About: Viral Etiology and the Impact of Codetection in Young Children Presenting With Influenza-Like Illness

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About: Viral Etiology and the Impact of Codetection in Young Children Presenting With Influenza-Like Illness Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral Etiology and the Impact of Codetection in Young Children Presenting With Influenza-Like Illness
Creator	Smith, David Richmond, Peter Levy, Avram Blyth, Christopher De Klerk, Nicholas Effler, Paul Lim, Faye Moore, Hannah Keil, Anthony Conway, Nicholas Tempone, Simone Wake, Zoe
Source	Medline; PMC
abstract	BACKGROUND: Children with acute respiratory tract infection (ARTI) frequently exhibit virus-virus codetection, yet the clinical significance of ARTI remains contentious. Using data from a prospective cohort of children with influenza-like illness, we examined the virology of ARTI and determined the clinical impact of virus-virus codetection. METHODS: Children aged 6 to 59 months who presented to a tertiary pediatric hospital between influenza seasons 2008 and 2012 with fever and acute respiratory symptoms were enrolled, and nasal samples were collected. Respiratory viruses were identified by culture and polymerase chain reaction. We compared demographics, presenting symptoms, and clinical outcomes of children with a single-virus infection and those in whom 2 or more viruses were detected (virus-virus codetection). We used logistic regression models and estimated marginal means to calculate the adjusted odds ratios and probabilities of symptom presentation, prescription of antibiotics, and hospitalization. RESULTS: Of 2356 children, a virus was detected in 1630 (69.2%) of them; rhinovirus (40.8%), influenza (29.5%), and respiratory syncytial virus (26.4%) were detected most commonly. Two or more viruses were detected in 25% of these children. After we adjusted for demographic factors, children with virus-virus codetection had greater odds of presenting with cough (adjusted odds ratio [aOR], 1.9; 95% confidence interval [CI], 1.2–3.1) and rhinorrhea (aOR, 1.8; 95% CI, 1.1–2.9) than those with a single-virus infection, although both symptoms were common. Children with influenza and respiratory syncytial virus combined had the highest probability of hospitalization (55%; 95% CI, 35%–73%), which was significantly greater than for those with influenza infection alone (22%; 95% CI, 16%–29%). CONCLUSIONS: Overall, virus-virus codetection has limited impact on clinical severity among children with influenza-like illness. However, infection with specific pathogen pairs might be associated with more severe outcomes. Routine diagnostics to identify specific viruses should be restricted to common pathogens.
has issue date	2016-07-20(xsd:dateTime)
bibo:doi	10.1093/jpids/piw042
bibo:pmid	27440506
has license	no-cc
sha1sum (hex)	d6488865ab8729b374794e7a9b0bfe575e040766
schema:url	https://doi.org/10.1093/jpids/piw042
resource representing a document's title	Viral Etiology and the Impact of Codetection in Young Children Presenting With Influenza-Like Illness
has PubMed Central identifier	PMC7107488
has PubMed identifier	27440506
schema:publication	J Pediatric Infect Dis Soc
resource representing a document's body	covid:d6488865ab8729b374794e7a9b0bfe575e040766#body_text
is schema:about of	named entity 'VIRAL' named entity 'frequently' named entity 'impact' named entity 'Presenting' named entity 'ETIOLOGY' named entity 'SOCIETY' named entity 'IMPACT' named entity 'PROSPECTIVE COHORT' named entity 'VIRUS' named entity 'BACKGROUND' named entity 'EXAMINED' named entity 'ARTI' named entity 'IMPACT' named entity 'USING' named entity 'CHILDREN' named entity 'VIROLOGY' named entity 'PEDIATRIC INFECTIOUS DISEASES' named entity 'JOURNAL ' covid:arg/d6488865ab8729b374794e7a9b0bfe575e040766 named entity 'INFLUENZA-LIKE ILLNESS' named entity 'ACUTE RESPIRATORY TRACT INFECTION' named entity 'DETERMINED' named entity 'DATA' named entity 'PRESENTING' named entity 'YOUNG CHILDREN' named entity 'INFLUENZA-LIKE ILLNESS' named entity 'CLINICAL' named entity 'CLINICAL SIGNIFICANCE' named entity 'FREQUENTLY' named entity 'EXHIBIT' named entity 'acute' named entity 'virology' named entity 'Etiology' named entity 'Viral' named entity 'Young Children' named entity 'respiratory symptom' named entity 'enteroviruses' named entity 'young children' named entity 'rhinorrhea' named entity 'immunofluorescent' named entity 'Comorbidities' named entity 'pathogenicity' named entity 'respiratory syncytial viruses' named entity 'Infection' named entity 'Millipore' named entity 'virus' named entity 'rash' named entity 'home care' named entity 'virus' named entity 'pathogens' named entity 'influenza' named entity 'A/H3N2' named entity 'cohort study' named entity 'PCR' named entity 'influenza-like illness' named entity 'Western Australia' named entity 'virus' named entity 'day care center' named entity 'Aboriginal status' named entity 'pediatric' named entity 'risk factors' named entity 'pathogen' named entity 'antibiotics' named entity 'virus' named entity 'SPSS' named entity 'pathogens' named entity 'antibiotics' named entity 'cough' named entity '95% CI' named entity 'fever'

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