About: Association of Candidate Genes with Response to Heat and Newcastle Disease Virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association of Candidate Genes with Response to Heat and Newcastle Disease Virus
Creator	Wang, Ying Saelao, Perot Zhou, Huaijun Kelly, Terra Dekkers, Jack Gallardo, Rodrigo Fulton, Janet Lamont, Susan Liebe, Grant Mccarron, Amy Rowland, Kaylee Wolc, Anna
Source	PMC
abstract	Newcastle disease is considered the number one disease constraint to poultry production in low and middle-income countries, however poultry that is raised in resource-poor areas often experience multiple environmental challenges. Heat stress has a negative impact on production, and immune response to pathogens can be negatively modulated by heat stress. Candidate genes and regions chosen for this study were based on previously reported associations with response to immune stimulants, pathogens, or heat, including: TLR3, TLR7, MX, MHC-B (major histocompatibility complex, gene complex), IFI27L2, SLC5A1, HSPB1, HSPA2, HSPA8, IFRD1, IL18R1, IL1R1, AP2A2, and TOLLIP. Chickens of a commercial egg-laying line were infected with a lentogenic strain of NDV (Newcastle disease virus); half the birds were maintained at thermoneutral temperature and the other half were exposed to high ambient temperature before the NDV challenge and throughout the remainder of the study. Phenotypic responses to heat, to NDV, or to heat + NDV were measured. Selected SNPs (single nucleotide polymorphisms) within 14 target genes or regions were genotyped; and genotype effects on phenotypic responses to NDV or heat + NDV were tested in each individual treatment group and the combined groups. Seventeen significant haplotype effects, among seven genes and seven phenotypes, were detected for response to NDV or heat or NDV + heat. These findings identify specific genetic variants that are associated with response to heat and/or NDV which may be useful in the genetic improvement of chickens to perform favorably when faced with pathogens and heat stress.
has issue date	2018-11-19(xsd:dateTime)
bibo:doi	10.3390/genes9110560
bibo:pmid	30463235
has license	cc-by
sha1sum (hex)	d729eef3818cc854484ab0550aa245e5eaa2b72e
schema:url	https://doi.org/10.3390/genes9110560
resource representing a document's title	Association of Candidate Genes with Response to Heat and Newcastle Disease Virus
has PubMed Central identifier	PMC6267452
has PubMed identifier	30463235
schema:publication	Genes (Basel)
resource representing a document's body	covid:d729eef3818cc854484ab0550aa245e5eaa2b72e#body_text
is schema:about of	named entity 'pathogens' named entity 'combined' named entity 'effects' named entity 'CANDIDATE GENES' named entity 'GENE' named entity 'MEASURED' named entity 'NEWCASTLE DISEASE' named entity 'HSPA2' named entity 'RESOURCE' named entity 'STUDY' named entity 'EXPERIENCE' named entity 'TREATMENT GROUP' named entity 'IMPROVEMENT' named entity 'DISEASE' named entity 'SPECIFIC' named entity 'HISTOCOMPATIBILITY COMPLEX' named entity 'PHENOTYPES' named entity 'MAY BE' named entity 'INCLUDING' named entity 'DETECTED' named entity 'ASSOCIATED WITH' named entity 'FACED' named entity 'REPORTED' named entity 'EXPOSED TO' named entity 'CANDIDATE GENES' named entity 'CHICKENS' named entity 'INCOME' named entity 'INFECTED' named entity 'SEVEN' named entity 'VARIANTS' named entity 'STRAIN' named entity 'IFI27L2' named entity 'USEFUL' named entity 'RESPONSES' named entity 'SNPS' named entity 'SEVENTEEN' named entity 'IL18R1' named entity 'NEWCASTLE DISEASE VIRUS' named entity 'PRODUCTION' named entity 'AMBIENT TEMPERATURE' named entity 'POOR' named entity 'MULTIPLE' named entity 'POULTRY PRODUCTION' named entity 'COMMERCIAL' named entity 'CONSTRAINT' named entity 'DISEASE VIRUS' named entity 'NUMBER' named entity 'BIRDS' named entity 'SLC5A1' named entity 'GENES' named entity 'PREVIOUSLY' named entity 'REGIONS' named entity 'EFFECTS' named entity 'TLR3' named entity 'IMMUNE RESPONSE' named entity 'GENETIC' named entity 'COMBINED' named entity 'IL1R1' named entity 'TO HEAT' named entity 'HEAT STRESS' named entity 'SIGNIFICANT' named entity 'TEMPERATURE' named entity 'LOW' named entity 'NEGATIVE' named entity 'HSPA8' named entity 'RESPONSE TO HEAT' named entity 'TLR7' named entity 'BASED' named entity 'POULTRY' named entity 'CONSIDERED'

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