About: Impact of Multiplex Polymerase Chain Reaction Testing for Respiratory Pathogens on Healthcare Resource Utilization for Pediatric Inpatients

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About: Impact of Multiplex Polymerase Chain Reaction Testing for Respiratory Pathogens on Healthcare Resource Utilization for Pediatric Inpatients Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Impact of Multiplex Polymerase Chain Reaction Testing for Respiratory Pathogens on Healthcare Resource Utilization for Pediatric Inpatients
Creator	Saiman, Lisa Zachariah, Philip Whittier, Susan Krones, Ariella Subramony, Anupama
source	Elsevier; Medline; PMC
abstract	OBJECTIVE: To assess whether multiplex polymerase chain reaction (mPCR) vs. non-MPCR testing impacts the use of antibiotics, chest radiographs, and isolation precautions. STUDY DESIGN: We retrospectively compared use of antibiotics, chest radiographs, and isolation precautions for patients <18 years old (excluding neonates) hospitalized at a tertiary referral center tested for respiratory pathogens in the emergency department or during the first 2 hospital days, during two periods: June 2010–June 2012 (non-MPCR group) vs. October 2012-May 2014 (MPCR group). RESULTS: Subjects (n=2430) in the MPCR group were older, had more complex chronic conditions, and were admitted to the PICU more often compared with the non-MPCR (n=2349) group. Subjects in the MPCR group had more positive tests (42.4% vs. 14.4%, p<0.01), received fewer days of antibiotics (4 vs. 5 median antibiotic days, p<0.01), fewer chest radiographs performed, (59% vs. 78%, p<0.01), and were placed in isolation longer (20 vs. 0 median isolation-hours, p<0.01) compared with the non-MPCR group. In multivariable regression, patients tested with MPCR were less likely to receive antibiotics for ≥2 days (OR 0.5, 95% CI 0.5-0.6), chest radiographs at admission (OR 0.4, 95% CI 0.3-0.4), and more likely to be in isolation for ≥2 days (OR 2.4, 95% CI 2.1-2.8 compared with the non- MPCR group. CONCLUSIONS: Use of MPCR testing for respiratory viruses among hospitalized patients was significantly associated with decreased healthcare resource utilization, including decreased use of antibiotics and chest radiographs, and increased use of isolation precautions.
has issue date	2016-06-01(xsd:dateTime)
bibo:doi	10.1016/j.jpeds.2016.02.050
bibo:pmid	27039227
has license	green-oa
sha1sum (hex)	d75380a926b9ea6698854fb6bd9b8b48a7c5f309
schema:url	https://doi.org/10.1016/j.jpeds.2016.02.050
resource representing a document's title	Impact of Multiplex Polymerase Chain Reaction Testing for Respiratory Pathogens on Healthcare Resource Utilization for Pediatric Inpatients
has PubMed Central identifier	PMC5452417
has PubMed identifier	27039227
schema:publication	The Journal of Pediatrics
resource representing a document's body	covid:d75380a926b9ea6698854fb6bd9b8b48a7c5f309#body_text
is schema:about of	named entity 'Utilization' named entity 'Healthcare' named entity 'HHS' named entity 'Pediatric' named entity 'PEDIATRIC' named entity 'HHS' named entity 'CHEST' named entity 'USE OF' named entity 'RADIOGRAPHS' named entity 'OBJECTIVE' named entity 'MULTIPLEX POLYMERASE CHAIN REACTION' named entity 'ASSESS' named entity 'TESTING' named entity 'ISOLATION PRECAUTIONS' named entity 'IMPACT' named entity 'PUBLIC' named entity 'ACCESS' named entity 'RESPIRATORY PATHOGENS' named entity 'MULTIPLEX POLYMERASE CHAIN REACTION' named entity 'HEALTHCARE RESOURCE UTILIZATION' named entity 'INPATIENTS' named entity 'ANTIBIOTICS' named entity 'NON-' named entity 'IMPACTS' named entity 'TESTING' named entity 'chain reaction' named entity 'polymerase chain reaction' named entity 'ICD-9' named entity 'antibiotic' named entity 'hospital admission' named entity 'regression analysis' named entity 'viruses' named entity 'positive test' named entity 'calendar days' named entity 'turnaround time' named entity 'radiographs' named entity 'Mycoplasma' named entity 'electronic medical record' named entity 'antibiotic' named entity 'radiation exposure' named entity 'data warehouse' named entity 'Columbia University Medical Center' named entity 'chest radiograph' named entity 'pathogens' named entity 'positive test' named entity 'viral infections' named entity 'antibiotic therapy' named entity 'Newborns' named entity 'Health Information' named entity 'EMR' named entity 'NewYork-Presbyterian' named entity 'viruses' named entity 'Bivariate analysis' named entity 'chi-squared test' named entity 'pediatric' named entity 'pediatric intensive care unit' named entity 'antibiotics' named entity 'etiology' named entity 'pathogens' named entity 'antibiotic therapy' named entity 'chest radiograph' named entity 'chest radiograph' named entity 'antibiotics' named entity 'reference group' named entity 'chest radiograph' named entity 'study population' named entity 'Demographic' named entity 'Children's Hospital Association' named entity 'antibiotic' named entity 'RSV' named entity 'ICD-9' named entity 'antibiotic' named entity 'pathogen' named entity 'study population' named entity 'Morgan Stanley Children's Hospital' named entity 'turnaround time' named entity 'pathogens'

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