About: Effect of diethylcarbamazine on testing serum samples for retroviral antibodies

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About: Effect of diethylcarbamazine on testing serum samples for retroviral antibodies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Effect of diethylcarbamazine on testing serum samples for retroviral antibodies
Creator	Kitchen, L Sandronii, S
source	Elsevier; PMC
abstract	Abstract Previous investigations have revealed that in vivo use of diethylcarbamazine (N,N-diethyl-4-methyl-1-piperazine carboxamide; DEC), the mainstay of prevention and therapy for filariases, results in increased titers of antibody to feline oncornavirus-associated cell membrane antigen (FOCMA) in feline leukemia virus (FeLV)-infected cats.In the present study, the effect of in vitro DEC on detection of serum antibodies to retroviruses was investigated. The addition of DEC (5 mg ml−1, pH 7·3–7·4) to the serum diluent resulted in detection of antibody to FOCMA by indirect membrane immunofluorescence in five of five FeLV-infected cats, whereas samples from all five cats tested negative without the addition of DEC. In vitro DEC also increased the absorbance values generated by enzyme immunoassay human immunodeficiency virus type 1 (HIV-1) antibody testing of samples from (a) persons with AIDS-related disease; (b) persons with helper T-lymphocytes < 500 mm−3 blood; and (c) persons testing positive for antibody to HIV-1 env- but not gag-related antigens as determined by radioimmunoprecipitation and sodium dodecyl sulfate polyacrylamide gel electrophoresis ( RIP-SDS PAGE ). We conclude that in vitro as well as in vivo use of DEC may alter results of antibody testing for retroviruses.
has issue date	1988-02-29(xsd:dateTime)
bibo:doi	10.1016/0888-0786(88)90032-7
has license	els-covid
sha1sum (hex)	d8cb8791d55d4b24eb9486c4f75a3fb121bb614e
schema:url	https://doi.org/10.1016/0888-0786%2888%2990032-7
resource representing a document's title	Effect of diethylcarbamazine on testing serum samples for retroviral antibodies
has PubMed Central identifier	PMC7148888
schema:publication	Serodiagnosis and Immunotherapy in Infectious Disease
resource representing a document's body	covid:d8cb8791d55d4b24eb9486c4f75a3fb121bb614e#body_text
is schema:about of	named entity 'antibodies' named entity 'EFFECT' named entity 'SERUM' named entity 'ANTIBODIES' named entity 'DIETHYLCARBAMAZINE' named entity 'TESTING' named entity 'RETROVIRAL' named entity 'SAMPLES' named entity 'diethylcarbamazine' named entity 'retroviral' named entity 'sign test' named entity 'body fluid' named entity 'serum' named entity 'GMT' named entity 'antibody' named entity 'immunocompromised patients' named entity 'HIV' named entity 'serum' named entity 'AIDS' named entity 'HIV' named entity 'sign test' named entity 'HIV' named entity 'lymphocyte' named entity 'FeLV' named entity 'FeLV' named entity 'cytotoxic T cells' named entity 'serologic' named entity 'antibody' named entity 'lymphocytes' named entity 'seronegative' named entity 'antibodies' named entity 'lymphocytes' named entity 'gene' named entity 'ETA' named entity 'antigen' named entity 'env' named entity 'FeLV' named entity 'virus' named entity 'antibody' named entity 'hemophiliacs' named entity 'diluent' named entity 'FeLV' named entity 'serum samples' named entity 'FeLV' named entity 'differential diagnosis' named entity 'infection' named entity 'HIV vaccine' named entity 'asymptomatic' named entity 'HIV' named entity 'titer' named entity 'AZT' named entity 'hemophiliacs' named entity 'serum samples' named entity 'lymphocytes' named entity 'HIV' named entity 'lymphocytes' named entity 'HIV' named entity 'diluent' named entity 'null hypothesis' named entity 'human immunodeficiency virus type 1' named entity 'monoclonal antibodies' named entity 'antigens' named entity 'serum' named entity 'antibody' named entity 'Memorial Sloan-Kettering Cancer Center' named entity 'tested positive for HIV' named entity 'antibody' named entity 'antibody' named entity 'carboxamide' named entity 'HTLV-III' named entity 'antibody' named entity 'leukocyte' named entity 'HIV' named entity 'breeding colonies' named entity 'Abbott Laboratories' named entity 'neoplasias' named entity 'serum' named entity 'AIDS' named entity 'HIV antibodies' named entity 'AIDS' named entity 'Antibody' named entity 'titer'

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