About: Clinical Features of Coronavirus Disease 2019 Patients With Mechanical Ventilation: A Nationwide Study in China

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical Features of Coronavirus Disease 2019 Patients With Mechanical Ventilation: A Nationwide Study in China
Creator	Wang, Tao Li, Shiyue Zhong, Chen, Ruchong Guan, Weijie Liang, Wenhua Nanshan, Ruan, Honglian Sang, Ling Tang, Chunli Tang, Ruidi
Source	Medline; PMC
abstract	OBJECTIVES: The outbreak of coronavirus disease 2019 is becoming a worldwide pandemic. Mechanical ventilation is lifesaving for respiratory distress, this study was designed to delineate the clinical features of the coronavirus disease 2019 patients with mechanical ventilation from a national cohort in China. DESIGN: Prospective observational study. SETTING: The rapid spread of severe acute respiratory syndrome coronavirus 2 has infected more than 7.7 million people and caused more than 423,000 deaths. PATIENTS: Adult hospitalized coronavirus disease 2019 patients with mechanical ventilation from 557 hospitals from China. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: From a nationwide cohort, 141 coronavirus disease 2019 cases with mechanical ventilation were extracted from 1,590 cases. Cigarette smoke, advanced age, coexisting chronic illness, elevated systolic blood pressure, high body temperature, and abnormal laboratory findings are common in these ventilated cases. Multivariate regression analysis showed that higher odds of in-hospital death was associated with invasive mechanical ventilation requirement (hazard ratio: 2.95; 95% CI, 1.40–6.23; p = 0.005), and coexisting chronic obstructive pulmonary disease (hazard ratio, 4.57; 95% CI, 1.65–12.69; p = 0.004) and chronic renal disease (hazard ratio, 5.45; 95% CI, 1.85–16.12; p = 0.002). Compared with patients with noninvasive mechanical ventilation, patients who needs invasive mechanical ventilation showed higher rate of elevated d-dimer (> 1.5 mg/L) at admission (hazard ratio, 3.28, 95% CI, 1.07–10.10; p = 0.039). CONCLUSIONS: The potential risk factors of elevated d-dimer level could help clinicians to identify invasive mechanical ventilation requirement at an early stage, and coexisting chronic obstructive pulmonary disease or chronic renal disease are independent risk factors associated with fatal outcome in coronavirus disease 2019 patients with mechanical ventilation.
has issue date	2020-06-23(xsd:dateTime)
bibo:doi	10.1097/ccm.0000000000004473
bibo:pmid	32618693
has license	no-cc
sha1sum (hex)	d73a4054a8519f2984ee4863ecea753f195914c1
schema:url	https://doi.org/10.1097/ccm.0000000000004473
resource representing a document's title	Clinical Features of Coronavirus Disease 2019 Patients With Mechanical Ventilation: A Nationwide Study in China
has PubMed Central identifier	PMC7314346
has PubMed identifier	32618693
schema:publication	Crit Care Med
resource representing a document's body	covid:d73a4054a8519f2984ee4863ecea753f195914c1#body_text
is schema:about of	named entity 'outbreak' named entity 'mechanical ventilation' named entity 'hazard ratio' named entity 'Objectives' named entity 'higher' named entity 'Disease' named entity 'NONINVASIVE MECHANICAL VENTILATION' named entity 'CIGARETTE SMOKE' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'COHORT' named entity 'INFECTED' named entity 'STUDY' named entity 'ELEVATED D-DIMER' named entity 'PEOPLE' named entity 'CLINICAL FEATURES' named entity 'HOSPITAL DEATH' named entity 'mechanical ventilation' named entity 'Interventions' named entity '95% CI' named entity 'Measurements' named entity 'admission' named entity 'mechanical ventilation' named entity 'abnormal' named entity 'Study' named entity 'hazard ratio' named entity 'Cigarette smoke' named entity 'mechanical ventilation' named entity 'coronavirus disease 2019' named entity 'coronavirus disease 2019' named entity '95% CI' named entity 'clinical features' named entity 'invasive mechanical ventilation' named entity 'chronic illness' named entity '95% CI' named entity 'mechanical ventilation' named entity 'hazard ratio' named entity 'mechanical ventilation' named entity 'COVID-19 outbreak' named entity 'dyspnea' named entity 'albumin' named entity 'oxygen therapy' named entity 'National Health Commission' named entity 'diabetes' named entity 'COVID-19 outbreak' named entity 'People's Republic of China' named entity 'oxygen saturation' named entity 'China' named entity 'aspartate aminotransferase' named entity 'COVID-19 outbreak' named entity 'China' named entity 'National Health Commission' named entity 'C-reactive protein' named entity 'IQR' named entity 'chronic obstructive pulmonary disease' named entity 'mechanical ventilation' named entity 'COVID' named entity 'NIV' named entity 'respiratory distress' named entity 'critically ill' named entity 'NIV' named entity 'medical conditions' named entity 'hypertension' named entity 'SARS-CoV-2' named entity 'Treatment Protocol' named entity 'mechanical ventilation' named entity 'lactate dehydrogenase' named entity 'hazard ratio' named entity 'CRP' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'NIV'

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