About: Investigations into the presence of nidoviruses in pythons

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Investigations into the presence of nidoviruses in pythons
Creator	Hoffmann, Bernd Beer, Martin Höper, Dirk Blahak, Silvia Jenckel, Maria Schlottau, Kore
topic	covid:d8d17ed0a635b0771ab27b88b15e868759b1dfb2#this
Source	Medline; PMC
abstract	BACKGROUND: Pneumonia and stomatitis represent severe and often fatal diseases in different captive snakes. Apart from bacterial infections, paramyxo-, adeno-, reo- and arenaviruses cause these diseases. In 2014, new viruses emerged as the cause of pneumonia in pythons. In a few publications, nidoviruses have been reported in association with pneumonia in ball pythons and a tiger python. The viruses were found using new sequencing methods from the organ tissue of dead animals. METHODS: Severe pneumonia and stomatitis resulted in a high mortality rate in a captive breeding collection of green tree pythons. Unbiased deep sequencing lead to the detection of nidoviral sequences. A developed RT-qPCR was used to confirm the metagenome results and to determine the importance of this virus. A total of 1554 different boid snakes, including animals suffering from respiratory diseases as well as healthy controls, were screened for nidoviruses. Furthermore, in addition to two full-length sequences, partial sequences were generated from different snake species. RESULTS: The assembled full-length snake nidovirus genomes share only an overall genome sequence identity of less than 66.9% to other published snake nidoviruses and new partial sequences vary between 99.89 and 79.4%. Highest viral loads were detected in lung samples. The snake nidovirus was not only present in diseased animals, but also in snakes showing no typical clinical signs. CONCLUSIONS: Our findings further highlight the possible importance of snake nidoviruses in respiratory diseases and proof multiple circulating strains with varying disease potential. Nidovirus detection in clinical healthy individuals might represent testing during the incubation period or reconvalescence. Our investigations show new aspects of nidovirus infections in pythons. Nidoviruses should be included in routine diagnostic workup of diseased reptiles.
has issue date	2020-01-17(xsd:dateTime)
bibo:doi	10.1186/s12985-020-1279-5
bibo:pmid	31952524
has license	cc-by
sha1sum (hex)	d8d17ed0a635b0771ab27b88b15e868759b1dfb2
schema:url	https://doi.org/10.1186/s12985-020-1279-5
resource representing a document's title	Investigations into the presence of nidoviruses in pythons
has PubMed Central identifier	PMC6969405
has PubMed identifier	31952524
schema:publication	Virol J
resource representing a document's body	covid:d8d17ed0a635b0771ab27b88b15e868759b1dfb2#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/d8d17ed0a635b0771ab27b88b15e868759b1dfb2
is schema:about of	named entity 'pneumonia' named entity 'stomatitis' named entity 'bacterial infections' named entity '2014' named entity 'Investigations' named entity 'CAUSE' named entity 'DIFFERENT' named entity 'ARENAVIRUSES' named entity 'TIGER' named entity 'PYTHONS' named entity 'SEQUENCING' named entity 'STOMATITIS' named entity 'APART' named entity 'BALL' named entity 'SEVERE' named entity 'REPORTED' named entity 'ANIMALS' named entity 'NEW' named entity 'PUBLICATIONS' named entity 'DISEASES' named entity 'ORGAN TISSUE' named entity 'REPRESENT' named entity 'DEAD' named entity 'FOUND' named entity 'SNAKES' named entity 'BACKGROUND' named entity 'PYTHON' named entity 'HAVE' covid:arg/d8d17ed0a635b0771ab27b88b15e868759b1dfb2 named entity 'FATAL' named entity 'INVESTIGATIONS' named entity 'VIRUSES' named entity 'ASSOCIATION' named entity 'ADENO' named entity 'PNEUMONIA' named entity 'BACTERIAL INFECTIONS' named entity 'USING' named entity 'METHODS' named entity 'PYTHONS' named entity 'PRESENCE OF' named entity 'THESE' named entity 'animals' named entity 'tiger' named entity 'python' named entity 'viruses' named entity 'python' named entity 'RNA' named entity 'RT-qPCR' named entity 'pythons' named entity 'germs' named entity 'genomes' named entity 'retrovirus' named entity 'Morelia spilota' named entity 'oral mucosal' named entity 'genome' named entity 'pneumonia' named entity 'inflammation' named entity 'tracheobronchial' named entity 'Bio-Rad' named entity 'infection' named entity 'host range' named entity 'antibiotic' named entity 'histological' named entity 'suborder' named entity 'snake' named entity 'nidoviruses' named entity 'nidovirus' named entity 'green tree pythons' named entity 'genus' named entity 'gross pathology' named entity 'feces' named entity 'RT-qPCR' named entity 'stomatitis' named entity 'virus replication'

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