About: Pre-existing liver disease is associated with poor outcome in patients with SARS CoV2 infection; The APCOLIS Study (APASL COVID-19 Liver Injury Spectrum Study)

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About: Pre-existing liver disease is associated with poor outcome in patients with SARS CoV2 infection; The APCOLIS Study (APASL COVID-19 Liver Injury Spectrum Study) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pre-existing liver disease is associated with poor outcome in patients with SARS CoV2 infection; The APCOLIS Study (APASL COVID-19 Liver Injury Spectrum Study)
Creator	Zheng, Ming-Hua Jafri, Wasim Ji, Dong Park, Gi Mahtab, Al Sarin, Shiv Lau, George Alam, Shahinul Choudhury, · Cua, Ian Gani, Rino Jeong, · Jun, · Lau, · Lovkesh, · Qi, · Shukla, · Soin, · Abd-Elsalam, Sherief Chang, · Putcharoen, Opass Ahn, Hoon Alonzo, Romar Badamnachin Batsukh, · Chuang, · Wan-Long Dara, Pal Diana, · Eslam, · Esmail, Saber Garg, K Hery, · Hitendra, · Hwang, · Kaewdech, · Kemal Kalista, · Khalaf, Mai Lin, · Chun-Yu Loho, Imelda Mamun, · Manoj, · Oidov Baatarkhuu, · Park, Sooyoung Payawal, A Piratvisuth, Teerha Purnomo, Djagat Rathi, · Salisa, · Sang, · Sharma, K Soeksiam Tan, · Sombat Treeprasertsuk, · Soo, Ing Suh, Ill Tanwandee, Tawesak Tserendorj Chinbayar, · Uzziel, · Vijay, · Yeo, Dong Yokosuka, ·
Source	Medline; PMC
abstract	BACKGROUND AND AIMS: COVID-19 is a dominant pulmonary disease, with multisystem involvement, depending upon comorbidities. Its profile in patients with pre-existing chronic liver disease (CLD) is largely unknown. We studied the liver injury patterns of SARS-Cov-2 in CLD patients, with or without cirrhosis. METHODS: Data was collected from 13 Asian countries on patients with CLD, known or newly diagnosed, with confirmed COVID-19. RESULTS: Altogether, 228 patients [185 CLD without cirrhosis and 43 with cirrhosis] were enrolled, with comorbidities in nearly 80%. Metabolism associated fatty liver disease (113, 61%) and viral etiology (26, 60%) were common. In CLD without cirrhosis, diabetes [57.7% vs 39.7%, OR = 2.1 (1.1–3.7), p = 0.01] and in cirrhotics, obesity, [64.3% vs. 17.2%, OR = 8.1 (1.9–38.8), p = 0.002] predisposed more to liver injury than those without these. Forty three percent of CLD without cirrhosis presented as acute liver injury and 20% cirrhotics presented with either acute-on-chronic liver failure [5 (11.6%)] or acute decompensation [4 (9%)]. Liver related complications increased (p < 0.05) with stage of liver disease; a Child-Turcotte Pugh score of 9 or more at presentation predicted high mortality [AUROC 0.94, HR = 19.2 (95 CI 2.3–163.3), p < 0.001, sensitivity 85.7% and specificity 94.4%). In decompensated cirrhotics, the liver injury was progressive in 57% patients, with 43% mortality. Rising bilirubin and AST/ALT ratio predicted mortality among cirrhosis patients. CONCLUSIONS: SARS-Cov-2 infection causes significant liver injury in CLD patients, decompensating one fifth of cirrhosis, and worsening the clinical status of the already decompensated. The CLD patients with diabetes and obesity are more vulnerable and should be closely monitored. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12072-020-10072-8) contains supplementary material, which is available to authorized users.
has issue date	2020-07-04(xsd:dateTime)
bibo:doi	10.1007/s12072-020-10072-8
bibo:pmid	32623632
has license	no-cc
sha1sum (hex)	d658e8b2fd990c8489dec760fcbf23d46a5e29b6
schema:url	https://doi.org/10.1007/s12072-020-10072-8
resource representing a document's title	Pre-existing liver disease is associated with poor outcome in patients with SARS CoV2 infection; The APCOLIS Study (APASL COVID-19 Liver Injury Spectrum Study)
has PubMed Central identifier	PMC7334898
has PubMed identifier	32623632
schema:publication	Hepatol Int
resource representing a document's body	covid:d658e8b2fd990c8489dec760fcbf23d46a5e29b6#body_text
is schema:about of	named entity 'pulmonary disease' named entity 'presentation' named entity 'studied' named entity 'chronic liver disease' named entity 'patients' named entity 'Pugh' named entity 'predisposed' named entity 'Metabolism' named entity 'SARS-Cov-2' named entity 'SARS-Cov-2' named entity 'mortality' named entity 'Asian' named entity 'presented' named entity 'Data' named entity 'COVID-19' named entity 'RATIO' named entity 'RELATED' named entity 'OF LIVER DISEASE' named entity '5B4' named entity '8.1' named entity '0.05' named entity 'PERCENT' named entity 'CHRONIC LIVER DISEASE'

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