About: The R-rich motif of Beet black scorch virus P7a movement protein is important for the nuclear localization, nucleolar targeting and viral infectivity

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About: The R-rich motif of Beet black scorch virus P7a movement protein is important for the nuclear localization, nucleolar targeting and viral infectivity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The R-rich motif of Beet black scorch virus P7a movement protein is important for the nuclear localization, nucleolar targeting and viral infectivity
Creator	Li, Dawei Xu, Jin Wang, Xiaohui Zhang, Yanjing Yu, Jialin Fan, Huiyan Han, Chenggui Shi, Lindan
Source	Elsevier; Medline; PMC
abstract	Abstract Beet black scorch virus (BBSV) encodes three movement proteins (P7a, P7b and P5′) that facilitate its cell-to-cell movement. An arginine-rich motif of P7a N-terminus was found to determine nuclear and nucleolar localization. Amino acids substitution or deletion of the R-rich motif interfered with P7a nuclear and nucleolar localization. Bimolecular fluorescence complementation (BiFC) assays revealed that P7a protein interacted with Nicotiana benthamiana nuclear import factor importin α, suggesting that P7a is translocated into the nucleus by the classical importin α/β-dependent pathway. Moreover, P7a also interacted with the nucleolar protein fibrillarin. Mutations in the R-rich motif of P7a diminished P7a interactions with importin α and fibrillarin, influenced viral replication in Nicotiana benthamiana protoplasts and altered the symptom phenotype and viral RNA accumulation in Chenopodium amaranticolor plants. These results demonstrate that the R-rich motif of P7a is correlated with nuclear and nucleolar localization, viral replication and virus infection.
has issue date	2012-08-31(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2012.05.001
bibo:pmid	22626884
has license	els-covid
sha1sum (hex)	d85a3d285c1ae63ad4ea605baa4efda4dd137652
schema:url	https://doi.org/10.1016/j.virusres.2012.05.001
resource representing a document's title	The R-rich motif of Beet black scorch virus P7a movement protein is important for the nuclear localization, nucleolar targeting and viral infectivity
has PubMed Central identifier	PMC7172424
has PubMed identifier	22626884
schema:publication	Virus Research
resource representing a document's body	covid:d85a3d285c1ae63ad4ea605baa4efda4dd137652#body_text
is schema:about of	named entity 'protoplasts' named entity 'nuclear' named entity 'nuclear' named entity 'Beet' named entity 'importin' named entity 'localization' named entity 'infectivity' named entity 'scorch' named entity 'deletion' named entity 'phenotype' named entity 'importin' named entity 'virus' named entity 'localization' named entity 'fibrillarin' named entity 'protein' named entity 'viral replication' named entity 'Nicotiana benthamiana' named entity 'motif' named entity 'virus infection' named entity 'nuclear import' named entity 'arginine' named entity 'viral RNA' named entity 'motif' named entity 'movement proteins' named entity 'symptom' named entity 'nuclear localization' named entity 'nuclear export' named entity 'infection' named entity 'lesion' named entity 'GST-tag' named entity 'Tobacco necrosis virus' named entity 'amino acids' named entity 'viral replication' named entity 'virus' named entity 'cytoplasm' named entity 'northern blot analysis' named entity 'Ran-GTP' named entity 'fluorescence' named entity 'nucleolus' named entity 'scanning microscopy' named entity 'agroinfiltration' named entity 'transfected' named entity 'coding sequence' named entity 'protein' named entity 'RNA virus' named entity 'viral infection' named entity 'cDNA' named entity 'cytoplasm' named entity 'importin' named entity 'Invitrogen' named entity 'nucleotide sequence' named entity 'phenotypes' named entity 'nuclear localization' named entity 'Primer' named entity 'VPg' named entity 'nucleus' named entity 'Agrobacterium' named entity 'plasmid' named entity 'fluorescein' named entity 'nucleolus' named entity 'genus' named entity 'northern blot analysis' named entity 'nucleus' named entity 'protein' named entity 'amino acid' named entity 'loading control' named entity '2-phenylindole' named entity 'protein' named entity 'nucleolus' named entity 'Agrobacterium tumefaciens' named entity '30 mM' named entity 'viral replication' named entity 'northern blot analysis' named entity 'VPg'

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