About: Bovine Respiratory Syncytial Virus Enhances the Adherence of Pasteurella multocida to Bovine Lower Respiratory Tract Epithelial Cells by Upregulating the Platelet-Activating Factor Receptor

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About: Bovine Respiratory Syncytial Virus Enhances the Adherence of Pasteurella multocida to Bovine Lower Respiratory Tract Epithelial Cells by Upregulating the Platelet-Activating Factor Receptor Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bovine Respiratory Syncytial Virus Enhances the Adherence of Pasteurella multocida to Bovine Lower Respiratory Tract Epithelial Cells by Upregulating the Platelet-Activating Factor Receptor
Creator	Okabayashi, Tamaki Kubo, Meiko Mekata, Hirohisa Adachi, Akio Saito, Akatsuki Mcgill, Jodi Sudaryatma, Putu Fahkrajang, Watcharapong Mazimpaka, Eugene Saad, M
Source	Medline; PMC
abstract	Coinfection by bovine respiratory syncytial virus (BRSV) and Pasteurella multocida (PM) frequently has been observed in cattle that develop severe pneumonia. We recently reported that BRSV infection significantly increased PM adherence to bovine lower respiratory tract epithelial cells. However, the molecular mechanisms of enhanced PM adherence are not completely understood. To investigate whether BRSV infection regulates any cellular adherence receptors on bovine bronchus- and lung-epithelial cells, we performed proteomic and functional analyses. The proteomic analysis showed that BRSV infection increased the accumulation of the platelet-activating factor receptor (PAFR) in both cell types. Molecular experiments, including specific blockade, knockdown, and overexpression of PAFR, indicated that PM adherence to these cell types depended on PAFR expression. These findings highlight the role, in cattle with severe pneumonia, of the synergistic effect of coinfection by BRSV and PM in the lower respiratory tract.
has issue date	2020-07-31(xsd:dateTime)
bibo:doi	10.3389/fmicb.2020.01676
bibo:pmid	32849350
has license	cc-by
sha1sum (hex)	d6d9dc77f14b3b92b4d67d06bd47df63ff7d083e
schema:url	https://doi.org/10.3389/fmicb.2020.01676
resource representing a document's title	Bovine Respiratory Syncytial Virus Enhances the Adherence of Pasteurella multocida to Bovine Lower Respiratory Tract Epithelial Cells by Upregulating the Platelet-Activating Factor Receptor
has PubMed Central identifier	PMC7411089
has PubMed identifier	32849350
schema:publication	Front Microbiol
resource representing a document's body	covid:d6d9dc77f14b3b92b4d67d06bd47df63ff7d083e#body_text
is schema:about of	named entity 'overexpression' named entity 'expression' covid:arg/d6d9dc77f14b3b92b4d67d06bd47df63ff7d083e named entity 'cellular' named entity 'synergistic' named entity 'infection' named entity 'respiratory syncytial virus' named entity 'knockdown' named entity 'highlight' named entity 'develop' named entity 'frequently' named entity 'Bovine' named entity 'Respiratory Syncytial Virus' named entity 'infection' named entity 'PAFR' named entity 'Pasteurella multocida' named entity 'Platelet-Activating Factor Receptor' named entity 'Upregulating' named entity 'viral RNA' named entity 'PAFR' named entity 'insulin' named entity 'bacteria' named entity 'Bovine' named entity 'RNA virus' named entity 'trachea' named entity 'NotI' named entity 'siRNA' named entity 'FITC' named entity 'gene' named entity 'cellular component' named entity 'cattle' named entity 'Abcam' named entity 'PAFR' named entity 'supernatant' named entity 'United States' named entity 'Promega' named entity 'ICAM-1' named entity 'TaKaRa Bio' named entity 'lower respiratory tract' named entity 'Japan' named entity 'transfected' named entity 'phosphatase inhibitor' named entity 'PAFR' named entity 'United States' named entity 'EGFP' named entity 'ultraviolet light' named entity 'dimethyl sulfoxide' named entity 'multiplicity of infection' named entity '87.75' named entity 'multiplicity of infection' named entity 'PAFR' named entity 'Thermo Fisher Scientific' named entity 'inflammatory factors' named entity 'genetic relationship' named entity 'TaKaRa Bio' named entity 'PAFR' named entity 'PAFR' named entity 'transferrin' named entity 'cattle' named entity 'RT-PCR' named entity 'bacteria' named entity 'S. pneumoniae' named entity 'antibody' named entity 'cDNA' named entity 'MOI' named entity 'siRNA' named entity 'bovine' named entity 'bacteria' named entity 'PAFR' named entity 'Japan' named entity 'dose-dependent manner' named entity 'immunoblotting'

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