About: Evaluation of Ultra-Microscopic Changes and Proliferation of Apoptotic Glioblastoma Multiforme Cells Induced by Velogenic Strain of Newcastle Disease Virus AF2240

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Evaluation of Ultra-Microscopic Changes and Proliferation of Apoptotic Glioblastoma Multiforme Cells Induced by Velogenic Strain of Newcastle Disease Virus AF2240 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of Ultra-Microscopic Changes and Proliferation of Apoptotic Glioblastoma Multiforme Cells Induced by Velogenic Strain of Newcastle Disease Virus AF2240
Creator	Yusoff, Khatijah Ali-Saeed, Rola Ideris, Aini Alabsi, Aied Ali, Abdul Rahman Omar, Abdul
Source	PMC
abstract	AIM: Newcastle disease virus (NDV) is a member of genus Avulavirus within the family Paramyxoviridae. Interest of using NDV as an anticancer agent has arisen from its ability to kill tumor cells with limited toxicity to normal cells. METHODS: In this investigation, the proliferation of brain tumor cell line, glioblastoma multiform (DBTRG.05MG) induced by NDV strain AF2240 was evaluated in-vitro, by using MTT proliferation assay. Furthermore, Cytological observations were studied using fluorescence microscopy and transmission electron microscopy, DNA laddering in agarose gel electrophoresis assay used to detect the mode of cell death and analysis of the cellular DNA content by flowcytometery. RESULTS: MTT proliferation assay, Cytological observations using fluorescence microscopy and transmission electron microscopy show the anti-proliferation effect and apoptogenic features of NDV on DBTRG.05MG. Furthermore, analysis of the cellular DNA content showed that there was a loss of treated cells in all cell cycle phases (G1, S and G2/M) accompanied with increasing in sub-G1 region (apoptosis peak). CONCLUSION: It could be concluded that NDV strain AF2240 is a potent antitumor agent that induce apoptosis and its cytotoxicity increasing while increasing of time and virus titer.
has issue date	2019-01-01(xsd:dateTime)
bibo:doi	10.31557/apjcp.2019.20.3.757
bibo:pmid	30909682
has license	no-cc
sha1sum (hex)	d8716057edc20cdcb232b1ce062ff2804bfd041d
schema:url	https://doi.org/10.31557/apjcp.2019.20.3.757
resource representing a document's title	Evaluation of Ultra-Microscopic Changes and Proliferation of Apoptotic Glioblastoma Multiforme Cells Induced by Velogenic Strain of Newcastle Disease Virus AF2240
has PubMed Central identifier	PMC6825790
has PubMed identifier	30909682
schema:publication	Asian Pac J Cancer Prev
resource representing a document's body	covid:d8716057edc20cdcb232b1ce062ff2804bfd041d#body_text
is schema:about of	named entity 'proliferation' named entity 'observations' named entity 'glioblastoma' named entity 'mode' named entity 'member' named entity 'induce' named entity 'titer' named entity 'anticancer agent' named entity 'cytotoxicity' named entity 'Cells' named entity 'CELLS' named entity 'STRAIN' named entity 'PROLIFERATION ASSAY' named entity 'BRAIN TUMOR CELL LINE' named entity 'INDUCED' named entity 'FEATURES' named entity 'MEMBER OF' named entity 'STRAIN' named entity 'DBTRG.05MG' named entity 'AGAROSE GEL ELECTROPHORESIS' covid:arg/d8716057edc20cdcb232b1ce062ff2804bfd041d named entity 'OBSERVATIONS' named entity 'DNA CONTENT' named entity 'EFFECT' named entity 'DNA' named entity 'TRANSMISSION ELECTRON MICROSCOPY' named entity 'TITER' named entity 'METHODS' named entity 'INDUCE' named entity 'FLUORESCENCE MICROSCOPY' named entity 'NEWCASTLE DISEASE VIRUS' named entity 'NORMAL' named entity 'GENUS AVULAVIRUS' named entity 'ALL CELL' named entity 'KILL' named entity 'AIM' named entity 'USED' named entity 'AGENT' named entity 'CELL CYCLE' named entity 'CELLULAR' named entity 'FAMILY' named entity 'CONCLUSION' named entity 'ANTITUMOR' named entity 'INVESTIGATION' named entity 'GLIOBLASTOMA MULTIFORME' named entity 'INTEREST' named entity 'CELL DEATH' named entity 'LIMITED' named entity 'ASSAY' named entity 'GLIOBLASTOMA' named entity 'LOSS OF' named entity 'EVALUATED' named entity 'INCREASING' named entity 'SUB-' named entity 'USING' named entity 'MTT' named entity 'TO DETECT' named entity 'IN-VITRO' named entity 'TREATED' named entity 'EVALUATION' named entity 'PROLIFERATION' named entity 'MICROSCOPIC' named entity 'COULD BE' named entity 'CYTOLOGICAL' named entity 'NEWCASTLE DISEASE VIRUS' named entity 'ANALYSIS' named entity 'ANTICANCER AGENT' named entity 'APOPTOSIS' named entity 'TIME' named entity 'LADDERING' named entity 'TUMOR CELLS' named entity 'MODE' named entity 'PEAK' named entity 'REGION' named entity 'VIRUS' named entity 'PARAMYXOVIRIDAE'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software