About: Nucleotide-Resolution Profiling of RNA Recombination in the Encapsidated Genome of a Eukaryotic RNAVirus by Next-Generation Sequencing

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About: Nucleotide-Resolution Profiling of RNA Recombination in the Encapsidated Genome of a Eukaryotic RNAVirus by Next-Generation Sequencing Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nucleotide-Resolution Profiling of RNA Recombination in the Encapsidated Genome of a Eukaryotic RNAVirus by Next-Generation Sequencing
Creator	Routh, Andrew Ordoukhanian, Phillip Johnson, John
topic	covid:d7e5ba009aed400fac0a223f7fe364b16ac84ae6#this
Source	Elsevier; Medline; PMC
abstract	Next-Generation Sequencing has been used in numerous investigations to characterize andquantifythe genetic diversity of a virus samplethrough the mapping of polymorphisms and measurement of mutation frequencies.Next-Generation Sequencing has also been employed to identifyrecombinationevents occurring within the genomes of higher organisms, for example, detecting alternative RNA splicing events and oncogenic chromosomal rearrangements. Here, we combine these two approaches toprofile RNA recombination within the encapsidated genome of a eukaryotic RNA virus, Flock House Virus. We detect hundreds of thousands of recombination events, with single-nucleotide resolution, which result indiversity in the encapsidated genome rivaling that due to mismatch mutation. We detect previously identified Defective-RNAs as well as many other abundant and novel Defective-RNAs. Our approach is exceptionally sensitive, unbiased, and requires no prior knowledge beyond the virus genome sequence. RNA recombination is a powerful driving force behind the evolution and adaptation of RNA viruses. The strategy implemented here is widely applicable and provides a highly detailed description of the complex mutational landscape of the transmissible viral genome.
has issue date	2012-12-01(xsd:dateTime)
bibo:doi	10.1016/j.jmb.2012.10.005
bibo:pmid	23069247
has license	green-oa
sha1sum (hex)	d7e5ba009aed400fac0a223f7fe364b16ac84ae6
schema:url	https://doi.org/10.1016/j.jmb.2012.10.005
resource representing a document's title	Nucleotide-Resolution Profiling of RNA Recombination in the Encapsidated Genome of a Eukaryotic RNAVirus by Next-Generation Sequencing
has PubMed Central identifier	PMC3502730
has PubMed identifier	23069247
schema:publication	Journal of Molecular Biology
resource representing a document's body	covid:d7e5ba009aed400fac0a223f7fe364b16ac84ae6#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/d7e5ba009aed400fac0a223f7fe364b16ac84ae6
is schema:about of	named entity 'EUKARYOTIC' named entity 'virus' named entity 'hundreds' named entity 'Our' named entity 'measurement' named entity 'genome' named entity 'investigations' named entity 'Profiling' named entity 'GENERATION' named entity 'POLYMORPHISMS' named entity 'NOVEL' named entity 'VIRUS' named entity 'COMBINE' named entity 'COMPLEX' named entity 'MUTATION' named entity 'DETAILED' named entity 'HIGHER' named entity 'FLOCK HOUSE VIRUS' named entity 'CHROMOSOMAL REARRANGEMENTS' named entity 'PROVIDES' named entity 'MISMATCH' named entity 'GENETIC DIVERSITY' named entity 'DESCRIPTION' named entity 'FREQUENCIES' named entity 'NUCLEOTIDE' named entity 'GENOME' named entity 'RESOLUTION' named entity 'SEQUENCING' named entity 'RNA RECOMBINATION' named entity 'GENOMES' named entity 'GENOME' named entity 'RNA VIRUSES' named entity 'STRATEGY' named entity 'APPLICABLE' named entity 'INVESTIGATIONS' named entity 'ABUNDANT' named entity 'SINGLE' named entity 'IDENTIFIED' named entity 'ORGANISMS' named entity 'POWERFUL' named entity 'RESULT' named entity 'ALTERNATIVE' named entity 'GENOME SEQUENCE' named entity 'ADAPTATION' named entity 'SENSITIVE' named entity 'PRIOR' named entity 'MAPPING' named entity 'EXAMPLE' named entity 'RECOMBINATION' named entity 'RESOLUTION' named entity 'RNA VIRUS' named entity 'LANDSCAPE' named entity 'DRIVING' named entity 'THESE' named entity 'EUKARYOTIC' named entity 'PREVIOUSLY' named entity 'IS A' named entity 'DUE TO' named entity 'RNAS' named entity 'NUMEROUS' named entity 'NUCLEOTIDE' named entity 'DETECTING' named entity 'NEXT-GENERATION SEQUENCING' named entity 'IMPLEMENTED' named entity 'KNOWLEDGE' named entity 'DEFECTIVE' named entity 'TO CHARACTERIZE' named entity 'DETECT' named entity 'BEYOND' named entity 'RNA RECOMBINATION' named entity 'RNA SPLICING' named entity 'MEASUREMENT' named entity 'EMPLOYED' named entity 'VIRAL GENOME' named entity 'FORCE' named entity 'APPROACHES' named entity 'EVOLUTION'

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