About: Polymer-Based DNA Delivery Systems for Cancer Immunotherapy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Polymer-Based DNA Delivery Systems for Cancer Immunotherapy
Creator	David, Ayelet Golani-Armon, Adi
Source	PMC
abstract	The use of gene delivery systems for the expression of antigenic proteins is an established means for activating a patient’s own immune system against the cancer they carry. Since tumor cells are poor antigen-presenting cells, cross-presentation of tumor antigens by dendritic cells (DCs) is essential for the generation of tumor-specific cytotoxic T-lymphocyte responses. A number of polymer-based nanomedicines have been developed to deliver genes into DCs, primarily by incorporating tumor-specific, antigen-encoding plasmid DNA with polycationic molecules to facilitate DNA loading and intracellular trafficking. Direct in vivo targeting of plasmid DNA to DC surface receptors can induce high transfection efficiency and long-term gene expression, essential for antigen loading onto major histocompatibility complex molecules and stimulation of T-cell responses. This chapter summarizes the physicochemical properties and biological information on polymer-based non-viral vectors used for targeting DCs, and discusses the main challenges for successful in vivo gene transfer into DCs.
has issue date	2016-05-28(xsd:dateTime)
bibo:doi	10.1007/978-1-4939-3634-2_10
has license	no-cc
sha1sum (hex)	d83f69ae51adcbeef41dd3d1f432e93f86dd14f0
schema:url	https://doi.org/10.1007/978-1-4939-3634-2_10
resource representing a document's title	Polymer-Based DNA Delivery Systems for Cancer Immunotherapy
has PubMed Central identifier	PMC7153417
schema:publication	Nanomedicine
resource representing a document's body	covid:d83f69ae51adcbeef41dd3d1f432e93f86dd14f0#body_text
is schema:about of	named entity 'dendritic cells' named entity 'gene' named entity 'antigen-presenting cells' named entity 'SUCCESSFUL' named entity 'MAIN' named entity 'GENE DELIVERY' named entity 'TUMOR CELLS' named entity 'summarizes' named entity 'vectors' named entity 'expression' named entity 'transfection' named entity 'essential' named entity 'The' named entity 'plasmid' named entity 'vivo' named entity 'major histocompatibility complex' named entity 'patient' named entity 'plasmid' named entity 'tumor cells' named entity 'intracellular' named entity 'stimulation' named entity 'gene delivery' named entity 'tumor cells' named entity 'surface receptors' named entity 'polymer' named entity 'tumor' named entity 'gene expression' named entity 'polymer' named entity 'Chitosan' named entity 'anti-tumor immunity' named entity 'viral vectors' named entity 'tumor' named entity 'chemotherapy' named entity 'chemotherapy' named entity 'macrophages' named entity 'negatively charged' named entity 'cytotoxicity' named entity 'ethylene glycol' named entity 'antigens' named entity 'cell surface' named entity 'peptide' named entity 'NLS' named entity 'carbohydrate' named entity 'cytotoxic T-cells' named entity 'hydrolysis' named entity 'nucleic acids' named entity 'immune cells' named entity 'antigens' named entity 'macrophages' named entity 'DCs' named entity 'protein' named entity 'DC-SIGN' named entity 'cross-presentation' named entity 'transfection' named entity 'molecule' named entity 'cross-presentation' named entity 'lactide' named entity 'adsorption' named entity 'transfection' named entity 'dendrimers' named entity 'mucus' named entity 'protonated' named entity 'PLGA' named entity 'polypeptide' named entity 'helper cells' named entity 'cytotoxicity' named entity 'endocytosis' named entity 'T-cells' named entity 'MHC' named entity 'nanoparticles' named entity 'class I molecules' named entity 'nucleus' named entity 'PLGA' named entity 'peptide' named entity 'tumor cells' named entity 'FDA' named entity 'DCs' named entity 'DCs' named entity 'tumor' named entity 'CD4 +' named entity 'CD8+ T-cells' named entity 'DCs'

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