About: Nonsteroidal anti-inflammatory drug therapy for neonatal calf diarrhea complex: Effects on calf performance

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About: Nonsteroidal anti-inflammatory drug therapy for neonatal calf diarrhea complex: Effects on calf performance Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nonsteroidal anti-inflammatory drug therapy for neonatal calf diarrhea complex: Effects on calf performance
Creator	Leslie, K Millman, S Todd, C Duffield, T Mcknight, D
Source	Medline; PMC
abstract	The aim of this study was to examine the efficacy of meloxicam (MEL) as supportive therapy for calves with neonatal calf diarrhea complex. For this double-blind controlled trial, 62 Holstein male calves were purchased at birth and transported to a research facility. At the naturally occurring onset of diarrhea, defined as the first occurrence of a fecal score greater than 2 on a 4-point scale, calves were enrolled in the study. Each calf with diarrhea was randomly assigned to receive a single subcutaneous injection of MEL at a rate of 0.5 mg/kg of BW or an equal volume of placebo (PLA) solution. Milk, starter ration, and water intakes were determined daily for each calf from arrival until 56 d of age. The calves were weighed on arrival and each week thereafter. Time to weaning and weaning weight were recorded for each calf. Crude associations between treatment and each outcome variable were examined using t-tests and Pearson chi-squared tests. Subsequently, multivariable regression models were constructed to examine the impact of MEL therapy on meaningful outcome variables. The primary experimental unit in all analyses was the individual calf. In total, 56 calves presented with clinical signs of diarrhea and were enrolled in the study. Two PLA-treated calves died after being enrolled in the study, and there was no calf mortality among the MEL-treated calves. For calves that developed diarrhea after 10 d of age, MEL-treated calves were more likely to consume their entire daily milk allowance (P < 0.05) as compared with PLA-treated calves. Meloxicam-treated calves began consuming starter ration earlier (P < 0.01) and at a greater rate (P < 0.001), and consumed more water (P < 0.001) compared with PLA-treated animals. Over the study period, calves treated with MEL gained BW at a faster rate (P < 0.01) than calves treated with PLA. There was no difference in weaning weight (P > 0.05), but MEL-treated calves tended to wean earlier (P = 0.11) than PLA-treated calves. These results demonstrate that calves receiving a single injection of MEL at the onset of diarrhea had improved appetite and performance compared with PLA-treated calves. Thus, MEL is an effective supportive therapy for neonatal calf diarrhea complex.
has issue date	2010-06-01(xsd:dateTime)
bibo:doi	10.2527/jas.2009-2340
bibo:pmid	20228238
has license	cc-by-nc
sha1sum (hex)	d873e54f68ff11110fa02662eecfcbe5cb7711ed
schema:url	https://doi.org/10.2527/jas.2009-2340
resource representing a document's title	Nonsteroidal anti-inflammatory drug therapy for neonatal calf diarrhea complex: Effects on calf performance
has PubMed Central identifier	PMC7109961
has PubMed identifier	20228238
schema:publication	J Anim Sci
resource representing a document's body	covid:d873e54f68ff11110fa02662eecfcbe5cb7711ed#body_text
is schema:about of	named entity 'NONSTEROIDAL ANTI-INFLAMMATORY DRUG' named entity 'CALF' named entity 'TIME' named entity 'DIARRHEA' named entity 'SQUARED' named entity 'NO DIFFERENCE' named entity 'PLA' named entity 'EFFECTIVE' named entity 'PERIOD' named entity 'MG%' named entity 'DIED' named entity 'COMPLEX' named entity 'WEANING WEIGHT' named entity 'SINGLE' named entity 'DAILY' named entity 'CHI' named entity 'RECORDED' named entity 'RECEIVE' named entity 'PRESENTED' named entity 'POINT' named entity 'BLIND' named entity 'ONSET OF' named entity 'GREATER' named entity 'daily' named entity 'age' named entity 'improved' named entity 'diarrhea' named entity 'tests' named entity 'The' named entity 'primary' named entity 'calves' named entity 'weaning' named entity 'solution' named entity 'clinical signs' named entity 'volume' named entity 'performance' named entity 'NEONATAL CALF DIARRHEA' named entity 'PERFORMANCE' named entity 'TREATED' named entity 'BUT' named entity 'EXAMINED' named entity 'ASSIGNED' named entity 'COMPLEX' named entity 'RATE' named entity 'PEARSON' named entity 'THERAPY' named entity 'COMPARED' named entity 'LIKELY' named entity 'MALE' named entity 'AT BIRTH' named entity 'SUPPORTIVE THERAPY' named entity 'ASSOCIATIONS' named entity 'RESEARCH FACILITY' named entity 'IMPROVED' named entity '0.05' named entity 'OCCURRENCE' named entity '0.01' named entity 'DETERMINED' named entity 'CONTROLLED TRIAL' named entity 'FECAL' named entity 'ANIMALS' named entity 'SOLUTION' named entity 'PERFORMANCE' named entity 'THESE' named entity 'HOLSTEIN' named entity 'EXPERIMENTAL UNIT' named entity 'ALLOWANCE' named entity 'STUDY' named entity 'THEIR' named entity 'BEING' named entity 'TESTS' named entity 'SCALE' named entity 'TOTAL' named entity 'EFFICACY' named entity 'WATER' named entity 'SUBCUTANEOUS INJECTION' named entity 'AGE'

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