels within the tunnels, as well as elevated the expression of BMP-2, RUNX2, IGF-1, bFGF and VEGF, together with serum OCN and VEGF levels. Therefore, PTH[1–34] enhances the efficacy of CD on osteogenesis and neovascularization, thus promoting bone and blood vessels repair in the SAON model.
has issue date	2017-05-31(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0178781
bibo:pmid	28562696
has license	cc-by
sha1sum (hex)	d63201b4350a82c89280d64cf8a0fcbdffaaf40c
schema:url	https://doi.org/10.1371/journal.pone.0178781
resource representing a document's title	PTH[1-34] improves the effects of core decompression in early-stage steroid-associated osteonecrosis model by enhancing bone repair and revascularization
has PubMed Central identifier	PMC5451136
has PubMed identifier	28562696
schema:publication	PLoS One
resource representing a document's body	covid:d63201b4350a82c89280d64cf8a0fcbdffaaf40c#body_text
is schema:about of	named entity 'MICRO-CT' named entity 'NUMBER OF' named entity 'INDUCTION' named entity 'VESSELS' named entity 'INCLUDING' named entity 'EXPRESSION' named entity 'OCN' named entity 'BONE REPAIR' named entity '2F10' named entity 'CORE DECOMPRESSION' named entity 'RESULTING IN' named entity 'INTERMITTENT' named entity 'PARATHYROID HORMONE' named entity 'ENLARGED' named entity 'MODEL' named entity 'REVASCULARIZATION' named entity 'BFGF' named entity 'WEEK' named entity 'INCREASED BONE FORMATION' named entity 'PTH' named entity 'LEAD' named entity 'RABBITS' named entity 'CITATION' named entity 'IGF-1' named entity 'RUNX2' named entity 'ELEVATED' named entity 'AREA' named entity 'LACUNAE' named entity 'VEGF' named entity 'MODEL' named entity 'STEROID' named entity 'bone' named entity 'decompression' named entity 'repair' named entity 'therapy' named entity 'lead' named entity 'osteonecrosis' named entity 'enhancing' named entity '5B1' named entity 'ENHANCING' named entity 'OSTEONECROSIS' named entity 'ASSOCIATED' named entity 'VEHICLE' named entity 'DECREASED' named entity 'ADMINISTRATION' named entity 'STIFFNESS' named entity 'ZHOU' named entity 'EFFECTS' named entity 'REPAIR' named entity 'SERUM' named entity 'OSTEOCYTE' named entity 'INJECTION' named entity 'UNSATISFACTORY' named entity 'TREATED WITH' named entity 'MRI' named entity 'INCREASED' named entity 'BLOOD VESSELS' named entity 'MARROW' named entity 'TWO WEEKS' named entity 'NEOVASCULARIZATION' named entity 'ASSOCIATED' named entity 'EFFICACY' named entity 'NON-' named entity 'STAGE' named entity 'PTH' covid:arg/d63201b4350a82c89280d64cf8a0fcbdffaaf40c named entity 'STAGE' named entity 'CORE DECOMPRESSION' named entity 'EFFECTS'

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