About: Fidelity Variants and RNA Quasispecies

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Fidelity Variants and RNA Quasispecies
Creator	Vignuzzi, Marco Rozen-Gagnon, Kathryn Bordería, Antonio
Source	Medline; PMC
abstract	By now, it is well established that the error rate of the RNA-dependent RNA polymerase (RdRp) that replicates RNA virus genomes is a primary driver of the mutation frequencies observed in RNA virus populations—the basis for the RNA quasispecies. Over the last 10 years, a considerable amount of work has uncovered the molecular determinants of replication fidelity in this enzyme. The isolation of high- and low-fidelity variants for several RNA viruses, in an expanding number of viral families, provides evidence that nature has optimized the fidelity to facilitate genetic diversity and adaptation, while maintaining genetic integrity and infectivity. This chapter will provide an overview of what fidelity variants tell us about RNA virus biology and how they may be used in antiviral approaches.
has issue date	2015-10-25(xsd:dateTime)
bibo:doi	10.1007/82_2015_483
bibo:pmid	26499340
has license	no-cc
sha1sum (hex)	d848c3ff28c0717b135f3030d9576568c12d389d
schema:url	https://doi.org/10.1007/82_2015_483
resource representing a document's title	Fidelity Variants and RNA Quasispecies
has PubMed Central identifier	PMC7121553
has PubMed identifier	26499340
schema:publication	Quasispecies: From Theory to Experimental Systems
resource representing a document's body	covid:d848c3ff28c0717b135f3030d9576568c12d389d#body_text
is schema:about of	named entity 'quasispecies' named entity 'nature' named entity 'expanding' named entity 'genomes' named entity 'biology' named entity 'ISOLATION' named entity 'BIOLOGY' named entity 'GENOMES' named entity 'ENZYME' named entity 'MAINTAINING' named entity 'FAMILIES' named entity 'DRIVER' named entity 'REPLICATES' named entity 'VIRAL' named entity 'PRIMARY' named entity 'ANTIVIRAL' named entity 'NATURE' named entity 'RNA-DEPENDENT RNA POLYMERASE' named entity 'MOLECULAR' named entity 'DETERMINANTS' named entity 'OVERVIEW' named entity 'GENETIC' named entity 'OBSERVED' named entity 'WHAT' named entity 'POPULATIONS' named entity 'HOW' named entity 'UNCOVERED' named entity 'FIDELITY' named entity 'RNA VIRUS' named entity 'WORK' named entity 'ABOUT' named entity 'ESTABLISHED' named entity 'ADAPTATION' named entity 'IS A' named entity 'NUMBER OF' named entity 'BASIS' named entity 'HIGH' named entity 'VARIANTS' named entity 'INFECTIVITY' named entity 'RNA VIRUSES' named entity 'YEARS' named entity 'FIDELITY' named entity 'QUASISPECIES' named entity 'LOW' named entity 'PROVIDES' named entity 'RATE' named entity 'MUTATION' named entity 'FREQUENCIES' named entity 'EVIDENCE' named entity 'MAY BE' named entity 'ERROR' named entity 'EXPANDING' named entity 'INTEGRITY' named entity 'CHAPTER' named entity 'USED' named entity 'QUASISPECIES' named entity 'RNA' named entity 'GENETIC DIVERSITY' named entity 'RNA' named entity 'VARIANTS' named entity 'REPLICATION' named entity 'APPROACHES' named entity 'PROVIDE' named entity 'CONSIDERABLE' named entity 'genetic diversity' named entity 'RNA' named entity 'RNA virus' named entity 'mutation' named entity 'polymerase' named entity 'RNA virus' named entity 'RNA virus' named entity 'genetic diversity' named entity 'RNA' named entity 'RNA virus' named entity 'adaptation' named entity 'human rhinovirus' named entity 'relative fitness' named entity 'motif' named entity 'mosquito'

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