About: Statin therapy did not improve the in-hospital outcome of coronavirus disease 2019 (COVID-19) infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Statin therapy did not improve the in-hospital outcome of coronavirus disease 2019 (COVID-19) infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Statin therapy did not improve the in-hospital outcome of coronavirus disease 2019 (COVID-19) infection
Creator	Hariyanto, Andree Hariyanto, Timotius Kurniawan, Kurniawan, Andree Timotius, Ivan
source	Elsevier; PMC
abstract	BACKGROUND AND AIMS: The coronavirus disease 2019 (COVID-19) number of death cases is still increasing. One of the comorbidities associated with severe outcome and mortality of COVID-19 is dyslipidemia. Statin is one of the drugs which is most commonly used for the treatment of dyslipidemic patients. This study aims to analyze the association between statin use and in-hospital outcomes of COVID-19 infection. METHODS: We systematically searched the Google Scholar database using specific keywords related to our aims until August 1st, 2020. All articles published on COVID-19 and statin were retrieved. Statistical analysis was done using Review Manager 5.4 software. RESULTS: A total of 9 studies with a total of 3,449 patients were included in our analysis. Our meta-analysis showed that statin use did not improve severity outcome [OR 1.64 (95% CI 0.51–5.23), p = 0.41, I(2) = 93%, random-effect modelling] nor mortality rate from COVID-19 infection [OR 0.78 (95% CI 0.50–1.21), p = 0.26, I(2) = 0%, fixed-effect modelling]. CONCLUSION: Statin use did not improve in-hospital outcomes of COVID-19 infections. Patients with dyslipidemia should continue taking statin drugs despite COVID-19 infection status, given its beneficial effects on cardiovascular outcomes.
has issue date	2020-08-26(xsd:dateTime)
bibo:doi	10.1016/j.dsx.2020.08.023
has license	no-cc
sha1sum (hex)	d8b4781518afeb04258b42b95163fe63c568d4bb
schema:url	https://doi.org/10.1016/j.dsx.2020.08.023
resource representing a document's title	Statin therapy did not improve the in-hospital outcome of coronavirus disease 2019 (COVID-19) infection
has PubMed Central identifier	PMC7448951
schema:publication	Diabetes Metab Syndr
resource representing a document's body	covid:d8b4781518afeb04258b42b95163fe63c568d4bb#body_text
is schema:about of	named entity 'Statin' named entity 'therapy' named entity 'COVID-19' named entity 'PATIENTS' named entity 'coronavirus disease 2019' named entity 'severe' named entity 'Background' named entity 'improve' named entity 'coronavirus disease 2019' named entity 'COVID-19' named entity 'infection' named entity 'confounding factors' named entity 'COVID-19 pandemic' named entity 'harmful effects' named entity 'pleiotropic' named entity 'TLR4' named entity 'MyD88' named entity 'cough' named entity 'statin' named entity 'statistical significance' named entity 'obesity' named entity 'anti-inflammatory' named entity 'statin' named entity 'clinical trial' named entity 'pleiotropic' named entity 'COVID' named entity 'dyslipidemia' named entity 'odds ratio' named entity 'ARDS' named entity 'COVID-19' named entity 'COVID' named entity 'lopinavir' named entity 'statin' named entity 'statin' named entity 'WHO' named entity 'heart failure' named entity 'CYP3A' named entity 'statin' named entity 'statin' named entity 'statin' named entity 'inflammasome' named entity 'statin' named entity 'Google scholar' named entity 'infection' named entity 'COVID-19' named entity 'COVID' named entity 'rosuvastatin' named entity 'CD147' named entity 'HMG-CoA reductase inhibitor' named entity 'Statin' named entity 'electronic searches' named entity 'COVID-19' named entity 'metformin' named entity 'virus' named entity 'pandemic disease' named entity 'TLR' named entity 'statin' named entity 'COVID' named entity 'host cell' named entity 'Statin' named entity 'statin' named entity 'COVID-19' named entity 'confidence intervals' named entity 'NF-κB' named entity 'statin' named entity 'fixed-effects' named entity 'infection' named entity 'disease outcome' named entity 'statin' named entity 'statin' named entity 'World Health Organization' named entity 'antiinflammatory' named entity 'statin' named entity 'infectivity' named entity 'cytochrome P450' named entity 'P-gp' named entity 'statin' named entity 'protease inhibitors' named entity 'lipid-lowering drugs'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software