About: Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus

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About: Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus
Creator	Chen, Chi-Min Wang, Ching-Ho Chueh, Ling-Ling Hsieh, Li-En Lin, Chao-Nan Su, Bi-Ling Jan, Tong-Rong Lin, Chung-Tien Lin, Dah-Sheng
Source	Elsevier; Medline; PMC
abstract	Abstract Feline infectious peritonitis (FIP) is a fatal disease in domestic and nondomestic felids caused by feline coronavirus (FCoV). Currently, no effective vaccine is available for the prevention of this disease. In searching for agents that may prove clinically effective against FCoV infection, 16 compounds were screened for their antiviral activity against a local FCoV strain in Felis catus whole fetus-4 cells. The results showed that Galanthus nivalis agglutinin (GNA) and nelfinavir effectively inhibited FCoV replication. When the amount of virus preinoculated into the test cells was increased to mimic the high viral load present in the target cells of FIP cats, GNA and nelfinavir by themselves lost their inhibitory effect. However, when the two agents were added together to FCoV-infected cells, a synergistic antiviral effect defined by complete blockage of viral replication was observed. These results suggest that the combined use of GNA and nelfinavir has therapeutic potential in the prophylaxis and treatment of cats with early-diagnosed FIP.
has issue date	2010-10-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2010.06.010
bibo:pmid	20603153
has license	els-covid
sha1sum (hex)	d6ff8bdef2d4f16621fbed72699b52c69939f103
schema:url	https://doi.org/10.1016/j.antiviral.2010.06.010
resource representing a document's title	Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus
has PubMed Central identifier	PMC7114315
has PubMed identifier	20603153
schema:publication	Antiviral Research
resource representing a document's body	covid:d6ff8bdef2d4f16621fbed72699b52c69939f103#body_text
is schema:about of	named entity 'lost' named entity 'compounds' named entity 'nelfinavir' named entity 'agents' named entity 'fetus' named entity 'combined' named entity 'GNA' named entity 'ANTIVIRAL ACTIVITY' named entity 'GALANTHUS NIVALIS' named entity 'SYNERGISTIC' named entity 'VIRAL LOAD' named entity 'VIRAL REPLICATION' named entity 'TARGET CELLS' named entity 'AVAILABLE' named entity 'OBSERVED' named entity 'FELIDS' covid:arg/d6ff8bdef2d4f16621fbed72699b52c69939f103 named entity 'POTENTIAL' named entity 'EFFECT' named entity 'NELFINAVIR' named entity 'FATAL DISEASE' named entity 'COMPLETE BLOCKAGE' named entity 'ADDED' named entity 'THESE' named entity 'STRAIN' named entity 'COMBINED' named entity 'TEST' named entity 'RESULTS' named entity 'INFECTED' named entity 'IS A' named entity 'MIMIC' named entity 'THEIR' named entity 'INHIBITORY EFFECT' named entity 'FETUS' named entity 'DEFINED' named entity 'AGGLUTININ' named entity 'FELIS CATUS' named entity 'REPLICATION' named entity 'INFECTION' named entity 'ANTIVIRAL' named entity 'DIAGNOSED' named entity 'USE OF' named entity 'PRESENT' named entity 'INHIBITED' named entity 'FELINE INFECTIOUS PERITONITIS' named entity 'EFFECT' named entity 'NELFINAVIR' named entity 'ANTIVIRAL' named entity 'GALANTHUS NIVALIS' named entity 'SYNERGISTIC' named entity 'INCREASED' named entity 'LOST' named entity 'EARLY' named entity 'SUGGEST' named entity 'CELLS' named entity 'THERAPEUTIC' named entity 'PROPHYLAXIS' named entity 'FELINE CORONAVIRUS' named entity 'CAUSED BY' named entity 'PREVENTION OF' named entity 'EFFECTIVE' named entity 'CATS' named entity 'TREATMENT' named entity 'VACCINE' named entity 'VIRUS' named entity 'HIGH' named entity 'FIP' named entity 'CURRENTLY' named entity 'DISEASE' named entity 'DOMESTIC' named entity 'LOCAL' named entity 'AGGLUTININ' named entity 'FELINE CORONAVIRUS'

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