About: Therapeutic spectrum of interferon‐β in ischemic stroke

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About: Therapeutic spectrum of interferon‐β in ischemic stroke Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Therapeutic spectrum of interferon‐β in ischemic stroke
Creator	Sarmah, Deepaneeta Borah, Anupom Kaur, Harpreet Saraf, Jackson Wanve, Madhuri Dave, R Dileep, \| Kanchan Vats, \| Kanta Pravalika, \| Kiran Kalia, \| Kunjan, \| Pallab Bhattacharya, \| Yavagal, R
source	PMC
abstract	Ischemic stroke is devastating and a major cause of morbidity and mortality worldwide. To date, only clot retrieval devices and/or intravenous tissue plasminogen activators (tPA) have been approved by the US‐FDA for the treatment of acute ischemic stroke. Therefore, there is an urgent need to develop an effective treatment for stroke that can have limited shortcomings and broad spectrum of applications. Interferon‐beta (IFN‐β), an endogenous cytokine and a key anti‐inflammatory agent, contributes toward obviating deleterious stroke outcomes. Therefore, exploring the role of IFN‐β may be a promising alternative approach for stroke intervention in the future. In the present review, we have discussed about IFN‐β along with its different mechanistic roles in ischemic stroke. Furthermore, therapeutic approaches targeting the inflammatory cascade with IFN‐β therapy that may be helpful in improving stroke outcome are also discussed.
has issue date	2018-10-15(xsd:dateTime)
bibo:doi	10.1002/jnr.24333
bibo:pmid	30320448
has license	no-cc
sha1sum (hex)	d7ed6431a806223fc332551cd6b85c14b9bb0197
schema:url	https://doi.org/10.1002/jnr.24333
resource representing a document's title	Therapeutic spectrum of interferon‐β in ischemic stroke
has PubMed Central identifier	PMC7167007
has PubMed identifier	30320448
schema:publication	J Neurosci Res
resource representing a document's body	covid:d7ed6431a806223fc332551cd6b85c14b9bb0197#body_text
is schema:about of	named entity 'MORBIDITY AND MORTALITY' named entity 'ISCHEMIC STROKE' named entity 'CAUSE' named entity 'EFFECTIVE' named entity 'NEED' named entity 'LIMITED' named entity 'DATE' named entity 'Ischemic stroke' named entity 'stroke' named entity 'broad spectrum' named entity 'morbidity' named entity 'US-FDA' named entity 'ischemic stroke' named entity 'headache' named entity 'BBB' named entity 'permeability' named entity 'stroke' named entity 'protein' named entity 'Interferon-β' named entity 'innate immunity' named entity 'inflammatory conditions' named entity 'Harvard Medical School' named entity 'chemokine' named entity 'Depression' named entity 'Cerebral ischemic injury' named entity 'nitric oxide' named entity 'caspases' named entity 'inhibitor of apoptosis' named entity 'chemokine' named entity 'adhesion molecules' named entity 'dramatic increase' named entity 'ischemic' named entity 'microvascular injury' named entity 'neutrophils' named entity 'IL-1B' named entity 'colorectal cancer' named entity 'DNA sequence' named entity 'neuroinflammation' named entity 'reperfusion' named entity 'ischemic injury' named entity 'allergic diseases' named entity 'dendritic cells' named entity 'transmembrane receptor' named entity 'inflammatory cells' named entity 'reperfusion' named entity 'multiple sclerosis' named entity 'monocytes' named entity 'B-cell lymphoma 2' named entity 'immunomodulatory' named entity 'macrophages' named entity 'cerebral ischemia' named entity 'myalgia' named entity 'TNF-related apoptosis-inducing ligand' named entity 'contralateral' named entity 'Interferon' named entity 'E-selectin' named entity 'blood vessels' named entity 'ischemia' named entity 'inflammatory cytokines' named entity 'endothelial' named entity 'excitotoxicity' named entity 'Ischemic injury' named entity 'pro-apoptotic' named entity 'neurons' named entity 'neurodegeneration' named entity 'IFNAR' named entity 'IFN-β' named entity 'stroke' named entity 'anti-inflammatory agent'

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