About: Genetic Evidence of Middle East Respiratory Syndrome Coronavirus (MERS-Cov) and Widespread Seroprevalence among Camels in Kenya

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About: Genetic Evidence of Middle East Respiratory Syndrome Coronavirus (MERS-Cov) and Widespread Seroprevalence among Camels in Kenya Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genetic Evidence of Middle East Respiratory Syndrome Coronavirus (MERS-Cov) and Widespread Seroprevalence among Camels in Kenya
Creator	Chen, Jing Zhu, Yan Zhang, Wei Luo, Yun Yang, Xing-Lou Obanda, Vincent Ommeh, Sheila Waruhiu, Cecilia Yan, Bing Zhang, Huajun Li, Shan Gakuya, Francis Lichoti, Jacqueline Masika, Moses Mungube, Erick Odendo, Vincent Anderson, Danielle Agwanda, • Desterio Ouma, • Ge, Yi Hu, • Kisa-Juma Ngeiywa, • Li, • Lin-Fa, • Peng, • Shi, • Zheng-Li Wang, Xing-, • Zohaib, •
Source	Medline; PMC
abstract	We describe the first genome isolation of Middle East respiratory syndrome coronavirus (MERS-CoV) in Kenya. This fatal zoonotic pathogen was first described in the Kingdom of Saudi Arabia in 2012. Epidemiological and molecular evidence revealed zoonotic transmission from camels to humans and between humans. Currently, MERS-CoV is classified by the WHO as having high pandemic potential requiring greater surveillance. Previous studies of MERS-CoV in Kenya mainly focused on site-specific and archived camel and human serum samples for antibodies. We conducted active nationwide cross-sectional surveillance of camels and humans in Kenya, targeting both nasal swabs and plasma samples from 1,163 camels and 486 humans collected from January 2016 to June 2018. A total of 792 camel plasma samples were positive by ELISA. Seroprevalence increased with age, and the highest prevalence was observed in adult camels (82.37%, 95% confidence interval (CI) 79.50–84.91). More female camels were significantly seropositive (74.28%, 95% CI 71.14–77.19) than male camels (P < 0.001) (53.74%, 95% CI 48.48–58.90). Only 11 camel nasal swabs were positive for MERS-CoV by reverse transcription-quantitative PCR. Phylogenetic analysis of whole genome sequences showed that Kenyan MERS-CoV clustered within sub-clade C2, which is associated with the African clade, but did not contain signature deletions of orf4b in African viruses. None of the human plasma screened contained neutralizing antibodies against MERS-CoV. This study confirms the geographically widespread occurrence of MERS-CoV in Kenyan camels. Further one-health surveillance approaches in camels, wildlife, and human populations are needed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12250-018-0076-4) contains supplementary material, which is available to authorized users.
has issue date	2018-12-20(xsd:dateTime)
bibo:doi	10.1007/s12250-018-0076-4
bibo:pmid	30570714
has license	cc-by
sha1sum (hex)	d6750dff2734f993de45ffc3020428036b15ac21
schema:url	https://doi.org/10.1007/s12250-018-0076-4
resource representing a document's title	Genetic Evidence of Middle East Respiratory Syndrome Coronavirus (MERS-Cov) and Widespread Seroprevalence among Camels in Kenya
has PubMed Central identifier	PMC6335226
has PubMed identifier	30570714
schema:publication	Virol Sin
resource representing a document's body	covid:d6750dff2734f993de45ffc3020428036b15ac21#body_text
is schema:about of	named entity 'contained' named entity 'human populations' named entity 'camels' named entity 'plasma' named entity 'pathogen' named entity 'BUT' named entity 'HUMAN PLASMA' covid:arg/d6750dff2734f993de45ffc3020428036b15ac21 named entity 'REVEALED' named entity 'GREATER' named entity '90%' named entity 'CONFIRMS' named entity 'STUDIES' named entity 'GENOME' named entity '0.001' named entity 'JANUARY' named entity 'ZOONOTIC' named entity 'HUMANS' named entity 'ELISA' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'KENYA' named entity 'FOCUSED' named entity 'COLLECTED' named entity 'CLASSIFIED' named entity 'SAMPLES' named entity 'STUDY' named entity 'WILDLIFE' named entity 'CAMEL' named entity 'DID' named entity '792' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'TOTAL' named entity 'PLASMA' named entity 'HUMAN' named entity 'ON SITE' named entity 'HIGH' named entity 'DESCRIBED' named entity 'PREVALENCE' named entity 'WIDESPREAD' named entity 'EVIDENCE OF' named entity 'SEROPREVALENCE' named entity 'KENYA' named entity 'REVERSE TRANSCRIPTION' named entity 'SPECIFIC' named entity 'POTENTIAL' named entity 'POPULATIONS' named entity 'SIGNATURE' named entity 'ARCHIVED' named entity 'AGE' named entity 'MALE' named entity 'EVIDENCE' named entity 'KINGDOM OF SAUDI ARABIA' named entity 'ASSOCIATED WITH'

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