About: Single nucleotide polymorphisms in immune response genes in acute Q fever cases with differences in self-reported symptoms

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Single nucleotide polymorphisms in immune response genes in acute Q fever cases with differences in self-reported symptoms Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Single nucleotide polymorphisms in immune response genes in acute Q fever cases with differences in self-reported symptoms
Creator	Hoebe, C De Klerk, A Hackert, V Hodemaekers, H Janssen, R Schimmer, B Schneeberger, P Van Duynhoven, Y Wielders, C
Source	Medline; PMC
abstract	Genes involved in human immune response are well recognized to influence the clinical course of infection. The association of host genetics with susceptibility to and severity of clinical symptoms in acute Q fever was investigated. Single nucleotide polymorphisms (SNPs) in the IFNG (rs2430561/rs1861493), STAT1 (rs1914408), and VDR (rs2228570) genes were determined in 85 patients from the 2007 Dutch acute Q fever outbreak, and a symptom score was calculated. IFNG rs1861493 showed a significant association with the symptom score; IFNG rs2430561 showed a similar trend. These SNPs were then used to reproduce results in a 2009 outbreak population (n = 123). The median symptom score differed significantly in both populations: 2 versus 7. The significant association of IFNG rs1861493 with symptom score in the first population was not reproduced in the second population. We hypothesize that individuals in the second outbreak were exposed to a higher Coxiella burnetii dose compared to the first, which overruled the protection conferred by the A-allele of IFNG rs1861493 in the first population.
has issue date	2015-01-11(xsd:dateTime)
bibo:doi	10.1007/s10096-014-2310-9
bibo:pmid	25577174
has license	no-cc
sha1sum (hex)	d8abf967d0198fbce1283256da4c994cf9bbb89d
schema:url	https://doi.org/10.1007/s10096-014-2310-9
resource representing a document's title	Single nucleotide polymorphisms in immune response genes in acute Q fever cases with differences in self-reported symptoms
has PubMed Central identifier	PMC7088184
has PubMed identifier	25577174
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:d8abf967d0198fbce1283256da4c994cf9bbb89d#body_text
is schema:about of	named entity 'genetics' named entity 'IMMUNE RESPONSE' named entity 'SYMPTOMS' named entity 'CASES' named entity 'MEDIAN' named entity 'OUTBREAK' named entity 'GENETICS' named entity 'RESULTS' named entity 'CLINICAL SYMPTOMS' named entity 'INVESTIGATED' named entity 'INFLUENCE' named entity 'VDR' named entity 'IMMUNE RESPONSE' named entity 'IFNG' named entity 'INVOLVED' covid:arg/d8abf967d0198fbce1283256da4c994cf9bbb89d named entity 'ACUTE Q FEVER' named entity 'CLINICAL COURSE' named entity 'ACUTE Q FEVER' named entity 'SYMPTOM SCORE' named entity 'DUTCH' named entity 'SIMILAR' named entity 'STAT1' named entity 'PATIENTS' named entity 'CALCULATED' named entity 'SELF-REPORTED' named entity 'ASSOCIATION' named entity 'DETERMINED' named entity 'HOST' named entity 'SUSCEPTIBILITY' named entity 'INFECTION' named entity 'THESE' named entity 'USED' named entity 'REPRODUCE' named entity 'POPULATION' named entity 'GENES' named entity 'SINGLE NUCLEOTIDE POLYMORPHISMS' named entity 'GENES' named entity 'SIGNIFICANT' named entity 'TREND' named entity 'SNPS' named entity 'SEVERITY' named entity 'SINGLE NUCLEOTIDE POLYMORPHISMS' named entity 'HUMAN' named entity 'susceptibility' named entity 'population' named entity 'outbreak' named entity 'score' named entity 'outbreak' named entity 'IFNG' named entity 'SNPs' named entity 'STAT1' named entity 'Dutch' named entity 'immune response' named entity 'clinical symptoms' named entity 'IFNG' named entity 'Single nucleotide polymorphisms' named entity 'self-reported' named entity 'patients' named entity 'Q fever' named entity 'loci' named entity 'IFNγ' named entity 'cough' named entity 'infection' named entity 'genotypes' named entity 'buccal swab' named entity 'Netherlands' named entity 'SNPs' named entity 'Germany' named entity 'IFNG' named entity 'diarrhea' named entity 'infection' named entity 'tuberculosis'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software