About: Bortezomib-Induced Diffuse Alveolar Hemorrhage in a Patient with Plasma Cell Leukemia

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bortezomib-Induced Diffuse Alveolar Hemorrhage in a Patient with Plasma Cell Leukemia
Creator	Peters, Gregory Wirth, Ingrid Leukemia, Ingrid Wirth,
Source	Elsevier; Medline; PMC
abstract	Bortezomib, a chemotherapeutic agent used in the treatment of hematologic malignancies, has been associated with multiple forms of lung injury including diffuse alveolar hemorrhage (DAH). We present the first reported case of bortezomib-induced DAH in a patient with plasma cell leukemia. This 59-year-old female developed hemoptysis, severe cough, and diffuse bilateral ground glass opacities on CT scan of the chest after receiving one dose of bortezomib, with DAH subsequently confirmed on bronchoalveolar lavage. Unlike most previously reported cases, she did not develop respiratory failure requiring high dose corticosteroids, and in fact did not require any supplemental oxygen. We also provide a comparative summary of all reports of bortezomib-induced DAH in the literature to date. This case provides additional insight into the spectrum of disease severity observed in DAH secondary to bortezomib therapy.
has issue date	2020-07-21(xsd:dateTime)
bibo:doi	10.1016/j.rmcr.2020.101169
bibo:pmid	32754424
has license	no-cc
sha1sum (hex)	d6d1eec1a99924470e9b60da7e5f932f0b9c0240
schema:url	https://doi.org/10.1016/j.rmcr.2020.101169
resource representing a document's title	Bortezomib-Induced Diffuse Alveolar Hemorrhage in a Patient with Plasma Cell Leukemia
has PubMed Central identifier	PMC7371580
has PubMed identifier	32754424
schema:publication	Respir Med Case Rep
resource representing a document's body	covid:d6d1eec1a99924470e9b60da7e5f932f0b9c0240#body_text
is schema:about of	named entity 'case' named entity 'ground glass opacities' named entity 'DAH' named entity 'provide' named entity 'DAH' named entity 'diffuse alveolar hemorrhage' named entity 'female' named entity 'Alveolar' named entity 'Cell' named entity 'Patient' named entity 'INCLUDING' named entity 'SUMMARY' named entity 'AGENT USED' named entity 'RESPIRATORY FAILURE' named entity 'develop' named entity 'oxygen' named entity 'bilateral' named entity 'cases' named entity 'DAH' named entity 'hematologic malignancies' named entity 'developed' named entity 'receiving' named entity 'lung' named entity 'hemoptysis' named entity 'cough' named entity 'Plasma Cell' named entity 'Plasma Cell Leukemia' named entity 'CRP' named entity 'antiproliferative effects' named entity 'glomerular basement membrane' named entity 'DAH' named entity 'DAH' named entity 'oxygen saturation' named entity 'cytoplasmic' named entity 'protein' named entity 'DAH' named entity 'DAH' named entity 'ground glass opacities' named entity 'bortezomib' named entity 'hemorrhage' named entity 'hypoxemic' named entity 'inflammation' named entity 'steroids' named entity 'malignant cells' named entity 'diffuse alveolar hemorrhage' named entity 'DAD' named entity 'hemoptysis' named entity 'pleural effusions' named entity 'CT scan' named entity 'lupus anticoagulant' named entity 'NFκB' named entity 'DAH' named entity 'chills' named entity 'Japan' named entity 'smoke tobacco' named entity 'pulmonary complications' named entity 'interstitial pneumonia' named entity 'NFκB' named entity 'afebrile' named entity 'BILD' named entity 'alveolar' named entity 'plasma cell leukemia' named entity 'bronchoalveolar lavage' named entity 'DAH' named entity 'cough' named entity 'BILD' named entity 'chemotherapeutic regimen' named entity 'COVID-19' named entity 'bortezomib' named entity 'DAH' named entity 'BILD' named entity 'oxygen saturation' named entity 'hemorrhage' named entity 'hypoxia' named entity 'bortezomib' named entity 'cytopenias' named entity 'adverse effects' named entity 'dexamethasone'

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